Reinnervation of denervated muscle by transplantation of fetal spinal cord to transected sciatic nerve in the rat
Abstract
When motor neurons in the spinal cord are destroyed, regeneration of motor axons and muscle reinnervation cannot be expected. We attempted reinnervation of the denervated muscle, i.e. motor unit reconstruction, using transplantation of the fetal spinal cord to the peripheral nerve. The sciatic nerve of an adult rat was resected for 20 mm, and a cavity was prepared using an autologous femoral vein at the distal stump of the nerve. The fetal spinal cord was then transplanted into the venous cavity. After 3-6 months, no voluntary muscle contraction was observed due to the absence of communication with the central nervous system. However, reinnervation of the muscles via the sciatic nerve by the transplanted spinal neurons was demonstrated electrophysiologically and histochemically. This suggested that a motor unit can be reconstructed by fetal spinal cord transplantation even if the original motor neurons in the spinal cord are not available.
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Reinnervation of the gastrocnemius and tibialis muscles via the distal stump of the sciatic nerve was observed after a few weeks, although there was no communication with the CNS.
“Reinnervation of the gastrocnemius and tibialis muscles via the distal stump of the sciatic nerve was observed after a few weeks, although there was no communication with the CNS.”
From A critical review of interfaces with the peripheral nervous system for the control of neuroprostheses and hybrid bionic systems (2005) · cites this paper as Katsuki et al., 1997
An animal model for a biohybrid approach to cure flaccid paralysis involves transplanting embryonic spinal cord cells into a container adapted to the distal nerve stump to restore skeletal muscle function.
“researchers have developed an animal model for a biohybrid approach to cure flaccid paralysis that involves embryonic spinal cord cell transplantation into a container adapted to the distal nerve stump to restore skeletal muscle function (Katsuki et al., 1997; Thomas et al., 2000; Klinge et al., 2001b)”
From A critical review of interfaces with the peripheral nervous system for the control of neuroprostheses and hybrid bionic systems (2005) · cites this paper as Katsuki et al., 1997
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Navarro, X., Krueger, T. B., Lago, N., Micera, S., Stieglitz, T., & Dario, P. (2005) · Journal of the Peripheral Nervous System · doi:10.1111/j.1085-9489.2005.10303.x · Cited by 845 · see citing works
Klinge, P. M., Vafa, M. A., Brinker, T., Brandis, A., Walter, G. F., Stieglitz, T., Samii, M., & Wewetzer, K. (2001) · Biomaterials · doi:10.1016/s0142-9612(00)00420-8 · Cited by 64 · see citing works
- Authors
- Katsuki, M., Atsuta, Y., & Hirayama, T.
- Affiliations
- Asahikawa Medical College Hospital (JP)
- ORCID
- Atsuta, Yuji
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1997-10
- Volume
- 771
- Issue
- 1
- Pages
- 31-36
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2077802662
- Cited by
- 14
- References
- 0
- FWCI
- 0.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education (07807135)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Pathology and Forensic Medicine › Spinal Cord Injury Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Keywords
- muscle reinnervation, denervated muscle, fetal spinal cord transplantation, sciatic nerve transection, motor neuron degeneration, motor axon regeneration, peripheral nerve regeneration
- MeSH terms
- Animals, Axons, Choline O-Acetyltransferase, Electric Stimulation, Femoral Vein, Motor Neurons, Muscle Denervation, Muscle, Smooth, Vascular, Nerve Regeneration, Neuromuscular Junction, Peroneal Nerve, Sciatic Nerve, Spinal Cord, Tibial Nerve, Transplantation, Autologous, Fetal Tissue Transplantation, Rats, Sprague-Dawley, Muscle, Skeletal, Muscle Fibers, Skeletal, Rats
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