Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis
Open accessAbstract
Autophagy is triggered in vascular smooth muscle cells (VSMCs) of diseased arterial vessels. However, the role of VSMC autophagy in cardiovascular disease is poorly understood. Therefore, we investigated the effect of defective autophagy on VSMC survival and phenotype and its significance in the development of postinjury neointima formation and atherosclerosis. Tissue-specific deletion of the essential autophagy gene Atg7 in murine VSMCs (atg7−/− VSMCs) caused accumulation of SQSTM1/p62 and accelerated the development of stress-induced premature senescence as shown by cellular and nuclear hypertrophy, CDKN2A-RB-mediated G1 proliferative arrest and senescence-associated GLB1 activity. Transfection of SQSTM1-encoding plasmid DNA in Atg7+/+ VSMCs induced similar features, suggesting that accumulation of SQSTM1 promotes VSMC senescence. Interestingly, atg7−/− VSMCs were resistant to oxidative stress-induced cell death as compared to controls. This effect was attributed to nuclear translocation of the transcription factor NFE2L2 resulting in upregulation of several antioxidative enzymes. In vivo, defective VSMC autophagy led to upregulation of MMP9, TGFB and CXCL12 and promoted postinjury neointima formation and diet-induced atherogenesis. Lesions of VSMC-specific atg7 knockout mice were characterized by increased total collagen deposition, nuclear hypertrophy, CDKN2A upregulation, RB hypophosphorylation, and GLB1 activity, all features typical of cellular senescence. To conclude, autophagy is crucial for VSMC function, phenotype, and survival. Defective autophagy in VSMCs accelerates senescence and promotes ligation-induced neointima formation and diet-induced atherogenesis, implying that autophagy inhibition as therapeutic strategy in the treatment of neointimal stenosis and atherosclerosis would be unfavorable. Conversely, stimulation of autophagy could be a valuable new strategy in the treatment of arterial disease.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Loss of autophagy can also drive VSMC senescence.
“Loss of autophagy can also drive VSMC senescence 75 .”
From Vascular smooth muscle cells in atherosclerosis (2019) · cites this paper as [75]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351 · see citing works
Autophagy: Renovation of Cells and Tissues
Mizushima, N., & Komatsu, M. (2011) · Cell · doi:10.1016/j.cell.2011.10.026 · Cited by 6,467 · see citing works
Cellular senescence: when bad things happen to good cells
Campisi, J., & d'Adda di Fagagna, F. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2233 · Cited by 4,441 · see citing works
Loss of autophagy in the central nervous system causes neurodegeneration in mice
Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J.-I., Tanida, I., Ueno, T., Koike, M., Uchiyama, Y., Kominami, E., et al. (2006) · Nature · doi:10.1038/nature04723 · Cited by 3,500 · see citing works
Aging, Cellular Senescence, and Cancer
Campisi, J. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183653 · Cited by 2,954 · cited 3× · see citing works
“Moreover, atg7¡/¡ VSMCs show an increase in TGFB and CXCL12 expression, which is most likely related to the increase in migration potential and the development of a senescence-associated secretory phenotype.(29,30) Cellular senescence can be established by the activation of 2 different tumor suppressor pathways: TP53-…”
BackgroundKomatsu, M., Kurokawa, H., Waguri, S., Taguchi, K., Kobayashi, A., Ichimura, Y., Sou, Y., Ueno, I., Sakamoto, A., Tong, K. I., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2021 · Cited by 2,422 · see citing works
Impairment of starvation-induced and constitutive autophagy in <i>Atg7</i> -deficient mice
Komatsu, M., Waguri, S., Ueno, T., Iwata, J., Murata, S., Tanida, I., Ezaki, J., Mizushima, N., Ohsumi, Y., Uchiyama, Y., et al. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200412022 · Cited by 2,331 · see citing works
Oxidative stress and autophagy: The clash between damage and metabolic needs
Filomeni, G., De Zio, D., & Cecconi, F. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.150 · Cited by 2,195 · see citing works
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice.
