Fucoidans from the brown seaweed Adenocystis utricularis: extraction methods, antiviral activity and structural studies

Ponce, Nora M.A.; Pujol, Carlos A.; Damonte, Elsa B.; Flores, Marı&#x;a L.; Stortz, Carlos A.

doi:10.1016/s0008-6215(02)00403-2

Cited by 484Seaweed-derived Bioactive CompoundsPolysaccharides Composition and ApplicationsPolysaccharides and Plant Cell Walls

Fucoidans from the brown seaweed Adenocystis utricularis: extraction methods, antiviral activity and structural studies

Ponce, Nora M.A., Pujol, Carlos A., Damonte, Elsa B., Flores, Marı&#x;a L., Stortz, Carlos A.·2003·Carbohydrate Research

DOI 10.1016/s0008-6215(02)00403-2

Open this paper in CoChat — free account

Abstract

The brown seaweed Adenocystis utricularis (family Adenocystaceae, order Ectocarpales sensu lato) was extracted in parallel with three solvents usually utilized for obtaining fucoidans: distilled water, 2% calcium chloride solution and diluted hydrochloric acid (pH 2) solution. In each case, the extraction was effected at room temperature and then at 70 degrees C. The extraction yields and characteristics of the products were similar in the three cases, with only minor differences. The analytical features of the products indicate that two different types of fucoidans are present in this seaweed. One of them, mostly extracted at room temperature, is composed mainly of L-fucose, D-galactose and ester sulfate (the 'galactofucan'). The other product (the 'uronofucoidan') is the major component of the extracts obtained at 70 degrees C. It is composed mainly of fucose, accompanied by other monosaccharides (mostly Man, but also Glc, Xyl, Rha and Gal), significant amounts of uronic acids and low proportions of sulfate ester. Fractionation with the cationic detergent cetrimide has allowed achieving a better separation of the galactofucan and uronofucoidan components. The galactofucans show a high inhibitory activity against herpes simplex virus 1 and 2, with no cytotoxicity, whereas the uronofucoidans carry no antiviral activity. Structural studies on the galactofucan fractions were carried out by methylation analysis, desulfation and NMR spectroscopy. The fucan constituent is mainly composed of 3-linked alpha-L-fucopyranosyl backbone, mostly sulfated at C-4, and branched at C-2 with non-sulfated fucofuranosyl and fucopyranosyl units, and 2-sulfated fucopyranosyl units. The galactan moiety is more heterogeneous, with predominant D-galactopyranose units linked on C-3 and C-6, and sulfation mostly on C-4, even in terminal non-reducing units. It may be inferred that at least some of these galactose units carry the alpha-configuration.

Integrity signals

Registry

Crossref · 10.1016/s0008-6215(02)00403-2

Cites

56 of 56 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Longer extraction time decreases fucose and sulfate contents, resulting in low-quality fucoidan.
“A longer extraction time decreases the fucose and sulfate contents, resulting in low-quality fucoidan [23,37].”
From A Review on Fucoidan Structure, Extraction Techniques, and Its Role as an Immunomodulatory Agent (2022) · cites this paper as [37]
In Adenocystis utricularis FCSPs, the galactan moiety present is predominantly a backbone of (1→3) and (1→6) d-galactopyranose units with sulfation mostly on C-4.
“the galactan moiety, which was also present, was predominantly found to be a backbone structure of (1→3) and (1→6) d-galactopyranose units with sulfation mostly on C-4 [15].”
From Important Determinants for Fucoidan Bioactivity: A Critical Review of Structure-Function Relations and Extraction Methods for Fucose-Containing Sulfated Polysaccharides from Brown Seaweeds (2011) · cites this paper as [15]
Other algal fucoidans with the same α(1→3)-backbone of fucose residues have been found in Analipus japonicas, Adenocystis utricularis and Cladosiphon okamuranus, but FCSPs from these brown algae also appear to contain monosaccharides other than fucose.
“Other algal fucoidans whose structures contain the same α(1→3)-backbone of fucose residues have been found in Analipus japonicas (Ectocarpales), Adenocystis utricularis (Ectocarpales) and Cladosiphon okamuranus (Chordariales) [14,15,39], but the FCSPs from these brown algae also appear to contain other monosaccharides than fucose (Table 2).”
From Important Determinants for Fucoidan Bioactivity: A Critical Review of Structure-Function Relations and Extraction Methods for Fucose-Containing Sulfated Polysaccharides from Brown Seaweeds (2011) · cites this paper as [15]
Adenocystis utricularis FCSPs contain the same α-(1→3)-fucopyranose backbone as Chorda filum and Laminaria saccharina FCSPs, with fucopyranosyl units mostly sulfated at C-4 and branched at C-2 with non-sulfated fucopyranosyl units.
“Methylation analysis, desulfation and NMR spectroscopy of the FCSPs fractions from Adenocystis utricularis (Ectocarpales) showed that these FCSPs contained the same α-(1→3)-fucopyranose backbone as that found in Chorda filum and Laminaria saccharina FCSPs, and that the fucopyranosyl units were mostly sulfated at C-4, and branched at C-2 with non-sulfated fucopyranosyl units;”
From Important Determinants for Fucoidan Bioactivity: A Critical Review of Structure-Function Relations and Extraction Methods for Fucose-Containing Sulfated Polysaccharides from Brown Seaweeds (2011) · cites this paper as [15]
Longer extraction time led to poorer fucose content, whereas glucuronic acid increased while sulfate decreased with time; sulfate content was highest when glucuronic acid was lowest.
“Ponce et al. (2003) 17 thus reported that longer extraction time led to poorer fucose content, whereas glucuronic acid increased while sulfate decreased with time, i.e., the sulfate content was highest when glucuronic acid was lowest.17”
From Fucoidans from brown seaweeds: an update on structures, extraction techniques and use of enzymes as tools for structural elucidation (2013) · cites this paper as [17]

