Neuronal replacement from endogenous precursors in the adult brain after stroke
Open accessAbstract
In the adult brain, new neurons are continuously generated in the subventricular zone and dentate gyrus, but it is unknown whether these neurons can replace those lost following damage or disease. Here we show that stroke, caused by transient middle cerebral artery occlusion in adult rats, leads to a marked increase of cell proliferation in the subventricular zone. Stroke-generated new neurons, as well as neuroblasts probably already formed before the insult, migrate into the severely damaged area of the striatum, where they express markers of developing and mature, striatal medium-sized spiny neurons. Thus, stroke induces differentiation of new neurons into the phenotype of most of the neurons destroyed by the ischemic lesion. Here we show that the adult brain has the capacity for self-repair after insults causing extensive neuronal death. If the new neurons are functional and their formation can be stimulated, a novel therapeutic strategy might be developed for stroke in humans.
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Neurogenesis is sustained in the subventricular zone and dentate gyrus subgranular layer, which host neural precursor cells even in adulthood.
“Neurogenesis is sustained in the germinal niches in the subventricular zone of the lateral ventricle and the subgranular layer of the dentate gyrus, which host neural precursor cells even during adulthood.34,35”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [35]
The survival rate of adult neural precursor cells in brain parenchyma is poor, and only a small percentage differentiate into neurons.
“The survival rate of adult neural precursor cells in the brain parenchyma is poor and only a small percentage of the cells differentiate into neurons.35,39–42”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [35]
Neurogenesis is stimulated in response to stroke and is substantially amplified by therapeutic interventions that promote functional recovery.
“Neurogenesis is stimulated in response to stroke and is substantially amplified by therapeutic interventions that promote functional recovery.33–36”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [35]
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- Authors
- Arvidsson, A., Collin, T., Kirik, D., Kokaia, Z., & Lindvall, O.
- Affiliations
- Skåne University Hospital (SE)
- Corresponding author
- Arvidsson, Andreas
- Venue
- Nature Medicine
- Published
- 2002-08-05
- Volume
- 8
- Issue
- 9
- Pages
- 963-970
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2168272960
- Semantic Scholar
- 3490e2e4f5d5f4e5d8f734f58fb6a074c4414475
- Cited by
- 2,799
- References
- 36
- Citations by year
- 2026: 38 · 2025: 55 · 2024: 54 · 2023: 71 · 2022: 59 · 2021: 82 · 2020: 106 · 2019: 101 · 2018: 113 · 2017: 121 · 2016: 138 · 2015: 125 · 2014: 150 · 2013: 187 · 2012: 182
- FWCI
- 21.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion, other-oa)
- Funders
- Vetenskapsrådet
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- stroke, adult neurogenesis, subventricular zone, dentate gyrus, neuronal replacement, cell proliferation, neuroblast migration, striatum, medium spiny neurons, neuronal differentiation, ischemic brain injury, self-healing, middle cerebral artery occlusion
- MeSH terms
- Pre-B-Cell Leukemia Transcription Factor 1, Doublecortin Domain Proteins, Animals, Brain, Cell Division, Cell Movement, DNA-Binding Proteins, Male, Microtubule-Associated Proteins, Neurons, Neuropeptides, Proto-Oncogene Proteins, Stem Cells, Biomarkers, Rats, Wistar, Homeodomain Proteins, Stroke, Lateral Ventricles, Rats
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