Komatsu, M., Waguri, S., Koike, M., Sou, Y.-S., Ueno, T., Hara, T., Mizushima, N., Iwata, J.-I., Ezaki, J., Murata, S., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.035 · Cited by 2,124 · see citing works
Rubinsztein, D. C., Mariño, G., & Kroemer, G. (2011) · Cell · doi:10.1016/j.cell.2011.07.030 · Cited by 2,107 · see citing works
The machinery of macroautophagy
Feng, Y., He, D., Yao, Z., & Klionsky, D. J. (2014) · Cell Research · doi:10.1038/cr.2013.168 · Cited by 2,083 · see citing works
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
Tchkonia, T., Zhu, Y., van Deursen, J., Campisi, J., & Kirkland, J. L. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64098 · Cited by 1,774 · see citing works
Ink4a/Arf expression is a biomarker of aging
Krishnamurthy, J., Torrice, C., Ramsey, M. R., Kovalev, G. I., Al-Regaiey, K., Su, L., & Sharpless, N. E. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22475 · Cited by 1,486 · see citing works
Angiotensin II induces hypertrophy, not hyperplasia, of cultured rat aortic smooth muscle cells.
Geisterfer, A. A., Peach, M. J., & Owens, G. K. (1988) · Circulation Research · doi:10.1161/01.res.62.4.749 · Cited by 1,071 · see citing works
Wang (2012) · doi:10.1161/circresaha.111.261388 · Cited by 957 · see citing works
Lau, A., Wang, X.-J., Zhao, F. L., Villeneuve, N. F., Wu, T., Jiang, T., Sun, Z., White, E., & Zhang, D. D. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00248-10 · Cited by 851 · see citing works
Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia
Jung, H. S., Chung, K. W., Won Kim, J., Kim, J., Komatsu, M., Tanaka, K., Nguyen, Y. H., Kang, T. M., Yoon, K.-H., Kim, J.-W., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.08.013 · Cited by 647 · see citing works
Macrophage Autophagy Plays a Protective Role in Advanced Atherosclerosis
Liao, X., Sluimer, J. C., Wang, Y., Subramanian, M., Brown, K., Pattison, J. S., Robbins, J., Martinez, J., & Tabas, I. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.022 · Cited by 627 · see citing works
Matthews, C., Gorenne, I., Scott, S., Figg, N., Kirkpatrick, P., Ritchie, A., Goddard, M., & Bennett, M. (2006) · Circulation Research · doi:10.1161/01.res.0000233315.38086.bc · Cited by 615 · cited 1× · see citing works
“Different research groups have shown that VSMC senescence is present in atherosclerotic plaques and contributes to the pathogenesis of atherosclerosis.(21,32,53,54) Our observations confirm once more the dual role of VSMCs in atherosclerosis.”
BackgroundVascular Cell Senescence: Contribution to Atherosclerosis
Minamino, T., & Komuro, I. (2007) · Circulation Research · doi:10.1161/01.res.0000256837.40544.4a · Cited by 542 · see citing works
Newby, A. C. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.08.002 · Cited by 530 · see citing works
Phagocytosis of apoptotic cells by macrophages is impaired in atherosclerosis
Schrijvers, D. M., De Meyer, G. R. Y., Kockx, M. M., Herman, A. G., & Martinet, W. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000166517.18801.a7 · Cited by 509 · see citing works
Owens, G. K., Loeb, A. L., Gordon, D., & Thompson, M. M. (1986) · The Journal of Cell Biology · doi:10.1083/jcb.102.2.343 · Cited by 412 · see citing works
Rapamycin decelerates cellular senescence
Demidenko, Z. N., Zubova, S. G., Bukreeva, E. I., Pospelov, V. A., Pospelova, T. V., & Blagosklonny, M. V. (2009) · Cell Cycle · doi:10.4161/cc.8.12.8606 · Cited by 391 · see citing works
Martinet, W., & Meyer, G. R. Y. D. (2009) · Circulation Research · doi:10.1161/circresaha.108.188318 · Cited by 384 · see citing works
Self-citationZernecke, A., Schober, A., Bot, I., von Hundelshausen, P., Liehn, E. A., Moepps, B., Mericskay, M., Gierschik, P., Biessen, E. A. L., & Weber, C. (2005) · Circulation Research · doi:10.1161/01.res.0000162100.52009.38 · Cited by 364 · see citing works
Autophagy in cardiovascular biology
Lavandero, S., Chiong, M., Rothermel, B. A., & Hill, J. A. (2015) · Journal of Clinical Investigation · doi:10.1172/jci73943 · Cited by 331 · see citing works
Jia, G., Cheng, G., Gangahar, D. M., & Agrawal, D. K. (2006) · Immunology and Cell Biology · doi:10.1111/j.1440-1711.2006.01454.x · Cited by 299 · see citing works
Meyer, G. R. Y. D., Grootaert, M. O. J., Michiels, C. F., Kurdi, A., Schrijvers, D. M., & Martinet, W. (2015) · Circulation Research · doi:10.1161/circresaha.116.303804 · Cited by 288 · see citing works
Self-citationCollagen synthesis in atherosclerosis: too much and not enough
Rekhter, M. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00321-6 · Cited by 280 · see citing works
Vascular Smooth Muscle Cell Sirtuin 1 Protects Against DNA Damage and Inhibits Atherosclerosis
Gorenne, I., Kumar, S., Gray, K., Figg, N. L., Yu, H., Mercer, J. R., & Bennett, M. R. (2012) · Circulation · doi:10.1161/circulationaha.112.124404 · Cited by 272 · see citing works
