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Cited by 247Treatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychotherapy Techniques and Applications

The DOI matches its Crossref record; 43 of the 44 references it cites were found in a registry or an index.

Major depressive subtypes and treatment response

Fava, Maurizio, Uebelacker, Lisa A., Alpert, Jonathan E., Nierenberg, Andrew A., Pava, Joel A., Rosenbaum, Jerrold F.·1997·Biological Psychiatry
DOI 10.1016/s0006-3223(96)00440-4
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Abstract

The purpose of this study was to investigate the relationships between depressive subtypes and response to fluoxetine treatment in a large cohort of outpatients. We studied 294 outpatients with major depressive disorder who were then treated with fluoxetine 20 mg/day for 8 weeks. Treatment outcome was evaluated with the Hamilton Depression Rating Scale (HDRS)-17, the Clinical Global Impressions-Severity, and with the HDRS-8; the latter is proposed to be a relatively more specific measure of depression severity than the HDRS-17. We assessed the relationships between degree of treatment response and several depressive subtypes (melancholic, atypical, hostile, and anxious depression, double depression, and depression with comorbid personality disorders), after adjusting for baseline depression severity. We found that nonanxious depressives (patients without any comorbid anxiety disorder) improved slightly but significantly more during treatment than anxious depressives on all outcome measures. Melancholic depression was associated with slightly less improvement on the HDRS-17 only, whereas the other subtypes of depression were not associated with differences in treatment outcome.

Overview

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Crossref · 10.1016/s0006-3223(96)00440-4

Cites

43 of 43 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 1

  1. Fava, 1991, Anger attacks in depressed outpatients, Psychopharmacol Bull, 27, 275

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Metadata

Authors
Fava, M., Uebelacker, L. A., Alpert, J. E., Nierenberg, A. A., Pava, J. A., & Rosenbaum, J. F.
Affiliations
Massachusetts General Hospital (US)
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
1997-10
Volume
42
Issue
7
Pages
568-576
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/s0006-3223(96)00440-4
OpenAlex
W1972105422
Cited by
247
References
44
Citations by year
2026: 2 · 2025: 7 · 2024: 9 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 7 · 2018: 9 · 2017: 8 · 2016: 9 · 2015: 10 · 2014: 8 · 2013: 10 · 2012: 11
FWCI
3.35
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (1r01mh048483-01a1)
  • National Institute of Mental Health (R01 MH48483-01)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
Keywords
major depressive disorder, depression subtypes, fluoxetine, treatment response, endogenous depression, atypical depression, anxious depression, double depression, comorbid personality disorders, comorbid anxiety disorders, depression severity, outpatients
MeSH terms
Adolescent, Adult, Aged, Anxiety, Depressive Disorder, Female, Fluoxetine, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Antidepressive Agents, Second-Generation

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