Collagen synthesis in atherosclerosis: too much and not enough
Abstract
Fibrillar collagen is a critical component of atherosclerotic lesions. Uncontrolled collagen accumulation leads to arterial stenosis, while excessive collagen breakdown combined with inadequate synthesis weakens plaques thereby making them prone to rupture. This review discusses cellular sources of collagen synthesis in atherosclerosis, local and systemic factors modulating collagen gene expression, as well as temporal and spatial patterns of collagen production in human and experimental atherosclerotic lesions.
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In vitro studies, including proteomic analysis of the secretome of lipid-loaded VSMCs and induction of collagen synthesis by VSMCs in culture by TGFβ, PDGF, IL-1, AngII, cholesterol, homocysteine and mechanical stretch, provide further evidence that VSMCs are the major source of collagens.
“Further evidence that VSMCs are the major source of collagens comes from studies in vitro , including proteomic analysis of the secretome of lipid-loaded VSMCs 109 and induction of collagen synthesis by VSMCs in culture by TGFβ , PDGF, IL-1, AngII, cholesterol, homocysteine and mechanical stretch 144,145”
From Vascular smooth muscle cells in atherosclerosis (2019) · cites this paper as [145]
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Wang, H., Li, Z., Moore, S., et al. (1998) · International Journal of Experimental Pathology · doi:10.1046/j.1365-2613.1998.00048.x · Cited by 4 · see citing works
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Grootaert, M. O., da Costa Martins, P. A., Bitsch, N., Pintelon, I., De Meyer, G. R., Martinet, W., & Schrijvers, D. M. (2015) · Autophagy · doi:10.1080/15548627.2015.1096485 · Cited by 267 · see citing works
Previtera, M. L., & Sengupta, A. (2015) · PLOS ONE · doi:10.1371/journal.pone.0145813 · Cited by 176 · see citing works
- Authors
- Rekhter, M.
- Corresponding author
- Rekhter, M
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-02-01
- Volume
- 41
- Issue
- 2
- Pages
- 376-384
- ISSN
- 0008-6363 (ISSN-L)
- OpenAlex
- W2126544076
- Cited by
- 280
- References
- 121
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 14 · 2023: 13 · 2022: 11 · 2021: 22 · 2020: 18 · 2019: 7 · 2018: 12 · 2017: 4 · 2016: 12 · 2015: 12 · 2014: 18 · 2013: 10 · 2012: 8
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cardiovascular Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cerebrovascular and Carotid Artery Diseases
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Keywords
- collagen synthesis, atherosclerosis, fibrillar collagen, arterial stenosis, plaque rupture, collagen gene expression, vascular smooth muscle cells, collagen deposition, collagen degradation, atherosclerotic plaque
- MeSH terms
- Arteries, Arteriosclerosis, Collagen, Endothelium, Vascular, Homocysteine, Humans, Muscle, Smooth, Vascular
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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