Autophagy Impairment Induces Premature Senescence in Primary Human Fibroblasts
Kang, H. T., Lee, K. B., Kim, S. Y., Choi, H. R., & Park, S. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023367 · Cited by 254 · see citing works
Cellular senescence in vivo: Its relevance in ageing and cardiovascular disease
Erusalimsky, J. D., & Kurz, D. J. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.04.010 · Cited by 252 · see citing works
Fujii, S., Hara, H., Araya, J., Takasaka, N., Kojima, J., Ito, S., Minagawa, S., Yumino, Y., Ishikawa, T., Numata, T., et al. (2012) · OncoImmunology · doi:10.4161/onci.20297 · Cited by 243 · see citing works
Salabei, J. K., Cummins, T. D., Singh, M., Jones, S. P., Bhatnagar, A., & Hill, B. G. (2013) · Biochemical Journal · doi:10.1042/bj20121344 · Cited by 228 · see citing works
Schober, A., Knarren, S., Lietz, M., Lin, E. A., & Weber, C. (2003) · Circulation · doi:10.1161/01.cir.0000099508.76665.9a · Cited by 198 · see citing works
Vascular smooth muscle cell senescence in atherosclerosis
GORENNE, I., KAVURMA, M., SCOTT, S., & BENNETT, M. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.06.004 · Cited by 196 · cited 1× · see citing works
“Different research groups have shown that VSMC senescence is present in atherosclerotic plaques and contributes to the pathogenesis of atherosclerosis.(21,32,53,54) Our observations confirm once more the dual role of VSMCs in atherosclerosis.”
BackgroundVascular smooth muscle cell motility: From migration to invasion.
Louis, S. F., & Zahradka, P. C. (2010) · PubMed Central · Cited by 193 · see citing works
Godin, D., Ivan, E., Johnson, C., Magid, R., & Galis, Z. S. (2000) · Circulation · doi:10.1161/01.cir.102.23.2861 · Cited by 192 · see citing works
mTOR inhibition: A promising strategy for stabilization of atherosclerotic plaques
Martinet, W., Loof, H. D., & Meyer, G. R. Y. D. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.01.040 · Cited by 191 · see citing works
Self-citationSchrijvers, D. M., Meyer, G. R. Y. D., & Martinet, W. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.224899 · Cited by 189 · see citing works
Self-citationUnsaturated lipid peroxidation-derived aldehydes activate autophagy in vascular smooth-muscle cells
Hill, B. G., Haberzettl, P., Ahmed, Y., Srivastava, S., & Bhatnagar, A. (2008) · Biochemical Journal · doi:10.1042/bj20071063 · Cited by 183 · see citing works
Takasaka, N., Araya, J., Hara, H., Ito, S., Kobayashi, K., Kurita, Y., Wakui, H., Yoshii, Y., Yumino, Y., Fujii, S., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1302341 · Cited by 180 · see citing works
Martinet, W., Knaapen, M., Meyer, G. R. Y. D., Herman, A. G., & Kockx, M. M. (2001) · Circulation Research · doi:10.1161/hh0701.088684 · Cited by 171 · see citing works
Self-citationAutophagy and senescence: A partnership in search of definition
Gewirtz, D. A. (2013) · Autophagy · doi:10.4161/auto.23922 · Cited by 166 · see citing works
Seimon, T. A., Wang, Y., Han, S., Senokuchi, T., Schrijvers, D. M., Kuriakose, G., Tall, A. R., & Tabas, I. A. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37262 · Cited by 155 · see citing works
Self-citationDing, Z., Wang, X., Schnackenberg, L. K., Khaidakov, M., Liu, S., Singla, S., Dai, Y., & Mehta, J. L. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.12.045 · Cited by 154 · see citing works
The Role of Oxidative Stress and Autophagy in Atherosclerosis
Perrotta, I. D., & Aquila, S. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/130315 · Cited by 147 · see citing works
Johnson, J. L. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu171 · Cited by 140 · see citing works
Mouse models of angiogenesis, arterial stenosis, atherosclerosis and hemostasis
Carmeliet, P. (1998) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00108-4 · Cited by 127 · see citing works
Martinet, W., de Bie, M., Schrijvers, D. M., Meyer, G. R. Y. D., Herman, A. G., & Kockx, M. M. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000146266.65820.a1 · Cited by 126 · see citing works
Self-citationAt concentrations that inhibit mTOR, resveratrol suppresses cellular senescence
Demidenko, Z. N., & Blagosklonny, M. V. (2009) · Cell Cycle · doi:10.4161/cc.8.12.8810 · Cited by 123 · see citing works
Guo, Z., Mitchell-Raymundo, F., Yang, H., Ikeno, Y., Nelson, J., Diaz, V., Richardson, A., & Reddick, R. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00008-8 · Cited by 121 · cited 1× · see citing works
“Caloric restriction for example, is a powerful tool to induce autophagy and has both life-span-prolonging and antiatherogenic properties in mice.(59) Also SIRT1 (sirtuin 1) deacetylase, an inducer of autophagy and a negative regulator of cellular aging, plays a protective role in atherosclerosis.”
