Cited by 280Atherosclerosis and Cardiovascular DiseasesCerebrovascular and Carotid Artery DiseasesCholesterol and Lipid Metabolism

Collagen synthesis in atherosclerosis: too much and not enough

Rekhter, M·1999·Cardiovascular Research

Abstract

Fibrillar collagen is a critical component of atherosclerotic lesions. Uncontrolled collagen accumulation leads to arterial stenosis, while excessive collagen breakdown combined with inadequate synthesis weakens plaques thereby making them prone to rupture. This review discusses cellular sources of collagen synthesis in atherosclerosis, local and systemic factors modulating collagen gene expression, as well as temporal and spatial patterns of collagen production in human and experimental atherosclerotic lesions.

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Crossref · 10.1016/s0008-6363(98)00321-6

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121 of 121 references verified0 citation errors · 0 not checkable

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  • In vitro studies, including proteomic analysis of the secretome of lipid-loaded VSMCs and induction of collagen synthesis by VSMCs in culture by TGFβ, PDGF, IL-1, AngII, cholesterol, homocysteine and mechanical stretch, provide further evidence that VSMCs are the major source of collagens.

    “Further evidence that VSMCs are the major source of collagens comes from studies in vitro , including proteomic analysis of the secretome of lipid-loaded VSMCs 109 and induction of collagen synthesis by VSMCs in culture by TGFβ , PDGF, IL-1, AngII, cholesterol, homocysteine and mechanical stretch 144,145”

    From Vascular smooth muscle cells in atherosclerosis (2019) · cites this paper as [145]

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Authors
Rekhter, M.
Corresponding author
Rekhter, M
Venue
Cardiovascular Research
Published
1999-02-01
Volume
41
Issue
2
Pages
376-384
ISSN
0008-6363 (ISSN-L)
OpenAlex
W2126544076
Cited by
280
References
121
Citations by year
2026: 5 · 2025: 13 · 2024: 14 · 2023: 13 · 2022: 11 · 2021: 22 · 2020: 18 · 2019: 7 · 2018: 12 · 2017: 4 · 2016: 12 · 2015: 12 · 2014: 18 · 2013: 10 · 2012: 8
FWCI
2.51
Type
journal article
Language
en
Open access
closed
Locations
  • Cardiovascular Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cerebrovascular and Carotid Artery Diseases
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Keywords
collagen synthesis, atherosclerosis, fibrillar collagen, arterial stenosis, plaque rupture, collagen gene expression, vascular smooth muscle cells, collagen deposition, collagen degradation, atherosclerotic plaque
MeSH terms
Arteries, Arteriosclerosis, Collagen, Endothelium, Vascular, Homocysteine, Humans, Muscle, Smooth, Vascular

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