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works
Colorimetric Method for Determination of Sugars and Related Substances
DuBois, M., Gilles, K. A., Hamilton, J. K., Rebers, P. A., & Smith, F. (1956) · Analytical Chemistry · doi:10.1021/ac60111a017 · Cited by 52,269 · see citing works
Rapid colorimetric assay for cell growth and survival
Denizot, F., & Lang, R. (1986) · Journal of Immunological Methods · doi:10.1016/0022-1759(86)90368-6 · Cited by 4,907 · see citing works
A simple and rapid method for the permethylation of carbohydrates
Ciucanu, I., & Kerek, F. (1984) · Carbohydrate Research · doi:10.1016/0008-6215(84)85242-8 · Cited by 3,581 · see citing works
A note on the determination of the ester sulphate content of sulphated polysaccharides
Dodgson, K. S., & Price, R. (1962) · Biochemical Journal · doi:10.1042/bj0840106 · Cited by 1,645 · see citing works
A SUBMICRODETERMINATION OF GLUCOSE
Park, J. T., & Johnson, M. J. (1949) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)56635-7 · Cited by 1,574 · see citing works
Measurement of uronic acids without interference from neutral sugars
Filisetti-Cozzi, T. M. C. C., & Carpita, N. C. (1991) · Analytical Biochemistry · doi:10.1016/0003-2697(91)90372-z · Cited by 1,446 · see citing works
Stoichiometric depolymerization of polyuronides and glycosaminoglycuronans to monosaccharides following reduction of their carbodiimide-activated carboxyl group
Taylor, R., & Conrad, H. E. (1972) · Biochemistry · doi:10.1021/bi00758a009 · Cited by 889 · see citing works
Chemistry and enzymology of marine algal polysaccharides
Percival, E. E., & McDowell, R. H. (1967) · Cited by 686 · see citing works
Sulfated polysaccharides are potent and selective inhibitors of various enveloped viruses, including herpes simplex virus, cytomegalovirus, vesicular stomatitis virus, and human immunodeficiency virus
Baba, M., Snoeck, R., Pauwels, R., & Clercq, E. D. (1988) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.32.11.1742 · Cited by 545 · see citing works
A revised structure for fucoidan may explain some of its biological activities.
Patankar, M. S., Oehninger, S., Barnett, T., Williams, R. L., & Clark, G. F. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80609-7 · Cited by 531 · see citing works
Algal Polysaccharides
PAINTER, T. J. (1983) · The Polysaccharides · doi:10.1016/b978-0-12-065602-8.50009-1 · Cited by 506 · see citing works
Structure and Anticoagulant Activity of Sulfated Fucans
Pereira, M. S., Mulloy, B., & Mourão, P. A. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.7656 · Cited by 377 · see citing works
Further data on the structure of brown seaweed fucans: relationships with anticoagulant activity
Chevolot, L., Foucault, A., Chaubet, F., Kervarec, N., Sinquin, C., Fisher, A.-M., & Boisson-Vidal, C. (1999) · Carbohydrate Research · doi:10.1016/s0008-6215(99)00127-5 · Cited by 330 · see citing works
A study of fucoidan from the brown seaweed Chorda filum
Chizhov, A. O., Dell, A., Morris, H. R., Haslam, S. M., McDowell, R. A., Shashkov, A. S., Nifant’ev, N. E., Khatuntseva, E. A., & Usov, A. I. (1999) · Carbohydrate Research · doi:10.1016/s0008-6215(99)00148-2 · Cited by 326 · see citing works
Structural studies on fucoidans from the brown seaweed Sargassum stenophyllum
Duarte, M. E. R., Cardoso, M. A., Noseda, M. D., & Cerezo, A. S. (2001) · Carbohydrate Research · doi:10.1016/s0008-6215(01)00149-5 · Cited by 319 · see citing works
A disaccharide repeat unit is the major structure in fucoidans from two species of brown algae
Chevolot, L., Mulloy, B., Ratiskol, J., Foucault, A. P., & Colliec‐Jouault, S. (2001) · Carbohydrate Research · doi:10.1016/s0008-6215(00)00314-1 · Cited by 304 · see citing works
Polysaccharides of Algae. 48. Polysaccharide Composition of Several Calcareous Red Algae: Isolation of Alginate from Corallina pilulifera P. et R. (Rhodophyta, Corallinaceae)
Usov, A. I., Bilan, M. I., & Клочкова, Н. Г. (1995) · Botanica Marina · doi:10.1515/botm.1995.38.1-6.43 · Cited by 215 · see citing works
A new procedure for the separation of water-soluble polysaccharides from brown seaweeds
Zvyagintseva, T. N., Shevchenko, N. M., Popivnich, I. B., Isakov, V. V., Scobun, A. S., Sundukova, E. V., & Elyakova, L. A. (1999) · Carbohydrate Research · doi:10.1016/s0008-6215(99)00206-2 · Cited by 198 · see citing works
Antitumor Active Fucoidan from the Brown Seaweed,Umitoranoo(Sargassum thunbergii)
Zhuang, C., Itoh, H., Mizuno, T., & Ito, H. (1995) · Bioscience, Biotechnology, and Biochemistry · doi:10.1271/bbb.59.563 · Cited by 184 · see citing works
Sulfated fucans from echinoderms have a regular tetrasaccharide repeating unit defined by specific patterns of sulfation at the 0-2 and 0-4 positions.
Mulloy, B., Ribeiro, A.-C., Alves, A.-P., Vieira, R. P., & Mourão, P. A. S. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31763-5 · Cited by 175 · see citing works
Structural study of fucoidan from Cladosiphon okamuranus tokida
Nagaoka, M., Shibata, H., Kimura-Takagi, I., Hashimoto, S., Kimura, K., Makino, T., Aiyama, R., Ueyama, S., & Yokokura, T. (1999) · Glycoconjugate Journal · doi:10.1023/a:1006945618657 · Cited by 173 · see citing works
Anticoagulant low molecular weight fucans produced by radical process and ion exchange chromatography of high molecular weight fucans extracted from the brown seaweed Ascophyllum nodosum
Nardella, A., Chaubet, F., Boisson-Vidal, C., Blondin, C., Durand, P., & Jozefonvicz, J. (1996) · Carbohydrate Research · doi:10.1016/0008-6215(96)00110-3 · Cited by 166 · see citing works
Isolation and partial characterization of a noval amino sugar-containing fucan sulfate from commercial Fucus vesiculosus fucoidan
Nishino, T., Nishioka, C., Ura, H., & Nagumo, T. (1994) · Carbohydrate Research · doi:10.1016/s0008-6215(00)90980-7 · Cited by 157 · see citing works
Quantitation of glycosaminoglycan hexosamine using 3-methyl-2-benzothiazolone hydrazone hydrochloride
Smith, R. L., & Gilkerson, E. (1979) · Analytical Biochemistry · doi:10.1016/0003-2697(79)90170-2 · Cited by 156 · see citing works
A fucoidan fraction from Ascophyllum nodosum
Marais, M. F., & Joseleau, J. P. (2001) · Carbohydrate Research · doi:10.1016/s0008-6215(01)00257-9 · Cited by 155 · see citing works
A New Procedure for the Isolation of Anti-HIV Compounds (Polysaccharides and Polyphenols) from the Marine Alga Fucus vesiculosus
Béress, A., Wassermann, O., Bruhn, T., Béress, L., Kraiselburd, E. N., Gonazalez, L. V., de Motta, G. E., & Chavez, P. I. (1993) · Journal of Natural Products · doi:10.1021/np50094a005 · Cited by 144 · see citing works
Antiviral properties of fucoidan fractions from Leathesia difformis
Feldman, S. C., Reynaldi, S., Stortz, C. A., Cerezo, A. S., & Damonte, E. B. (1999) · Phytomedicine · doi:10.1016/s0944-7113(99)80055-5 · Cited by 127 · see citing works
Self-citation
Anticoagulant and antithrombin activities of oversulfated fucans
Nishino, T., & Nagumo, T. (1992) · Carbohydrate Research · doi:10.1016/s0008-6215(00)90581-0 · Cited by 122 · see citing works
A sulfated α-l-fucan from sea cucumber
Ribeiro, A.-C., Vieira, R. P., Mourão, P. A. S., & Mulloy, B. (1994) · Carbohydrate Research · doi:10.1016/s0008-6215(00)90981-9 · Cited by 122 · see citing works
Structural characterization of a new anticoagulant fucan sulfate from the brown seaweed Ecklonia kurome
Nishino, T., Nagumo, T., Kiyohara, H., & Yamada, H. (1991) · Carbohydrate Research · doi:10.1016/0008-6215(91)84147-7 · Cited by 116 · see citing works
Venous Antithrombotic and Anticoagulant Activities of a Fucoïdan Fraction
Mauray, S., Sternberg, C., Theveniaux, J., Millet, J., Sinquin, C., Tapon‐Bretaudière, J., & Fischer, A. (1995) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1649927 · Cited by 107 · see citing works
ALICIA HOFFMANN and BERNABÉ SANTELICES, with illustrations by Clara Yáñez. Flora Marina de Chile Central (Marine Flora of Central Chile) Ediciones Universidad Catolica de Chile, Santiago, Chile. 434 pp., 114 figs. US$41, +$15 postage (surface), $36 (air).
Abbott, I. A. (1998) · European Journal of Phycology · doi:10.1017/s0967026298221688 · Cited by 101 · see citing works
Carbohydrates of the brown seaweeds himanthalia lorea, bifurcaria bifurcata, and Padina pavonia
Mian, A. J., & Percival, E. (1973) · Carbohydrate Research · doi:10.1016/s0008-6215(00)85030-2 · Cited by 99 · see citing works
Properties of Highly Purified Fucan
Bernardi, G., & Springer, G. F. (1962) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)81363-1 · Cited by 94 · see citing works
Separation and quantitation of enantiomeric galactoses and their mono-O-methylethers as their diastereomeric acetylated 1-deoxy-1-(2-hydroxypropylamino) alditols
Cases, M. R., Cerezo, A. S., & Stortz, C. A. (1995) · Carbohydrate Research · doi:10.1016/0008-6215(94)00370-u · Cited by 88 · see citing works
Self-citation
Degradation of algal (Ascophyllum nodosum) fucoidan by an enzymatic activity contained in digestive glands of the marine mollusc Pecten maximus
Daniel, R., Berteau, O., Jozefonvicz, J., & Goasdoué, N. (1999) · Carbohydrate Research · doi:10.1016/s0008-6215(99)00223-2 · Cited by 84 · see citing works
The sulfate-content dependence of the anticoagulant activity of a fucan sulfate from the brown seaweed Ecklonia kurome
Nishino, T., & Nagumo, T. (1991) · Carbohydrate Research · doi:10.1016/s0008-6215(00)90542-1 · Cited by 69 · see citing works
Hydrolysis of plant cell walls with trifluoroacetic acid
Morrison, I. M. (1988) · Phytochemistry · doi:10.1016/0031-9422(88)80281-4 · Cited by 69 · see citing works
Glucuronoxylofucan, a cell-wall component of ascophyllum nodosum. Part I
Percival, E. E. (1968) · Carbohydrate Research · doi:10.1016/s0008-6215(00)81200-8 · Cited by 65 · see citing works
Fucoidin inhibits the zona pellucida-induced acrosome reaction in human spermatozoa
Mahony, M. C., Oehninger, S., Clark, G. F., Acosta, A. A., & Hodgen, G. D. (1991) · Contraception · doi:10.1016/0010-7824(91)90085-t · Cited by 63 · see citing works
Sulfated polysaccharides from the red seaweed Georgiella confluens
Kolender, A. A., & Matulewicz, M. C. (2002) · Carbohydrate Research · doi:10.1016/s0008-6215(01)00283-x · Cited by 52 · see citing works
An anticoagulant fucoidan from the brown seaweed Ecklonia kurome
Nishino, T., Kiyohara, H., Yamada, H., & Nagumo, T. (1991) · Phytochemistry · doi:10.1016/0031-9422(91)83722-w · Cited by 49 · see citing works
Total characterization of polysaccharides by gas-liquid chromatography
Turner, S. H., & Cherniak, R. (1981) · Carbohydrate Research · doi:10.1016/s0008-6215(00)85305-7 · Cited by 40 · see citing works
Molecular and morphological investigations of three brown algal genera with stellate plastids: evidence for Scytothamnales ord. nov. (Phaeophyceae)
Peters, A. F., & Clayton, M. N. (1998) · Phycologia · doi:10.2216/i0031-8884-37-2-106.1 · Cited by 38 · see citing works
Structure of the ‘corallinans’ — sulfated xylogalactans from Corallina officinalis
Cases, M. R., Stortz, C. A., & Cerezo, A. S. (1994) · International Journal of Biological Macromolecules · doi:10.1016/0141-8130(94)90021-3 · Cited by 36 · see citing works
Self-citation
Dextrin Sulphate and Fucoidan are Potent Inhibitors of HIV Infection in vitro
McClure, M. O., Whitby, D., Patience, C., Gooderham, N. J., Bradshaw, A. E., CHEINGSONG-POPOV, R., Weber, J. N., Davies, D. S., Cook, G. M. W., Keynes, R. J., et al. (1991) · Antiviral chemistry & chemotherapy · doi:10.1177/095632029100200304 · Cited by 34 · see citing works
Isolation and partial characterization of a novel β-d-galactan sulfate from the brown seaweed Laminaria angustata var. longissima
Nishino, T., Takabe, Y., & Nagumo, T. (1994) · Carbohydrate Polymers · doi:10.1016/0144-8617(94)90099-x · Cited by 31 · see citing works
The system of agaroids and carrageenans from the soluble fraction of the tetrasporic stage of the red seaweed Iridaea undulosa
Stortz, C. A., Cases, M. R., & Cerezo, A. S. (1997) · Carbohydrate Polymers · doi:10.1016/s0144-8617(97)00097-0 · Cited by 30 · see citing works
Self-citation
Adenocystaceae fam. nov. (Phaeophyceae) based on morphological and molecular evidence
ROUSSEAU, F., de Reviers, B., Leclerc, M.-C., Asensi, A. O., & Delépine, R. (2000) · European Journal of Phycology · doi:10.1080/09670260010001735601 · Cited by 24 · see citing works
Fucoidin binding activity and its localization on human spermatozoa
Mahony, M. C., Clark, G. F., Oehninger, S., Acosta, A. A., & Hodgen, G. D. (1993) · Contraception · doi:10.1016/0010-7824(93)90146-x · Cited by 22 · see citing works
Structural features of a novel glucuronogalactofucan from ascophyllum nodosum
Medcalf, D. G., Schneider, T. L., & Barnett, R. W. (1978) · Carbohydrate Research · doi:10.1016/s0008-6215(00)83249-8 · Cited by 20 · see citing works
Interaction of Fucoidan fromPelvetia fastigiatawith Surface Antigens of Hepatitis B and Woodchuck Hepatitis Viruses
Venkateswaran, P. S., Millman, I., & Blumberg, B. S. (1989) · Planta Medica · doi:10.1055/s-2006-962000 · Cited by 20 · see citing works
sulfated polysaccharides from Durvillaea antarctica
Matsuhiro, B., Zu�iga, E., Jashés, M., & Guacucano, M. (1996) · Hydrobiologia · doi:10.1007/bf00018679 · Cited by 19 · see citing works
Structural studies of the water-soluble fucan from lessonia nigrescens
Percival, E. E., Jara, M. F. V., & Weigel, H. (1984) · Carbohydrate Research · doi:10.1016/0008-6215(84)85163-0 · Cited by 10 · see citing works
Medical and Biotechnological Applications of Marine Macroalgal Polysaccharides
Renn, D. W. (1993) · Springer eBooks · doi:10.1007/978-1-4899-2391-2_6 · Cited by 9 · see citing works