Background7-Ketocholesterol Induces Autophagy in Vascular Smooth Muscle Cells through Nox4 and Atg4B
He, C., Zhu, H., Zhang, W., Okon, I. S., Wang, Q., Li, H., Le, Y.-Z., & Xie, Z. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.04.028 · Cited by 121 · see citing works
Implications of autophagy for vascular smooth muscle cell function and plasticity
Salabei, J. K., & Hill, B. G. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.08.003 · Cited by 107 · see citing works
Understanding the role of transforming growth factor-β1 in intimal thickening after vascular injury
KHAN, R., Agrotis, A., & Bobik, A. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.02.012 · Cited by 104 · see citing works
Reactive Oxygen Species and Death
Bennett, M. R. (2001) · Circulation Research · doi:10.1161/hh0701.089955 · Cited by 103 · see citing works
Cell senescence: Hypertrophic arrest beyond the restriction point
Blagosklonny, M. V. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20750 · Cited by 93 · see citing works
Löwik, C. W. G. M., Alblas, M. J., Vanderuit, M., Papapoulos, S. E., & Vanderpluijm, G. (1993) · Analytical Biochemistry · doi:10.1006/abio.1993.1442 · Cited by 91 · see citing works
TGF beta-induced growth inhibition in primary fibroblasts requires the retinoblastoma protein.
Herrera, R. E., Mäkelä, T. P., & Weinberg, R. A. (1996) · Molecular Biology of the Cell · doi:10.1091/mbc.7.9.1335 · Cited by 81 · see citing works
Autophagy plays a protective role in free cholesterol overload-induced death of smooth muscle cells
Xu, K., Yang, Y., Yan, M., Zhan, J., Fu, X., & Zheng, X. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m005702 · Cited by 77 · see citing works
Vindeløv, L. L., & Christensen, I. J. (1994) · Methods in cell biology · doi:10.1016/s0091-679x(08)61720-3 · Cited by 69 · see citing works
Yu, H., Stoneman, V. E. A., Clarke, M. C. H., Figg, N. L., Xin, H., Kotlikoff, M. I., Littlewood, T. D., & Bennett, M. R. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.218578 · Cited by 69 · see citing works
Emerging Roles of Mitochondria ROS in Atherosclerotic Lesions: Causation or Association?
Wang, Y., & Tabas, I. A. (2014) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.23929 · Cited by 68 · see citing works
Methods to Assess Autophagy In Situ—Transmission Electron Microscopy Versus Immunohistochemistry
Martinet, W., Timmermans, J., & Meyer, G. R. Y. D. (2014) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-801329-8.00005-2 · Cited by 64 · see citing works
Self-citationSasaki, M., Miyakoshi, M., Sato, Y., & Nakanuma, Y. (2011) · Liver International · doi:10.1111/j.1478-3231.2011.02656.x · Cited by 59 · see citing works
Debacq‐Chainiaux, F., Pascal, T. G., Boilan, E., Bastin, C., Bauwens, É., & Toussaint, O. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.02.001 · Cited by 52 · see citing works
The use of electron microscopy for the detection of autophagy in human atherosclerosis
Perrotta, I. D. (2013) · Micron · doi:10.1016/j.micron.2013.03.007 · Cited by 52 · see citing works
Everolimus for stent-based intracoronary applications.
