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Cited by 64Neuroscience and Neural EngineeringNerve injury and regenerationPeripheral Neuropathies and Disorders

Immunohistochemical characterization of axonal sprouting and reactive tissue changes after long-term implantation of a polyimide sieve electrode to the transected adult rat sciatic nerve

Klinge, Petra Margarete, Vafa, Morad Ali, Brinker, Thomas, Brandis, Almuth, Walter, Gerhard Franz, Stieglitz, Thomas, Samii, Madjid, Wewetzer, Konstantin·2001·Biomaterials
DOI 10.1016/s0142-9612(00)00420-8
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Abstract

The development of artificial microstructures suited for interfacing of peripheral nerves is not only relevant for basic neurophysiological research but also for future prosthetic approaches. Aim of the present study was to provide a detailed analysis of axonal sprouting and reactive tissue changes after implantation of a flexible sieve electrode to the proximal stump of the adult rat sciatic nerve. We report here that massive neurite growth after implantation, steadily increasing over a period of 11 months, was observed. Parallel to this increase was the expression of myelin markers like Po, whereas non-myelin-forming Schwann cells did not change. Compared to five weeks post-implantation. where both Schwann-cell phenotypes were intermingled with each other, non-myelin-forming Schwann cells occupied a peripheral position in each microfascicle after 11 months. After an initial increase, hematogenous macrophages were down-regulated in number but maintained close contact with the implant. However, at no time were signs of its degradation observed. It is concluded that the introduced flexible polyimide electrode is suitable for contacting peripheral nerves since it permits substantial neurite growth and offers excellent long-term stability.

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  • Inflammation characterized by accumulation of macrophages around edges of sieve holes appears to peak 6 months into implantation followed by a moderate decline, possibly as holes become filled with fibroblasts and ECM.

    “Inflammation, characterized by an accumulation of macrophages around the edges of the sieve holes, appears to peak 6 months into implantation followed by a moderate decline—possibly as the holes become filled with fibroblasts and ECM (Klinge et al., 2001).”

    From Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics (2021) · cites this paper as Klinge et al., 2001

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Authors
Klinge, P. M., Vafa, M. A., Brinker, T., Brandis, A., Walter, G. F., Stieglitz, T., Samii, M., & Wewetzer, K.
Affiliations
  • Medizinische Hochschule Hannover (DE)
  • KRH Klinikum Nordstadt (DE)
  • Fraunhofer Institute for Biomedical Engineering (DE)
Corresponding author
Wewetzer, Konstantin
ORCID
Venue
Biomaterials
Publisher
Elsevier BV
Published
2001-09
Volume
22
Issue
17
Pages
2333-2343
ISSN
0142-9612 (ISSN-L)
DOI
10.1016/s0142-9612(00)00420-8
OpenAlex
W2051753303
Cited by
64
References
47
Citations by year
2026: 2 · 2022: 5 · 2021: 3 · 2020: 1 · 2019: 3 · 2017: 3 · 2016: 3 · 2015: 8 · 2014: 3 · 2013: 2
FWCI
1.35
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biomaterials (publishedVersion)
  • PubMed (publishedVersion)
  • Publikationsdatenbank der Fraunhofer-Gesellschaft (Fraunhofer-Gesellschaft) (submittedVersion)
  • Fraunhofer-Publica (Fraunhofer-Gesellschaft) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
Keywords
axonal sprouting, peripheral nerve interfaces, sciatic nerve transection, neurite outgrowth, Schwann cells, macrophages, peripheral nerve regeneration, long-term implant stability
MeSH terms
Animals, Axons, Biocompatible Materials, Electrodes, Implanted, Female, Foreign-Body Reaction, Immunohistochemistry, Male, Materials Testing, Neuromuscular Junction, Neurons, Polymers, Schwann Cells, Sciatic Nerve, Time Factors, Neurofilament Proteins, Rats, Sprague-Dawley, Rats

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