Flagged first, then by citations

Sorted by citations

Fucoidan: Structure and bioactivity
Li, B., Lu, F., Wei, X., & Zhao, R. (2008) · Molecules · doi:10.3390/molecules13081671 · Cited by 1,383 · see citing works
Chemical structures and bioactivities of sulfated polysaccharides from marine algae
Jiao, G., Yu, G., Zhang, J., & Ewart, H. S. (2011) · Marine Drugs · doi:10.3390/md9020196 · Cited by 1,054 · see citing works
Biological activities and potential health benefits of sulfated polysaccharides derived from marine algae
Wijesekara, I., Pangestuti, R., & Kim, S.-K. (2011) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2010.10.062 · Cited by 992 · see citing works
Medicinal and pharmaceutical uses of seaweed natural products: A review
Smit, A. J. (2004) · Journal of Applied Phycology · doi:10.1023/b:japh.0000047783.36600.ef · Cited by 806 · see citing works
Important Determinants for Fucoidan Bioactivity: A Critical Review of Structure-Function Relations and Extraction Methods for Fucose-Containing Sulfated Polysaccharides from Brown Seaweeds
Ale, M. T., Mikkelsen, J. D., & Meyer, A. S. (2011) · Marine Drugs · doi:10.3390/md9102106 · Cited by 779 · see citing works
Sulfated fucans, fresh perspectives: Structures, functions, and biological properties of sulfated fucans and an overview of enzymes active toward this class of polysaccharide
Berteau, O. (2003) · Glycobiology · doi:10.1093/glycob/cwg058 · Cited by 769 · see citing works
Antioxidant activity of sulfated polysaccharide fractions extracted from Laminaria japonica
Wang, J., Zhang, Q., Zhang, Z., & Li, Z. (2007) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2007.10.003 · Cited by 745 · see citing works
Marine Polysaccharides from Algae with Potential Biomedical Applications
Raposo, M. F. D. J., Morais, A. M. M. B., & Morais, R. M. S. C. (2015) · Marine Drugs · doi:10.3390/md13052967 · Cited by 693 · see citing works
A review of bioactive plant polysaccharides: Biological activities, functionalization, and biomedical applications
Liu, J., Willför, S. M., & Xu, C. (2014) · Bioactive Carbohydrates and Dietary Fibre · doi:10.1016/j.bcdf.2014.12.001 · Cited by 641 · see citing works
Sulfated Seaweed Polysaccharides as Multifunctional Materials in Drug Delivery Applications
Cunha, L., & Grenha, A. (2016) · Marine Drugs · doi:10.3390/md14030042 · Cited by 619 · see citing works
Bioactive potential and possible health effects of edible brown seaweeds
Gupta, S., & Abu-Ghannam, N. (2011) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2011.03.011 · Cited by 608 · see citing works
Characterization of polysaccharides extracted from brown seaweeds
Rioux, L.-E., Turgeon, S. L., & Beaulieu, M. (2007) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2007.01.009 · Cited by 604 · see citing works
Biological Activities of Fucoidan and the Factors Mediating Its Therapeutic Effects: A Review of Recent Studies
Wang, Y., Xing, M., Cao, Q., Ji, A., Liang, H., & Song, S. (2019) · Marine Drugs · doi:10.3390/md17030183 · Cited by 514 · see citing works
Screening for bioactive compounds from algae
Plaza, M., Santoyo, S., Jaime, L., Reina, G. G.-B., Herrero, M., Señoráns, F. J., & Ibáñez, E. (2009) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2009.03.016 · Cited by 493 · see citing works
The cell wall polysaccharide metabolism of the brown alga Ectocarpus siliculosus. Insights into the evolution of extracellular matrix polysaccharides in Eukaryotes
Michel, G., Tonon, T., Scornet, D., Cock, J. M., & Kloareg, B. (2010) · New Phytologist · doi:10.1111/j.1469-8137.2010.03374.x · Cited by 419 · see citing works
Polysaccharide biological response modifiers
Leung, M. Y. K., Liu, C., Koon, J. C. M., & Fung, K. (2006) · Immunology Letters · doi:10.1016/j.imlet.2006.01.009 · Cited by 410 · see citing works
Natural antioxidants from some fruits, seeds, foods, natural products, and associated health benefits: An update
Rahaman, M. M., Hossain, R., Herrera‐Bravo, J., Islam, M. T., Atolanı, O., Adeyemı, O. S., Owolodun, O. A., Kambizi, L., Daştan, S. D., Călina, D. C., et al. (2023) · Food Science & Nutrition · doi:10.1002/fsn3.3217 · Cited by 402 · see citing works
Therapeutic Effects of Fucoidan: A Review on Recent Studies
Luthuli, S., Wu, S., Cheng, Y., Zheng, X., Wu, M., & Tong, H. (2019) · Marine Drugs · doi:10.3390/md17090487 · Cited by 395 · see citing works
Focus on antivirally active sulfated polysaccharides: From structure–activity analysis to clinical evaluation
Ghosh, T., Chattopadhyay, K., Marschall, M., Karmakar, P., Mandal, P., & Ray, B. (2008) · Glycobiology · doi:10.1093/glycob/cwn092 · Cited by 393 · see citing works
The Antiviral Activities and Mechanisms of Marine Polysaccharides: An Overview
Wang, W., Wang, S., & Guan, H. (2012) · Marine Drugs · doi:10.3390/md10122795 · Cited by 386 · see citing works
Fucoidans from brown seaweeds: an update on structures, extraction techniques and use of enzymes as tools for structural elucidation
Ale, M. T., & Meyer, A. S. (2013) · RSC Adv. · doi:10.1039/c3ra23373a · Cited by 381 · see citing works
Microwave assisted extraction of sulfated polysaccharides (fucoidan) from Ascophyllum nodosum and its antioxidant activity
Yuan, Y., & Macquarrie, D. (2015) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2015.04.057 · Cited by 371 · see citing works
Immunomodulatory and Anti-Inflammatory Effects of Fucoidan: A Review
Apostolova, E., Lukova, P., Baldzhieva, A., Katsarov, P., Nikolova, M., Iliev, I. N., Peychev, L. P., Trică, B., Oancea, F., Delattre, C., et al. (2020) · Polymers · doi:10.3390/polym12102338 · Cited by 350 · see citing works
Fucoidan Structure and Activity in Relation to Anti-Cancer Mechanisms
van Weelden, G. H., Bobiński, M. S., Okła, K., van Weelden, W. J., Romano, A., & Pijnenborg, J. M. A. (2019) · Marine Drugs · doi:10.3390/md17010032 · Cited by 336 · see citing works
A review about brown algal cell walls and fucose-containing sulfated polysaccharides: Cell wall context, biomedical properties and key research challenges
Deniaud-Bouët, E., Hardouin, K., Potin, P., Kloareg, B., & Hervé, C. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.07.082 · Cited by 320 · see citing works
Chemical and enzymatic fractionation of cell walls from Fucales: insights into the structure of the extracellular matrix of brown algae
Deniaud-Bouët, E., Kervarec, N., Michel, G., Tonon, T., Kloareg, B., & Hervé, C. (2014) · Annals of Botany · doi:10.1093/aob/mcu096 · Cited by 317 · see citing works
Antiviral Potential of Algae Polysaccharides Isolated from Marine Sources: A Review
Ahmadi, A., Moghadamtousi, S. Z., AbuBakar, S., & Zandi, K. (2015) · BioMed Research International · doi:10.1155/2015/825203 · Cited by 309 · see citing works
Isolation of fucoidan from Sargassum polycystum brown algae: Structural characterization, in vitro antioxidant and anticancer activity