Grube, E., & Buellesfeld, L. (2004) · PubMed · Cited by 29 · see citing works
Zhao, H. Q., Nikanorov, A., Virmani, R., & Schwartz, L. B. (2012) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2012.04.022 · Cited by 23 · see citing works
Aging increases p16INK4a expression in vascular smooth-muscle cells
Rodriguez-Menocal, L., Pham, S. M., Mateu, D., St-Pierre, M., Wei, Y., Pestana, I. A., Aı̈touche, A., & Vázquez-Padrón, R. I. (2009) · Bioscience Reports · doi:10.1042/bsr20080128 · Cited by 20 · see citing works
Flagged first, then by citations
1 of the 73 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Vascular smooth muscle cells in atherosclerosis
Basatemur, G. L., Jørgensen, H. F., Clarke, M. C. H., Bennett, M. R., & Mallat, Z. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0227-9 · Cited by 1,099 · see citing works
Vascular smooth muscle cell death, autophagy and senescence in atherosclerosis
Grootaert, M. O. J., Moulis, M., Roth, L., Martinet, W., Vindis, C., Bennett, M. R., & De Meyer, G. R. Y. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy007 · Cited by 606 · see citing works
Self-citationVascular Calcification—New Insights into Its Mechanism
Lee, S., Lee, I. K., & Jeon, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082685 · Cited by 451 · see citing works
Oxidative Stress-Mediated Atherosclerosis: Mechanisms and Therapies
Yang, X., Li, Y., Li, Y., Ren, X., Zhang, X., Hu, D., Gao, Y., Xing, Y., & Shang, H. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00600 · Cited by 410 · see citing works
Hong, S.-H., & Choi, K. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020494 · Cited by 390 · see citing works
Senescence mechanisms and targets in the heart
Chen, M. S., Lee, R. T., & Garbern, J. C. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab161 · Cited by 336 · see citing works
ROS signaling and ER stress in cardiovascular disease
Ochoa, C. D., Wu, R.-F., & Terada, L. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.03.002 · Cited by 286 · see citing works
Hallmarks of cardiovascular ageing
Abdellatif, M., Rainer, P. P., Sedej, S., & Kroemer, G. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-023-00881-3 · Cited by 285 · see citing works
Kitada, M., Ogura, Y., & Koya, D. (2016) · Aging · doi:10.18632/aging.101068 · Cited by 270 · see citing works
Vion, A.-C., Kheloufi, M., Hammoutène, A., Poisson, J., Lasselin, J., Devue, C., Pic, I., Dupont, N., Busse, J., Stark, K., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1702223114 · Cited by 229 · see citing works
Age-Associated Mitochondrial Dysfunction Accelerates Atherogenesis
Tyrrell, D. J., Blin, M. G., Song, J., Wood, S. C., Zhang, M., Beard, D. A., & Goldstein, D. R. (2019) · Circulation Research · doi:10.1161/circresaha.119.315644 · Cited by 228 · see citing works
Macrophage Death as a Pharmacological Target in Atherosclerosis
Martinet, W., Coornaert, I., Puylaert, P., & Meyer, G. R. Y. D. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00306 · Cited by 227 · see citing works
Self-citationVascular Smooth Muscle Cells in Aortic Aneurysm: From Genetics to Mechanisms
Lu, H., Du, W., Ren, L., Hamblin, M. H., Becker, R. C., Chen, Y. E., & Fan, Y. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.121.023601 · Cited by 218 · see citing works
Emerging roles of ATG7 in human health and disease
Collier, J. J., Suomi, F., Oláhová, M., McWilliams, T. G., & Taylor, R. W. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202114824 · Cited by 191 · see citing works
Cao, H., Jia, Q., Li, Y., Chen, C., Xing, S., & Shen, D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20236093 · Cited by 189 · see citing works
SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence
Salazar, G., Cullen, A. E., Huang, J., Zhao, Y., Serino, A., Hilenski, L. L., Patrushev, N. A., Forouzandeh, F., & Hwang, H. S. (2019) · Autophagy · doi:10.1080/15548627.2019.1659612 · Cited by 183 · see citing works
Vascular Smooth Muscle Cell Plasticity and Autophagy in Dissecting Aortic Aneurysms
Clément, M., Chappell, J., Raffort, J., Lareyre, F., Vandestienne, M., Taylor, A. L., Finigan, A., Harrison, J., Bennett, M. R., Bruneval, P., et al. (2019) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.118.311727 · Cited by 184 · see citing works
Reactive Oxygen Species Generation and Atherosclerosis
Nowak, W. N., Deng, J., Ruan, X. Z., & Xu, Q. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.309228 · Cited by 179 · see citing works
