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Quantitative immunocytochemistry of DARPP-32-expressing neurons in the rat caudatoputamen

Ouimet, Charles C, Langley-Gullion, Kathryn C, Greengard, Paul·1998·Brain Research
DOI 10.1016/s0006-8993(98)00724-0
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Abstract

DARPP-32, a dopamine and cAMP-regulated phosphoprotein with an apparent molecular weight of 32 kD, is enriched in dopaminoceptive brain regions. Chief among these regions is the caudatoputamen which contains a large number of DARPP-32-containing medium sized spiny neurons. Since medium spiny neurons are a heterogeneous population with respect to connections and chemical neuroanatomy, it seemed of interest to determine whether DARPP-32 is present in all medium-sized neurons, or only within a specific subpopulation. The present study used immunocytochemistry and quantitative analysis to address this issue. We demonstrate that DARPP-32 is contained in almost all medium-sized neurons (96.4%) and is not detected in large neurons. Taken together with previous observations that the DARPP-32-containing medium-sized neurons project heavily to all neostriatal targets, these data demonstrate that DARPP-32 is present in virtually all neostriatal output neurons. Thus, the DARPP-32 cascade represents a final common pathway through which convergent afferent fibers using a variety of neurotransmitter agents may modulate striatal outflow.

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Research works printed but not linked: 35

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Metadata

Authors
Ouimet, C. C., Langley-Gullion, K. C., & Greengard, P.
Venue
Brain Research
Publisher
Elsevier BV
Published
1998-10
Volume
808
Issue
1
Pages
8-12
ISSN
0006-8993
DOI
10.1016/s0006-8993(98)00724-0
Cited by
165
References
1
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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