Palanisamy, S., Vinosha, M., Marudhupandi, T., Rajasekar, P., & Prabhu, N. M. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.03.182 · Cited by 273 · see citing works
Antiviral surfaces and coatings and their mechanisms of action
Rakowska, P. D., Tiddia, M., Faruqui, N., Bankier, C., Pei, Y., Pollard, A. J., Zhang, J., & Gilmore, I. S. (2021) · Communications Materials · doi:10.1038/s43246-021-00153-y · Cited by 271 · see citing works
The seasonal variation of fucoidan within three species of brown macroalgae
Fletcher, H. R., Biller, P., Ross, A. B., & Adams, J. M. M. (2016) · Algal Research · doi:10.1016/j.algal.2016.10.015 · Cited by 270 · see citing works
A highly regular fraction of a fucoidan from the brown seaweed Fucus distichus L.
Bilan, M. I., Grachev, A. A., Ustuzhanina, N. E., Shashkov, A. S., Nifantiev, N. E., & Usov, A. I. (2004) · Carbohydrate Research · doi:10.1016/j.carres.2003.10.028 · Cited by 255 · see citing works
Bioactive Polysaccharides from Seaweeds
Hentati, F., Tounsi, L., Djomdi, D., Pierre, G., Delattre, C., Ursu, A. V., Fendri, I., Abdelkafi, S., & Michaud, P. (2020) · Molecules · doi:10.3390/molecules25143152 · Cited by 254 · see citing works
Effects of molecular weight and hydrolysis conditions on anticancer activity of fucoidans from sporophyll of Undaria pinnatifida
Yang, C., Chung, D., Shin, I.-S., Lee, H., Kim, J., Lee, Y., & You, S. (2008) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2008.08.006 · Cited by 254 · see citing works
Fucoidan from New Zealand Undaria pinnatifida: Monthly variations and determination of antioxidant activities
Mak, W., Hamid, N., Liu, T., Lu, J., & White, W. L. (2013) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2013.02.047 · Cited by 253 · see citing works
The Evolution Road of Seaweed Aquaculture: Cultivation Technologies and the Industry 4.0
García‐Poza, S., Leandro, A., Cotas, C., Cotas, J., Marques, J. C., Pereira, L., & Gonçalves, A. M. M. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17186528 · Cited by 252 · see citing works
Fucoidans as a natural bioactive ingredient for functional foods
Vo, T., & Kim, S. (2012) · Journal of Functional Foods · doi:10.1016/j.jff.2012.08.007 · Cited by 237 · see citing works
Carbohydrates From Seaweeds
Stiger‐Pouvreau, V., Bourgougnon, N., & Deslandes, É. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802772-1.00008-7 · Cited by 226 · see citing works
Structure characterization and antioxidant activity of fucoidan isolated from Undaria pinnatifida grown in New Zealand
Koh, H. S. A., Lu, J., & Zhou, W. (2019) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.02.040 · Cited by 221 · see citing works
Seaweed polysaccharides and their potential biomedical applications
Venkatesan, J., Lowe, B., Anil, S., Manivasagan, P., Kheraif, A. A. A., Kang, K., & Kim, S. (2015) · Starch - Stärke · doi:10.1002/star.201400127 · Cited by 216 · see citing works
Further studies on the composition and structure of a fucoidan preparation from the brown alga Saccharina latissima
Bilan, M. I., Grachev, A. A., Shashkov, A. S., Kelly, M. S., Sanderson, C. J., Nifantiev, N. E., & Usov, A. I. (2010) · Carbohydrate Research · doi:10.1016/j.carres.2010.07.009 · Cited by 215 · see citing works
Structure and antiviral activity of sulfated fucans from Stoechospermum marginatum
Adhikari, U., Mateu, C. G., Chattopadhyay, K., Pujol, C. A., Damonte, E. B., & Ray, B. (2006) · Phytochemistry · doi:10.1016/j.phytochem.2006.05.024 · Cited by 213 · see citing works
Self-citation
Algal fucoidan: structural and size-dependent bioactivities and their perspectives
Morya, V. K., Kim, J.-E., & Kim, E.-K. (2011) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-011-3666-8 · Cited by 208 · see citing works
Antioxidant activity of sulfated polysaccharide fractions extracted from Undaria pinnitafida in vitro
Hu, T., Liú, D., Chen, Y., Wu, J., & Wang, S. (2009) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2009.12.004 · Cited by 205 · see citing works
Structural Features and Antiviral Activity of Sulphated Fucans from the Brown Seaweed Cystoseira Indica
Mandal, P., Mateu, C. G., Chattopadhyay, K., Pujol, C. A., Damonte, E. B., & Ray, B. (2007) · Antiviral chemistry & chemotherapy · doi:10.1177/095632020701800305 · Cited by 205 · see citing works
Self-citation
Microwave assisted hydrothermal extraction of polysaccharides from Ulva prolifera: Functional properties and bioactivities
Yuan, Y., Xu, X., Jing, C., Zou, P., Zhang, C., & Li, Y. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.11.061 · Cited by 197 · see citing works
Bioactive compounds in seaweeds: An overview of their biological properties and safety
Rengasamy, K. R. R., Mahomoodally, M. F., Aumeeruddy, M. Z., Zengin, G., Xiao, J., & Kim, D. H. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.111013 · Cited by 194 · see citing works
Herpes Simplex Virus Cell Entry Mechanisms: An Update
Madavaraju, K., Koganti, R., Volety, I., Yadavalli, T., & Shukla, D. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.617578 · Cited by 194 · see citing works
Marine fucoidans: Structural, extraction, biological activities and their applications in the food industry
Mensah, E. O., Kanwugu, O. N., Panda, P. K., & Adadi, P. (2023) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2023.108784 · Cited by 194 · see citing works
Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects
Fedorov, S., Ermakova, S., Zvyagintseva, T., & Stonik, V. (2013) · Marine Drugs · doi:10.3390/md11124876 · Cited by 189 · see citing works
Effect of different non-conventional extraction methods on the antibacterial and antiviral activity of fucoidans extracted from Nizamuddinia zanardinii
Alboofetileh, M., Rezaei, M., Tabarsa, M., Rittà, M., Donalisio, M., Mariatti, F., You, S., Lembo, D., & Cravotto, G. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.11.201 · Cited by 185 · see citing works
Antiviral activity of sulfated polysaccharides from marine algae and its application in combating COVID-19: Mini review
Hans, N., Malik, A., & Naik, S. N. (2020) · Bioresource Technology Reports · doi:10.1016/j.biteb.2020.100623 · Cited by 184 · see citing works
Virucidal activity of polysaccharide extracts from four algal species against herpes simplex virus
Harden, E. A., Falshaw, R., Carnachan, S., Kern, E. R., & Prichard, M. N. (2009) · Antiviral Research · doi:10.1016/j.antiviral.2009.06.007 · Cited by 183 · see citing works
The effect of fucoidan from brown seaweed Sargassum wightii on WSSV resistance and immune activity in shrimp Penaeus monodon (Fab)
Immanuel, G., Madasamy, S., Marudhupandi, T., Radhakrishnan, S., & Palavesam, A. (2012) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2012.01.003 · Cited by 181 · see citing works