Autophagy, Pyroptosis, and Ferroptosis: New Regulatory Mechanisms for Atherosclerosis
Lin, L., Zhang, M.-X., Zhang, L., Zhang, D., Li, C., & Li, Y. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.809955 · Cited by 165 · see citing works
Apoptosis, autophagy and atherosclerosis: Relationships and the role of Hsp27
Shan, R., Liu, N., Yan, Y., & Liu, B. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105169 · Cited by 165 · see citing works
Guo, F., Wu, Q., Li, P., Zheng, L., Ye, S., Dai, X.-Y., Kang, C., Lu, J., Xu, B., Xu, Y., et al. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-018-0235-z · Cited by 160 · see citing works
Vascular smooth muscle cell senescence and age-related diseases: State of the art
Chen, C., Li, D., Jiang, Y., Tong, J., Fu, H., Wu, Y.-H., & Shen, F. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.08.015 · Cited by 159 · see citing works
Defective autophagy in vascular smooth muscle cells enhances cell death and atherosclerosis
Osonoi, Y., Mita, T., Azuma, K., Nakajima, K., Masuyama, A., Goto, H., Nishida, Y., Miyatsuka, T., Fujitani, Y., Koike, M., et al. (2018) · Autophagy · doi:10.1080/15548627.2018.1501132 · Cited by 149 · see citing works
Autophagy in health and disease: focus on the cardiovascular system
Mialet‐Perez, J., & Vindis, C. (2017) · Essays in Biochemistry · doi:10.1042/ebc20170022 · Cited by 149 · see citing works
Defective autophagy in atherosclerosis: to die or to senesce?
Grootaert, M. O. J., Roth, L., Schrijvers, D. M., De Meyer, G. R. Y., & Martinet, W. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/7687083 · Cited by 147 · see citing works
Self-citationCellular senescence links aging and diabetes in cardiovascular disease
Shakeri, H., Lemmens, K., Gevaert, A. B., De Meyer, G. R. Y., & Segers, V. F. M. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00287.2018 · Cited by 134 · see citing works
Zhang, X., Ramírez, C. M., Aryal, B., Madrigal‐Matute, J., Liu, X., Díaz, A., Torrecilla-Parra, M., Suárez, Y., Cuervo, A. M., Sessa, W. C., et al. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.314291 · Cited by 127 · see citing works
Swiader, A., Nahapetyan, H., Faccini, J., D’Angelo, R., Mucher, E., Elbaz, M., Boya, P., & Vindis, C. (2016) · Oncotarget · doi:10.18632/oncotarget.8936 · Cited by 125 · see citing works
The role of autophagy in cardiovascular pathology
Gatica, D., Chiong, M., Lavandero, S., & Klionsky, D. J. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab158 · Cited by 120 · see citing works
Peng, S., Xu, L., Che, X., Xiao, Q., Pu, J., Shao, Q., & He, B. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00438 · Cited by 107 · see citing works
Mitophagy in Cardiovascular Diseases
Morciano, G., Patergnani, S., Bonora, M., Pedriali, G., Tarocco, A., Bouhamida, E., Marchi, S., Ancora, G., Anania, G., Wieckowski, M. R., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9030892 · Cited by 106 · see citing works
Protective role of chaperone-mediated autophagy against atherosclerosis
Madrigal‐Matute, J., de Bruijn, J., van Kuijk, K., Riascos‐Bernal, D. F., Díaz, A., Tasset, I., Martín‐Segura, A., Gijbels, M. J., Sander, B., Kaushik, S., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2121133119 · Cited by 105 · see citing works
Jiang, Y., Kou, J., Han, X. B., Li, X., Zhong, Z., Liu, Z., Zheng, Y., Tian, Y., & Yang, L. M. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/8519169 · Cited by 99 · see citing works
Michiels, C. F., Kurdi, A., Timmermans, J., Meyer, G. R. Y. D., & Martinet, W. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.07.899 · Cited by 100 · see citing works
Self-citationMitochondrial Dynamics and Mitophagy in Cardiometabolic Disease
Lin, J., Duan, J., Wang, Q., Xu, S., Zhou, S., & Yao, K. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.917135 · Cited by 101 · see citing works
Song, J., Zhang, Y., Frieler, R. A., Andren, A. C., Wood, S. C., Tyrrell, D. J., Sajjakulnukit, P., Deng, J. C., Lyssiotis, C. A., Mortensen, R. M., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci173034 · Cited by 96 · see citing works
DNA Damage: A Main Determinant of Vascular Aging
Bautista‐Niño, P. K., Portilla-Fernández, E., Vaughan, D. E., Danser, A. H. J., & Roks, A. J. M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17050748 · Cited by 95 · see citing works
Role of autophagy in atherosclerosis: foe or friend?
