Melatonin blocks the induction of long-term potentiation in an N-methyl-d-aspartate independent manner
Abstract
Perfusion of 100 microM melatonin had no effect on low frequency synaptic transmission, but prevented the induction of tetanically induced long-term potentiation (LTP) when recorded in the dendritic region of the CA1 in rat hippocampal slices. Perfusion of 100 microM melatonin in this preparation had no effect on the multiple population spikes recorded in Mg2+-free medium, and, in grease-gap recordings from the CA1-subiculum slice, 100 microM melatonin had no effect on depolarisations evoked by N-methyl-D-aspartate (NMDA) or alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA). This suggests that melatonin has the ability to prevent the formation of LTP, and that this effect is not mediated by blockade of NMDA receptors.
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Melatonin inhibits hippocampal LTP.
“Melatonin inhibits hippocampal LTP (223,877,1171,1307)”
From About Sleep's Role in Memory (2013) · cites this paper as [223]
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- Authors
- Collins, D. R., & Davies, S. N.
- Affiliations
- University of Aberdeen (GB)
- Corresponding author
- Davies, Stephen N
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1997-08
- Volume
- 767
- Issue
- 1
- Pages
- 162-165
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1984261954
- Cited by
- 44
- References
- 0
- Citations by year
- 2022: 1 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 1 · 2015: 1 · 2014: 4 · 2013: 6 · 2012: 2
- FWCI
- 0.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- melatonin, long-term potentiation, NMDA receptor blockade, hippocampal CA1, tetanic stimulation, synaptic plasticity, glutamate receptors, subiculum
- MeSH terms
- Animals, Culture Media, Magnesium, Melatonin, Synaptic Transmission, Perfusion, Receptors, N-Methyl-D-Aspartate, N-Methylaspartate, Long-Term Potentiation, alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid, Excitatory Amino Acid Antagonists, Excitatory Postsynaptic Potentials, Rats, In Vitro Techniques
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