Fucoidans and fucoidanases—focus on techniques for molecular structure elucidation and modification of marine polysaccharides
Holtkamp, A. D., Kelly, S., Ulber, R., & Lang, S. (2009) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-008-1790-x · Cited by 175 · see citing works
Structure and Antiviral Activity of the Galactofucan Sulfates Extracted from Undaria Pinnatifida (Phaeophyta)
Hemmingson, J. A., Falshaw, R., Furneaux, R. H., & Thompson, K. (2006) · Journal of Applied Phycology · doi:10.1007/s10811-006-9096-9 · Cited by 171 · see citing works
Antibacterial activities of some marine algae from the Aegean Sea (Turkey)
Taşkın, E., Ozturk, M., Taşkın, E., & Kurt, O. (2007) · AFRICAN JOURNAL OF BIOTECHNOLOGY · doi:10.5897/ajb2007.000-2439 · Cited by 167 · see citing works
Microalgae polysaccharides: the new sustainable bioactive products for the development of plant bio-stimulants?
Chanda, M. J., Merghoub, N., & Arroussi, H. E. (2019) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-019-2745-3 · Cited by 166 · see citing works
Seaweed carbohydrates
Rioux, L., & Turgeon, S. L. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-418697-2.00007-6 · Cited by 162 · see citing works
Structural investigation of a fucoidan containing a fucose-free core from the brown seaweed, Hizikia fusiforme
Li, B., Wei, X.-J., Sun, J.-L., & Xu, S.-Y. (2006) · Carbohydrate Research · doi:10.1016/j.carres.2006.03.035 · Cited by 161 · see citing works
Structural studies on a novel fucogalactan sulfate extracted from the brown seaweed Laminaria japonica
Wang, J., Zhang, Q., Zhang, Z., Zhang, H., & Niu, X. (2010) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2010.05.010 · Cited by 159 · see citing works
Immunomodulating Activity of Arabinogalactan and Fucoidan In Vitro
Choi, E., Kim, A.-J., Kim, Y.-O., & Hwang, J. (2005) · Journal of Medicinal Food · doi:10.1089/jmf.2005.8.446 · Cited by 158 · see citing works
Physico-chemical characterization and pharmacological evaluation of sulfated polysaccharides from three species of Mediterranean brown algae of the genus Cystoseira
Ammar, H. H., Lajili, S., Said, R. B., Cerf, D. L., Bouraoui, A., & Majdoub, H. (2015) · DARU Journal of Pharmaceutical Sciences · doi:10.1186/s40199-015-0089-6 · Cited by 158 · see citing works
Macroalgal biorefinery concepts for the circular bioeconomy: A review on biotechnological developments and future perspectives
Kostas, E. T., Adams, J. M. M., Ruíz, H. A., Durán-Jiménez, G., & Lye, G. J. (2021) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2021.111553 · Cited by 158 · see citing works
Partial characterization and anticoagulant activity of a heterofucan from the brown seaweed Padina gymnospora
Silva, T. M. A., Alves, L. G., Queiroz, K. C. S., Santos, M. G. L., Marques, C. T., Chavante, S. F., Rocha, H. A. O., & Leite, E. L. (2005) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2005000400005 · Cited by 157 · see citing works
Anti-proliferative activity of oversulfated fucoidan from commercially cultured Cladosiphon okamuranus TOKIDA in U937 cells
Teruya, T., Konishi, T., Uechi, S., Tamaki, H., & Tako, M. (2007) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2007.02.010 · Cited by 156 · see citing works
Structural and Hemostatic Activities of a Sulfated Galactofucan from the Brown Alga Spatoglossum schroederi
Rocha, H. A. O., Moraes, F. A., Trindade, E. D. S., Franco, C. R. C., Torquato, R. J. S., Veiga, S. S., Valente, A. P., Mourão, P. A. S., Leite, E. L., Nader, H. B., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501124200 · Cited by 156 · see citing works
Antioxidant and antiproliferative activities of heterofucans from the seaweed Sargassum filipendula
Costa, L. S., Fidelis, G. P., Telles, C. B. S., Dantas-Santos, N., Camara, R. B. G., Cordeiro, S. L., Costa, M. S. S. P., Almeida-Lima, J., Melo-Silveira, R. F., Oliveira, R. M., et al. (2011) · Marine Drugs · doi:10.3390/md9060952 · Cited by 155 · see citing works
Functional polysaccharides of fucoidan, laminaran and alginate from Malaysian brown seaweeds (Sargassum polycystum, Turbinaria ornata and Padina boryana)
Fauziee, N. A. M., Chang, L. S., Mustapha, W. A. W., Nor, A. M., & Lim, S. J. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.11.067 · Cited by 154 · see citing works
Monthly changes in the content and monosaccharide composition of fucoidan from Undaria pinnatifida (Laminariales, Phaeophyta)
Skriptsova, A. V., Shevchenko, N. M., Николаевна, З. Т., & Imbs, T. I. (2009) · Journal of Applied Phycology · doi:10.1007/s10811-009-9438-5 · Cited by 152 · see citing works
Seaweed as a Source of Natural Antioxidants: Therapeutic Activity and Food Applications
Kumar, Y., Tarafdar, A., & Badgujar, P. C. (2021) · Journal of Food Quality · doi:10.1155/2021/5753391 · Cited by 152 · see citing works
Fucans, but Not Fucomannoglucuronans, Determine the Biological Activities of Sulfated Polysaccharides from Laminaria saccharina Brown Seaweed
Croci, D. O., Cumashi, A., Ushakova, N. A., Preobrazhenskaya, M. E., Piccoli, A. L., Jr., Totani, L., Ustyuzhanina, N. E., Bilan, M. I., Usov, A. I., Grachev, A. A., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017283 · Cited by 151 · see citing works
Enzyme-Assisted Fucoidan Extraction from Brown Macroalgae Fucus distichus subsp. evanescens and Saccharina latissima
Nguyen, T. T., Mikkelsen, M. D., Tran, V. H. N., Trang, V. T. D., Rhein‐Knudsen, N., Holck, J., Rasin, A. B., Cao, H. T. T., Van, T. T. T., & Meyer, A. S. (2020) · Marine Drugs · doi:10.3390/md18060296 · Cited by 150 · see citing works
A Review on Fucoidan Structure, Extraction Techniques, and Its Role as an Immunomodulatory Agent
Jayawardena, T. U., Nagahawatta, D. P., Fernando, I. P. S., Kim, Y.-T., Kim, J.-S., Kim, W.-S., Lee, J. S., & Jeon, Y.-J. (2022) · Marine Drugs · doi:10.3390/md20120755 · Cited by 149 · see citing works
Characteristics and antioxidant of Ulva intestinalis sulphated polysaccharides extracted with different solvents
Peasura, N., Laohakunjit, N., Kerdchoechuen, O., & Wanlapa, S. (2015) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2015.09.030 · Cited by 149 · see citing works
A Comprehensive and Comparative Analysis of the Fucoidan Compositional Data Across the Phaeophyceae
Ponce, N. M. A., & Stortz, C. A. (2020) · Frontiers in Plant Science · doi:10.3389/fpls.2020.556312 · Cited by 148 · see citing works
Self-citation
Inhibition of Influenza A Virus Infection by Fucoidan Targeting Viral Neuraminidase and Cellular EGFR Pathway
Wang, W., Wu, J., Zhang, X., Hao, C., Zhao, X., Jiao, G., Shan, X., Tai, W., & Yu, G. (2017) · Scientific Reports · doi:10.1038/srep40760 · Cited by 147 · see citing works
Antioxidant activities of crude extracts of fucoidan extracted from Sargassum glaucescens by a compressional-puffing-hydrothermal extraction process
