Electroencephalographic sleep and urinary free cortisol in adolescent depression: a preliminary report of changes from episode to recovery

Rao, Uma; McCracken, James T.; Lutchmansingh, Preetam; Edwards, Carla; Poland, Russell E.

doi:10.1016/s0006-3223(96)00430-1

Cited by 25Stress Responses and CortisolSleep and Wakefulness ResearchTreatment of Major Depression

Electroencephalographic sleep and urinary free cortisol in adolescent depression: a preliminary report of changes from episode to recovery

Rao, Uma, McCracken, James T., Lutchmansingh, Preetam, Edwards, Carla, Poland, Russell E.·1997·Biological Psychiatry

DOI 10.1016/s0006-3223(96)00430-1

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Rao et al. (1997) reported significant reductions in basal cortisol after remission from an MDD episode, indicating HPA-axis dysregulation may be accentuated during depressive states.
“For example, while Rao et al. (1997) reported significant reductions in basal cortisol after remission from an MDD episode, indicating that HPA-Axis dysregulation may be accentuated during depressive states, there is also evidence that HPA dysregulation is already present prior to the onset of depressive symptoms (Halligan et al., 2007) or MDD (Goodyer et al., 2000b).”
From Hypothalamic–pituitary–adrenal axis dysregulation in depressed children and adolescents: A meta-analysis (2009) · cites this paper as Rao et al. (1997)

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“For example, while Rao et al. (1997) reported significant reductions in basal cortisol after remission from anMDD episode, indicating that HPA-axis dysregulation may be accentuated during depressive states, there is also evidence that HPA-dysregulation is already present prior to the onset of…”
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Author index to volume 41
(1997) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00237-0

Electroencephalographic Sleep and Hypothalamic–Pituitary–Adrenal Changes from Episode to Recovery in Depressed Adolescents
Rao, U., & Poland, R. E. (2008) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2008.034 · Cited by 46 · see citing works
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Risk markers for depression in adolescents: sleep and HPA measures. Neuropsychopharmacology
Rao, U., Hammen, C. L., Ph., D., Pol, R. E., & Ph., D. (2009)
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Risk Markers for Depression in Adolescents: Sleep and HPA Measures
Rao, U., Hammen, C. L., & Poland, R. E. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.27 · Cited by 96 · see citing works
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The relationship between longitudinal clinical course and sleep and cortisol changes in adolescent depression
Rao, U., Dahl, R. E., Ryan, N. D., Birmaher, B. B., Williamson, D. E., Giles, D. E., Rao, R., Kaufman, J., & Nelson, B. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(95)00481-5 · Cited by 123 · see citing works
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Electroencephalographic sleep profiles in treatment course and long-term outcome of major depression: association with DEX/CRH-test response
Hatzinger, M., Hemmeter, U., Brand, S., Ising, M., & Holsboer‐Trachsler, E. (2004) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2004.01.010 · Cited by 94 · see citing works

Authors: Rao, U., McCracken, J. T., Lutchmansingh, P., Edwards, C., & Poland, R. E.
Affiliations: University of California, Los Angeles (US)
Corresponding author: Rao, Uma
ORCID: Rao, Uma
McCracken, James T.
Poland, Russell E.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 1997-02
Volume: 41
Issue: 3
Pages: 369-373
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/s0006-3223(96)00430-1
OpenAlex: W2074836353
Cited by: 25
References: 33
Citations by year: 2025: 1 · 2020: 1 · 2017: 1 · 2015: 1 · 2014: 2
FWCI: 0.81
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5k11mh000722-05)
National Institute of Mental Health (MH-00722, MH-34471, MH-00534, K02MH000534)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords: adolescent depression, sleep EEG, urinary free cortisol, hypothalamic-pituitary-adrenal axis, trait versus state, clinical remission, major depressive disorder, biological vulnerability
MeSH terms: Adolescent, Depressive Disorder, Electroencephalography, Female, Humans, Hydrocortisone, Male, Psychiatric Status Rating Scales, Sleep, Sleep, REM

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Electroencephalographic sleep and urinary free cortisol in adolescent depression: a preliminary report of changes from episode to recovery

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