Huperzine A attenuates cognitive deficits and brain injury in neonatal rats after hypoxia ischemia
Abstract
The protective effects of huperzine A, a novel acetylcholinesterase inhibitor, on hypoxic-ischemic (HI) brain injury were investigated in neonatal rats. A unilateral HI brain injury was produced by the ligation of left common carotid artery followed by 1 h hypoxia with 7.7% oxygen in 7-day-old rat pups. After 5 weeks, HI brain injury in rat pups resulted in working memory impairments shown by increased escape latency in a water maze and reduced time spent in the target quadrant. The combination of common carotid artery ligation and exposure to a hypoxic environment caused the damage in the striatum, cortex, and hippocampus in the ipsilateral hemisphere, and the neuronal loss in the CA1 region. Huperzine A was administrated daily at the dose of 0.05 or 0.1 mg/kg i.p. for 5 weeks after HI injury. The significant protection against HI injury on behavior and neuropathology was produced by huperzine A at the dose of 0.1 mg/kg. These findings suggest that huperzine A might be beneficial in the treatment of hypoxic-ischemic encephalopathy in neonates.
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Huperzine-A lessens glutamate-induced cytotoxicity by antagonizing cerebral NMDA receptors.
“Huperzine-A has been proved to lessen the glutamate-induced cytotoxicity by its antagonizing action on cerebral N-methyl-D-aspartate (NMDA) receptors”
From Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer’s Disease Therapy (2021) · cites this paper as [135]
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Kim, H. (2008) · Springer eBooks · doi:10.1007/978-3-540-79116-4_16
Neuroprotective natural products
Das, S. K., Nahar, L., Nath, R., Nath, D., Sarker, S. D., & Talukdar, A. D. (2024) · Annual reports in medicinal chemistry · doi:10.1016/bs.armc.2024.09.008
Ma, J., Miao, M., Liu, X., Tian, X., Zhang, C., Li, Y., Zhao, C., Liu, J., Xie, K., Tang, C., et al. (2026) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl54346
- Authors
- Wang, L. S., Zhou, J., Shao, X. M., & Tang, X. C.
- Affiliations
- Shanghai Medical College of Fudan University (CN)
- Chinese Academy of Sciences (CN)
- Corresponding author
- Tang, Xi Can
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2002-09
- Volume
- 949
- Issue
- 1-2
- Pages
- 162-170
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2042318240
- Cited by
- 65
- References
- 32
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 3 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 5 · 2012: 3
- FWCI
- 4.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Keywords
- huperzine A, hypoxic-ischemic brain injury, neonatal hypoxic-ischemic encephalopathy, acetylcholinesterase inhibitor, cognitive impairment, working memory, striatum, cerebral cortex, neuroprotection, carotid artery ligation, water maze
- MeSH terms
- Alkaloids, Animals, Animals, Newborn, Brain Injuries, Carotid Arteries, Cerebral Cortex, Cholinesterase Inhibitors, Cognition, Corpus Striatum, Dose-Response Relationship, Drug, Female, Hippocampus, Male, Sesquiterpenes, Water, Rats, Sprague-Dawley, Neuroprotective Agents, Maze Learning, Hypoxia-Ischemia, Brain, Rats
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