Huang, C.-Y., Wu, S.-J., Yang, W.-N., Kuan, A.-W., & Chen, C.-Y. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2015.11.100 · Cited by 143 · see citing works
Preparation and characterization of chitosan-natural nano hydroxyapatite-fucoidan nanocomposites for bone tissue engineering
Lowe, B., Venkatesan, J., Anil, S., Shim, M. S., & Kim, S. (2016) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2016.02.054 · Cited by 143 · see citing works
An Unfractionated Fucoidan from Ascophyllum nodosum: Extraction, Characterization, and Apoptotic Effects in Vitro
Foley, S. A., Szegezdi, E., Mulloy, B., Samali, A., & Tuohy, M. G. (2011) · Journal of Natural Products · doi:10.1021/np200124m · Cited by 142 · see citing works
Cell Wall Polysaccharides of Marine Algae
Synytsya, A., Čopı́ková, J., Kim, W. J., & Park, Y. I. (2015) · Springer eBooks · doi:10.1007/978-3-642-53971-8_22 · Cited by 142 · see citing works
Multifunctional role of fucoidan, sulfated polysaccharides in human health and disease: A journey under the sea in pursuit of potent therapeutic agents
Pradhan, B., Patra, S., Nayak, R., Behera, C., Dash, S. R., Nayak, S., Sahu, B. B., Bhutia, S. K., & Jena, M. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.09.019 · Cited by 142 · see citing works
Bioactive Compounds and Properties of Seaweeds—A Review
Pal, A., Kamthania, M., & Kumar, A. (2014) · OALib · doi:10.4236/oalib.1100752 · Cited by 141 · see citing works
Fucoidans — sulfated polysaccharides of brown algae
Usov, A. I., & Bilan, M. I. (2009) · Russian Chemical Reviews · doi:10.1070/rc2009v078n08abeh004063 · Cited by 141 · see citing works
An overview of extraction and purification techniques of seaweed dietary fibers for immunomodulation on gut microbiota
Praveen, M. A., Parvathy, K. R. K., Balasubramanian, P., & Jayabalan, R. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.08.011 · Cited by 140 · see citing works
Polysaccharides Derived From the Brown Algae Lessonia nigrescens Enhance Salt Stress Tolerance to Wheat Seedlings by Enhancing the Antioxidant System and Modulating Intracellular Ion Concentration
Zou, P., Lu, X., Zhao, H., Yuan, Y., Meng, L., Zhang, C., & Li, Y. (2019) · Frontiers in Plant Science · doi:10.3389/fpls.2019.00048 · Cited by 135 · see citing works
In vitro antioxidant and antibacterial activity of sulfated polysaccharides isolated from Spatoglossum asperum
Palanisamy, S., Vinosha, M., Marudhupandi, T., Rajasekar, P., & Prabhu, N. M. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.04.085 · Cited by 133 · see citing works
Molecular characteristics and antioxidant activity of laminarin extracted from the seaweed species Laminaria hyperborea, using hydrothermal-assisted extraction and a multi-step purification procedure
Rajauria, G., Ravindran, R., García‐Vaquero, M., Rai, D. K., Sweeney, T., & O’Doherty, J. V. (2020) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2020.106332 · Cited by 132 · see citing works
Advances in Extraction Methods to Recover Added-Value Compounds from Seaweeds: Sustainability and Functionality
Matos, G. S., Pereira, S. G., Genisheva, Z. A., Gomes, A., Teixeira, J. A., & Rocha, C. M. R. (2021) · Foods · doi:10.3390/foods10030516 · Cited by 132 · see citing works
Different extraction methods bring about distinct physicochemical properties and antioxidant activities of Sargassum fusiforme fucoidans
Liu, J., Wu, S., Chen, L., Li, Q., Shen, Y.-Z., Li, J., Zhang, X., Chen, P., Wu, M., Choi, J., et al. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.11.113 · Cited by 131 · see citing works
Fucoidan, a sulfated polysaccharide, inhibits adipogenesis through the mitogen-activated protein kinase pathway in 3T3-L1 preadipocytes
Kim, K., Lee, O., & Lee, B.-Y. (2010) · Life Sciences · doi:10.1016/j.lfs.2010.03.010 · Cited by 129 · see citing works
A comprehensive review on the health benefits and nutritional significance of fucoidan polysaccharide derived from brown seaweeds in human, animals and aquatic organisms
Saeed, M., Arain, M. A., Fazlani, S. A., Marghazani, I. B., Umar, M., Soomro, J., Bhutto, Z. A., Soomro, F., Noreldin, A. E., El-Hack, M. E. A., et al. (2021) · Aquaculture Nutrition · doi:10.1111/anu.13233 · Cited by 126 · see citing works
Hypolipidemic effect of fucoidan from Laminaria japonica in hyperlipidemic rats
Huang, L., Wen, K., Gao, X., & Liu, Y. (2010) · Pharmaceutical Biology · doi:10.3109/13880200903150435 · Cited by 125 · see citing works
Chemical structure and antiviral activity of the sulfated heterorhamnan isolated from the green seaweed Gayralia oxysperma
Cassolato, J. E. F., Noseda, M. D., Pujol, C. A., Pellizzari, F., Damonte, E. B., & Duarte, M. E. R. (2008) · Carbohydrate Research · doi:10.1016/j.carres.2008.09.014 · Cited by 124 · see citing works
Self-citation
Effects of dietary fucoidan on the blood constituents, anti-oxidation and innate immunity of juvenile yellow catfish (Pelteobagrus fulvidraco)
Yang, Q., Yang, R., Li, M., Zhou, Q., Liang, X.-P., & Elmada, Z. C. (2014) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2014.09.003 · Cited by 123 · see citing works
Fucoidans in Nanomedicine
Chollet, L., Saboural, P., Chauvierre, C., Villemin, J.-N., Letourneur, D., & Chaubet, F. (2016) · Marine Drugs · doi:10.3390/md14080145 · Cited by 122 · see citing works
Fucoidan from Marine Macroalgae: Biological Actions and Applications in Regenerative Medicine, Drug Delivery Systems and Food Industry
Anisha, G. S., Padmakumari, S., Patel, A. K., Pandey, A., & Singhania, R. R. (2022) · Bioengineering · doi:10.3390/bioengineering9090472 · Cited by 121 · see citing works
Health benefits and potential applications of fucoidan (FCD) extracted from brown seaweeds in aquaculture: An updated review
Abdel‐Latif, H. M. R., Dawood, M. A. O., Alagawany, M. M., Faggio, C., Nowosad, J., & Kucharczyk, D. (2022) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2022.01.039 · Cited by 118 · see citing works
The system of fucoidans from the brown seaweed Dictyota dichotoma: Chemical analysis and antiviral activity
Rabanal, M., Ponce, N. M. A., Navarro, D. A., Gomez, R. M., & Stortz, C. A. (2013) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2013.10.019 · Cited by 117 · see citing works
Self-citation
Heterofucans from Dictyota menstrualis have anticoagulant activity
Albuquerque, I. R. L., Queiroz, K. C. S., Alves, L. G., dos Santos, E. A., Leite, E. L., & Rocha, H. A. O. (2004) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2004000200002 · Cited by 116 · see citing works
Structural characterization and antiviral activity of two fucoidans from the brown algae Sargassum henslowianum
Sun, Q., Li, Y., Ni, L., Li, Y., Cui, Y., Jiang, S.-L., Xie, E., Du, J., Dèng, F., & Dong, C.-X. (2019) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.115487 · Cited by 114 · see citing works

