Cited by 484Seaweed-derived Bioactive CompoundsPolysaccharides Composition and ApplicationsPolysaccharides and Plant Cell Walls

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Fucoidans from the brown seaweed Adenocystis utricularis: extraction methods, antiviral activity and structural studies

Ponce, Nora M.A., Pujol, Carlos A., Damonte, Elsa B., Flores, Marı&#x;a L., Stortz, Carlos A.·2003·Carbohydrate Research

DOI 10.1016/s0008-6215(02)00403-2

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Abstract

The brown seaweed Adenocystis utricularis (family Adenocystaceae, order Ectocarpales sensu lato) was extracted in parallel with three solvents usually utilized for obtaining fucoidans: distilled water, 2% calcium chloride solution and diluted hydrochloric acid (pH 2) solution. In each case, the extraction was effected at room temperature and then at 70 degrees C. The extraction yields and characteristics of the products were similar in the three cases, with only minor differences. The analytical features of the products indicate that two different types of fucoidans are present in this seaweed. One of them, mostly extracted at room temperature, is composed mainly of L-fucose, D-galactose and ester sulfate (the 'galactofucan'). The other product (the 'uronofucoidan') is the major component of the extracts obtained at 70 degrees C. It is composed mainly of fucose, accompanied by other monosaccharides (mostly Man, but also Glc, Xyl, Rha and Gal), significant amounts of uronic acids and low proportions of sulfate ester. Fractionation with the cationic detergent cetrimide has allowed achieving a better separation of the galactofucan and uronofucoidan components. The galactofucans show a high inhibitory activity against herpes simplex virus 1 and 2, with no cytotoxicity, whereas the uronofucoidans carry no antiviral activity. Structural studies on the galactofucan fractions were carried out by methylation analysis, desulfation and NMR spectroscopy. The fucan constituent is mainly composed of 3-linked alpha-L-fucopyranosyl backbone, mostly sulfated at C-4, and branched at C-2 with non-sulfated fucofuranosyl and fucopyranosyl units, and 2-sulfated fucopyranosyl units. The galactan moiety is more heterogeneous, with predominant D-galactopyranose units linked on C-3 and C-6, and sulfation mostly on C-4, even in terminal non-reducing units. It may be inferred that at least some of these galactose units carry the alpha-configuration.

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Authors: Ponce, N. M. A., Pujol, C. A., Damonte, E. B., Flores, M. L., & Stortz, C. A.
Affiliations: Universidad de Buenos Aires (AR)
Corresponding author: Stortz, Carlos A.
ORCID: Ponce, Nora M.A.
Damonte, Elsa B.
Stortz, Carlos A.
Venue: Carbohydrate Research
Publisher: Elsevier BV
Published: 2003-01
Volume: 338
Issue: 2
Pages: 153-165
ISSN: 0008-6215 (ISSN-L)
DOI: 10.1016/s0008-6215(02)00403-2
OpenAlex: W1981755056
Cited by: 484
References: 56
Citations by year: 2026: 5 · 2025: 21 · 2024: 20 · 2023: 14 · 2022: 40 · 2021: 40 · 2020: 32 · 2019: 23 · 2018: 24 · 2017: 25 · 2016: 18 · 2015: 24 · 2014: 22 · 2013: 23 · 2012: 21
FWCI: 11.76
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Carbohydrate Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
Life Sciences › Agricultural and Biological Sciences › Plant Science › Polysaccharides and Plant Cell Walls
Keywords: fucoidan, brown algae, antiviral activity, herpes simplex virus type 1, herpes simplex virus type 2, sulfate esters, uronic acid, extraction methods, sulfated polysaccharides
MeSH terms: Animals, Antiviral Agents, Cell Survival, Chlorocebus aethiops, Chemical Fractionation, Polysaccharides, Seaweed, Vero Cells, Molecular Structure, Herpesvirus 2, Human, Herpesvirus 1, Human, Inhibitory Concentration 50

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Fucoidans from the brown seaweed Adenocystis utricularis: extraction methods, antiviral activity and structural studies

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