Cited by 247Treatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychotherapy Techniques and Applications

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Major depressive subtypes and treatment response

Fava, Maurizio, Uebelacker, Lisa A., Alpert, Jonathan E., Nierenberg, Andrew A., Pava, Joel A., Rosenbaum, Jerrold F.·1997·Biological Psychiatry

DOI 10.1016/s0006-3223(96)00440-4

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Abstract

The purpose of this study was to investigate the relationships between depressive subtypes and response to fluoxetine treatment in a large cohort of outpatients. We studied 294 outpatients with major depressive disorder who were then treated with fluoxetine 20 mg/day for 8 weeks. Treatment outcome was evaluated with the Hamilton Depression Rating Scale (HDRS)-17, the Clinical Global Impressions-Severity, and with the HDRS-8; the latter is proposed to be a relatively more specific measure of depression severity than the HDRS-17. We assessed the relationships between degree of treatment response and several depressive subtypes (melancholic, atypical, hostile, and anxious depression, double depression, and depression with comorbid personality disorders), after adjusting for baseline depression severity. We found that nonanxious depressives (patients without any comorbid anxiety disorder) improved slightly but significantly more during treatment than anxious depressives on all outcome measures. Melancholic depression was associated with slightly less improvement on the HDRS-17 only, whereas the other subtypes of depression were not associated with differences in treatment outcome.

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Authors: Fava, M., Uebelacker, L. A., Alpert, J. E., Nierenberg, A. A., Pava, J. A., & Rosenbaum, J. F.
Affiliations: Massachusetts General Hospital (US)
ORCID: Uebelacker, Lisa A.
Alpert, Jonathan E.
Nierenberg, Andrew A.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 1997-10
Volume: 42
Issue: 7
Pages: 568-576
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/s0006-3223(96)00440-4
OpenAlex: W1972105422
Cited by: 247
References: 44
Citations by year: 2026: 2 · 2025: 7 · 2024: 9 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 7 · 2018: 9 · 2017: 8 · 2016: 9 · 2015: 10 · 2014: 8 · 2013: 10 · 2012: 11
FWCI: 3.35
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (1r01mh048483-01a1)
National Institute of Mental Health (R01 MH48483-01)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
Keywords: major depressive disorder, depression subtypes, fluoxetine, treatment response, endogenous depression, atypical depression, anxious depression, double depression, comorbid personality disorders, comorbid anxiety disorders, depression severity, outpatients
MeSH terms: Adolescent, Adult, Aged, Anxiety, Depressive Disorder, Female, Fluoxetine, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Antidepressive Agents, Second-Generation

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