Structure and Antiviral Activity of the Galactofucan Sulfates Extracted from Undaria Pinnatifida (Phaeophyta)
Hemmingson, J. A., Falshaw, R., Furneaux, R. H., & Thompson, K. (2006) · Journal of Applied Phycology · doi:10.1007/s10811-006-9096-9 · Cited by 171 · see citing works
The system of fucoidans from the brown seaweed Dictyota dichotoma: Chemical analysis and antiviral activity
Rabanal, M., Ponce, N. M. A., Navarro, D. A., Gomez, R. M., & Stortz, C. A. (2013) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2013.10.019 · Cited by 117 · see citing works
Self-citation
Fucoidans from the phaeophyta Scytosiphon lomentaria: Chemical analysis and antiviral activity of the galactofucan component
Ponce, N. M. A., Flores, M. L., Pujol, C. A., Becerra, M. B., Navarro, D. A., Córdoba, O. L., Damonte, E. B., & Stortz, C. A. (2019) · Carbohydrate Research · doi:10.1016/j.carres.2019.04.004 · Cited by 68 · see citing works
Self-citation
Structural Features and Antiviral Activity of Sulphated Fucans from the Brown Seaweed Cystoseira Indica
Mandal, P., Mateu, C. G., Chattopadhyay, K., Pujol, C. A., Damonte, E. B., & Ray, B. (2007) · Antiviral chemistry & chemotherapy · doi:10.1177/095632020701800305 · Cited by 205 · see citing works
Self-citation
Extraction and Bioactivity assessment of Fucoidan from Brown seaweed
Ale, M. T., Maruyama, H., Tamauchi, H., & Meyer, A. S. (2011)

