Cited by 209Stress Responses and CortisolAdrenal Hormones and DisordersPosttraumatic Stress Disorder Research

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Hormone profiles in humans experiencing military survival training

Morgan, Charles A, Wang, Sheila, Mason, John, Southwick, Steven M, Fox, Patrick, Hazlett, Gary, Charney, Dennis S, Greenfield, Gary·2000·Biological Psychiatry

DOI 10.1016/s0006-3223(99)00307-8

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Abstract

Background Clinical models of the human response to intense, acute stress have been limited to laboratory settings or cross sectional characterizations. As a result, data about the sensitivity of the human neuroendocrine activation to realistic stressors of varying magnitudes are limited. The U.S. Army survival course offers a unique opportunity to examine, in a controlled manner, the human response to acute, realistic, military stress.Methods Salivary data were collected in 109 subjects at baseline during four stress exposure time points and at recovery. Serum data was collected at baseline and recovery in 72 subjects and at baseline and during stress exposure in a subgroup of subjects (n = 21).Results Cortisol significantly increased during the captivity experience and was greatest after subjects' exposure to interrogations. Cortisol remained significantly elevated at recovery. Testosterone was significantly reduced within 12 hours of captivity. Reductions of both total and free T4 and of total and free T3 were observed, as were increases in thyrotropin.Conclusions The stress of military survival training produced dramatic alterations in cortisol, percent free cortisol, testosterone, and thyroid indices. Different types of stressors had varying effects on the neuroendocrine indices. The degree of neuroendocrine changes observed may have significant implications for subsequent responses to stress.

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Authors: Morgan, C. A., Wang, S., Mason, J., Southwick, S. M., Fox, P., Hazlett, G., Charney, D. S., & Greenfield, G.
Affiliations: Yale University (US)
United States Department of the Army (US)
United States Army (US)
Corresponding author: Morgan, Charles A
ORCID: Wang, Sheila
Southwick, Steven M
Charney, Dennis S
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2000-05
Volume: 47
Issue: 10
Pages: 891-901
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/s0006-3223(99)00307-8
OpenAlex: W2024255098
Cited by: 206
References: 61
Citations by year: 2026: 1 · 2025: 5 · 2024: 8 · 2023: 5 · 2022: 11 · 2021: 4 · 2020: 9 · 2019: 8 · 2018: 7 · 2017: 7 · 2016: 9 · 2015: 9 · 2014: 15 · 2013: 13 · 2012: 15
FWCI: 1.49
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Keywords: acute stress, cortisol, testosterone, free cortisol, thyroid hormones, thyroid-stimulating hormone, salivary biomarkers, serum biomarkers, captivity stress, neuroendocrine response, stress recovery
MeSH terms: Adult, Humans, Hydrocortisone, Male, Military Personnel, Saliva, Stress, Physiological, Stress Disorders, Post-Traumatic, Survival, Testosterone, Thyroid Gland, Thyroid Hormones

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Hormone profiles in humans experiencing military survival training

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