LP-BM5 infection impairs spatial working memory in C57BL/6 mice in the Morris water maze.
Abstract
Previous studies show that the LP-BM5 murine leukemia virus causes an acquired immunodeficiency syndrome in C57BL/6 mice (MAIDS) and impairs learning and memory without gross motor impairment. To assess spatial working memory impairment after LP-BM5 infection and the time course of this impairment, we tested mice in a modified working-memory version of the Morris water maze. Twenty mice were inoculated with LP-BM5; controls received medium (Minimum Essential Medium). In the test procedure, animals had two 1-min training sessions to learn the position of a randomly placed hidden platform. Thirty seconds after the second training session, animals were placed in the maze without the platform, and time and pathlength spent in each quadrant of the maze were measured. For 9 weeks after LP-BM5 infection, both groups showed preference for the target quadrant compared to the opposite quadrant. At 10 and 11 weeks after infection, the LP-BM5 virus infected mice lost this target quadrant preference. We conclude that LP-BM5 infection impaired spatial working memory in a modified working-memory version of the Morris water maze test in C57BL/6 mice at 10 and 11 weeks after virus infection.
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Animal studies demonstrated that systemic immune activation by viral, bacterial, or parasitic infections results in impaired memory functioning.
“Studies in experimental animals demonstrated that systemic immune activation by viral, bacterial, or parasitic infections result in impaired memory functioning [18], [19], [20], [21], [22], [23].”
From Dose-dependent effects of endotoxin on neurobehavioral functions in humans (2011) · cites this paper as [20]
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- Authors
- Lee, B., English, J. A., & Paul, I. A.
- Affiliations
- University of Mississippi Medical Center (US)
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2000-02
- Volume
- 856
- Issue
- 1-2
- Pages
- 129-134
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2165717405
- Cited by
- 15
- References
- 37
- Citations by year
- 2016: 1 · 2012: 1
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r29mh053228-02)
- National Institute of Mental Health (MH-53228)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Keywords
- LP-BM5 murine leukemia virus, AIDS, maids, spatial working memory, memory impairment, C57BL/6 mice, Morris water maze, viral infection, immunodeficiency
- MeSH terms
- Animals, Male, Memory, Mice, Inbred C57BL, Leukemia Virus, Murine, Organ Size, Space Perception, Spleen, Murine Acquired Immunodeficiency Syndrome, Maze Learning, Mice
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