Hassanpour, M., Rahbarghazi, R., Nouri, M., Aghamohammadzadeh, N., Safaei, N., & Ahmadi, M. (2019) · Journal of Inflammation · doi:10.1186/s12950-019-0212-4 · Cited by 94 · see citing works
Metformin suppresses vascular smooth muscle cell senescence by promoting autophagic flux
Tai, S., Sun, J., Zhou, Y., Zhu, Z., He, Y., Chen, M., Yang, H., Xiao, Y., Tu, T., Tang, L., et al. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2021.12.009 · Cited by 98 · see citing works
Autophagy as a novel therapeutic target in vascular calcification
Phadwal, K., Feng, D., Zhu, D., & MacRae, V. E. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107430 · Cited by 90 · see citing works
The roles of autophagy in vascular smooth muscle cells
Tai, S., Hu, X., Peng, D., Zhou, S., & Zheng, X. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.02.128 · Cited by 88 · see citing works
Wu, H., Song, A., Hu, W., & Dai, M. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00948 · Cited by 88 · see citing works
Pawłowska, E., Szczepańska, J., Wiśniewski, K., Tokarz, P., Jaskólski, D. J., & Błasiak, J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041245 · Cited by 84 · see citing works
Targeting senescent cells to attenuate cardiovascular disease progression
Song, P., Zhao, Q., & Zou, M. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101072 · Cited by 76 · see citing works
Xu, J., Kitada, M., Ogura, Y., & Koya, D. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.641852 · Cited by 72 · see citing works
Lázaro, I., Lopez‐Sanz, L., Bernal, S., Oguiza, A., Recio, C., Melgar, A., Jiménez-Castilla, L., Egido, J., Madrigal‐Matute, J., & Gómez‐Guerrero, C. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00819 · Cited by 74 · see citing works
Uryga, A. K., Grootaert, M. O. J., Garrido, A. M., Oc, S., Foote, K., Chappell, J., Finigan, A., Rossiello, F., d’Adda di Fagagna, F., Aravani, D., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02123-z · Cited by 73 · see citing works
Self-citationLuo, Z., Xu, W., Ma, S., Qiao, H., Gao, L., Zhang, R., Yang, B. Y., Qiu, Y. F., Chen, J., Zhang, M., et al. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/3018190 · Cited by 72 · see citing works
Nakagawa, K., & Nakashima, Y. (2018) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2018.03.039 · Cited by 70 · see citing works
Yang, J., Yu, J., Li, D., Yu, S., Jingbin, K., Wang, L., Wang, Y., Qiu, Y., Gao, X., Zhang, J., et al. (2016) · Autophagy · doi:10.1080/15548627.2016.1245261 · Cited by 69 · see citing works
Nahapetyan, H., Moulis, M., Grousset, E., Faccini, J., Grazide, M.-H., Mucher, E., Elbaz, M., Martinet, W., & Vindis, C. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1400-0 · Cited by 68 · see citing works
Self-citationHe, L., Chen, Q., Wang, L., Pu, Y., Huang, J., Cheng, C. K., Luo, J., Kang, L., Lin, X., Li, X., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103229 · Cited by 67 · see citing works
Role of AMPK in atherosclerosis via autophagy regulation
Ou, H.-X., Liu, C., Feng, W., Xiao, X., Tang, S., & Mo, Z. (2018) · Science China Life Sciences · doi:10.1007/s11427-017-9240-2 · Cited by 62 · see citing works
Ma, C., Wu, H., Yang, G., Xiang, J., Feng, K., Zhang, J., Hua, Y., Kang, L., Fan, G., & Yang, S. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15720 · Cited by 59 · see citing works
Lysosome (Dys)function in Atherosclerosis—A Big Weight on the Shoulders of a Small Organelle
Marques, A. R. A., Ramos, C., Machado-Oliveira, G., & Vieira, O. V. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.658995 · Cited by 52 · see citing works
Galindo, C. L., Khan, S. R., Zhang, X., Yeh, Y., Liu, Z., & Razani, B. (2023) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2023.2288272 · Cited by 56 · see citing works
Role of Autophagy in Proteostasis: Friend and Foe in Cardiac Diseases