Authors: Ponce, N. M. A., Pujol, C. A., Damonte, E. B., Flores, M. L., & Stortz, C. A.
Affiliations: Universidad de Buenos Aires (AR)
Corresponding author: Stortz, Carlos A.
ORCID: Ponce, Nora M.A.
Damonte, Elsa B.
Stortz, Carlos A.
Venue: Carbohydrate Research
Publisher: Elsevier BV
Published: 2003-01
Volume: 338
Issue: 2
Pages: 153-165
ISSN: 0008-6215 (ISSN-L)
DOI: 10.1016/s0008-6215(02)00403-2
OpenAlex: W1981755056
Cited by: 484
References: 56
Citations by year: 2026: 5 · 2025: 21 · 2024: 20 · 2023: 14 · 2022: 40 · 2021: 40 · 2020: 32 · 2019: 23 · 2018: 24 · 2017: 25 · 2016: 18 · 2015: 24 · 2014: 22 · 2013: 23 · 2012: 21
FWCI: 11.76
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Carbohydrate Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
Life Sciences › Agricultural and Biological Sciences › Plant Science › Polysaccharides and Plant Cell Walls
Keywords: fucoidan, brown algae, antiviral activity, herpes simplex virus type 1, herpes simplex virus type 2, sulfate esters, uronic acid, extraction methods, sulfated polysaccharides
MeSH terms: Animals, Antiviral Agents, Cell Survival, Chlorocebus aethiops, Chemical Fractionation, Polysaccharides, Seaweed, Vero Cells, Molecular Structure, Herpesvirus 2, Human, Herpesvirus 1, Human, Inhibitory Concentration 50

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Fucoidans from the brown seaweed Adenocystis utricularis: extraction methods, antiviral activity and structural studies

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks