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Cited by 103Circadian rhythm and melatoninNeurotransmitter Receptor Influence on BehaviorReceptor Mechanisms and Signaling

Comparison of the effects of aging on 5-HT7 and 5-HT1A receptors in discrete regions of the circadian timing system in hamsters

Duncan, Marilyn J, Short, Joshua, Wheeler, Deborah L·1999·Brain Research
DOI 10.1016/s0006-8993(99)01311-6
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Abstract

The circadian timekeeping system exhibits many functional changes with aging, including a loss of sensitivity to time cues such as systemic injections of the serotonergic agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). In order to elucidate the neurochemical mechanisms responsible for this age-related loss of sensitivity of the circadian pacemaker to serotonin agonists, the present study used quantitative autoradiography to determine whether aging decreases serotonin receptor populations in male Syrian hamsters. Four neuroanatomical regions that regulate circadian timekeeping were studied (the suprachiasmatic nuclei [SCN], the lateral geniculate nuclei [LGN], and the median raphe nucleus [MRN] and dorsal raphe nucleus [DRN]). The specific binding of [3H]8-OH-DPAT to serotonin7 (5-HT7) and serotonin1A (5-HT1A) receptors was investigated by competitive inhibition with ritanserin and pindolol, respectively. The results showed that the SCN, IGL, MRN, and DRN of the male Syrian hamster exhibited specific binding of [3H]8-OH-DPAT to both the 5-HT7 and 5-HT1A receptors, and that the latter receptor subtype is more abundant in all of these regions. At 17-19 months of age, a 50% decrease in 5-HT7 receptors was found in the DRN but not in any other regions. No significant age-related changes in 5-HT1A receptors were observed in any regions examined. The finding that a marked decrease in 5-HT7 receptors occurs in the DRN at the age previously characterized by loss of sensitivity to 8-OH-DPAT suggests that this region and this receptor subtype play important roles in 8-OH-DPAT induction of circadian phase shifts in vivo and that they constitute an important locus of aging in the circadian timing system.

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  • Aging selectively decreases 5-HT7 receptors in the hamster dorsal raphe nucleus, strongly attenuating circadian phase shifts induced by microinjection of serotonergic agonists in this region.

    “Aging selectively decreases 5- HT7 receptors in the hamster DRN, strongly attenuating circadian phase shifts induced by microinjection of serotonergic agonists in this region (Duncan et al., 1999; Duncan et al., 2004).”

    From Biological rhythms, higher brain function, and behavior: Gaps, opportunities, and challenges (2009) · cites this paper as Duncan et al., 1999

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Authors
Duncan, M. J., Short, J., & Wheeler, D. L.
Affiliations
University of Kentucky (US)
Corresponding author
Duncan, Marilyn J
ORCID
Duncan, Marilyn J
Venue
Brain Research
Publisher
Elsevier BV
Published
1999-05
Volume
829
Issue
1-2
Pages
39-45
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/s0006-8993(99)01311-6
OpenAlex
W2045502949
Cited by
103
References
33
Citations by year
2025: 1 · 2024: 2 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 5 · 2013: 4 · 2012: 3
FWCI
2.52
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute on Aging (R01AG013418, AG 13418)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords
aging, circadian system, 5-HT7 receptor, 5-HT1A receptor, serotonin receptors, suprachiasmatic nucleus, lateral geniculate nucleus, median raphe nucleus, dorsal raphe nucleus, 8-OH-DPAT, circadian phase shift, golden hamster
MeSH terms
Aging, Animals, Brain Mapping, Circadian Rhythm, Geniculate Bodies, Cricetinae, Male, Mesocricetus, Raphe Nuclei, Receptors, Serotonin, Suprachiasmatic Nucleus, Serotonin Receptor Agonists, 8-Hydroxy-2-(di-n-propylamino)tetralin

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