Li, J., Zhang, D., Wiersma, M., & Brundel, B. J. J. M. (2018) · Cells · doi:10.3390/cells7120279 · Cited by 54 · see citing works
The Long Non-coding Road to Atherosclerosis
Josefs, T., & Boon, R. A. (2020) · Current Atherosclerosis Reports · doi:10.1007/s11883-020-00872-6 · Cited by 52 · see citing works
Quercetin has a protective effect on atherosclerosis via enhancement of autophagy in ApoE‑/‑ mice
Cao, H., Jia, Q., Shen, D., Li, Y., Chen, C., & Xing, S. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.7851 · Cited by 51 · see citing works
Lysosomes in the immunometabolic reprogramming of immune cells in atherosclerosis
Bonacina, F., Zhang, X., Manel, N., Yvan‐Charvet, L., Razani, B., & Norata, G. D. (2024) · Nature Reviews Cardiology · doi:10.1038/s41569-024-01072-4 · Cited by 50 · see citing works
Cell senescence in cardiometabolic diseases
Grootaert, M. O. J. (2024) · npj Aging · doi:10.1038/s41514-024-00170-4 · Cited by 54 · see citing works
Self-citationFang, Z., Zhang, S., Luo, H., Jiang, D., Huo, B., Zhong, X., Feng, X., Cheng, W., Chen, Y., Feng, G., et al. (2022) · Cell Proliferation · doi:10.1111/cpr.13386 · Cited by 46 · see citing works
García-Miguel, M., Riquelme, J. A., Norambuena‐Soto, I., Morales, P. E., Sanhueza‐Olivares, F., Núñez-Soto, C., Mondaca‐Ruff, D., Cancino-Arenas, N., Martín, A. S., & Chiong, M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0197210 · Cited by 46 · see citing works
Autophagy in Metabolic Age-Related Human Diseases
Moulis, M., & Vindis, C. (2018) · Cells · doi:10.3390/cells7100149 · Cited by 46 · see citing works
Clement, M., Raffort, J., Lareyre, F., Tsiantoulas, D., Newland, S., Lu, Y., Masters, L., Harrison, J., Saveljeva, S., Ma, M. K. L., et al. (2019) · Circulation Research · doi:10.1161/circresaha.119.315248 · Cited by 44 · see citing works
Smooth muscle-specific HuR knockout induces defective autophagy and atherosclerosis
Liu, S., Jiang, X., Cui, X., Wang, J., Liu, S., Li, H., Yang, J., Zhang, C., & Zhang, W. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03671-2 · Cited by 43 · see citing works
You, G., Long, X., Song, F., Huang, J., Tian, M., Xiao, Y., Deng, S., & Wu, Q. (2020) · Drug Design Development and Therapy · doi:10.2147/dddt.s233932 · Cited by 44 · see citing works
The Role of SGLT2 Inhibitors in Vascular Aging
Liu, L., Ni, Y., Zhan, J., & Liu, Y. (2021) · Aging and Disease · doi:10.14336/ad.2020.1229 · Cited by 44 · see citing works
A new perspective on intervertebral disc calcification—from bench to bedside
Novais, E. J., Narayanan, R., Canseco, J. A., van de Wetering, K., Kepler, C. K., Hilibrand, A. S., Vaccaro, A. R., & Risbud, M. V. (2024) · Bone Research · doi:10.1038/s41413-023-00307-3 · Cited by 43 · see citing works
Substrate stiffness differentially impacts autophagy of endothelial cells and smooth muscle cells
Hu, M., Jia, F., Huang, W., Xu, L. L., Hu, D., Wang, J., Ren, K., Fu, G., Wang, Y., & Ji, J. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.10.013 · Cited by 44 · see citing works
Ramadan, A., Singh, K. K., Quan, A., Plant, P. J., Al-Omran, M. A., Teoh, H., & Verma, S. (2017) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2017.08.086 · Cited by 41 · see citing works
Wang, Y., Li, X., Chen, J., McConnell, B. K., Chen, L., Li, P., Chen, Y., & Zhang, Y. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1931-4 · Cited by 41 · see citing works
Atherosclerosis and Coenzyme Q10
Suarez-Rivero, J. M., Pastor‐Maldonado, C. J., de la Mata, M., Paz, M. V., Povea-Cabello, S., Álvarez-Córdoba, M., Villalón-García, I., Suárez-Carrillo, A., Talaverón-Rey, M., Munuera-Cabeza, M., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205195 · Cited by 41 · see citing works
Caspase‐3 Deletion Promotes Necrosis in Atherosclerotic Plaques of ApoE Knockout Mice
Grootaert, M. O. J., Schrijvers, D. M., Hermans, M., Hoof, V. O. V., Meyer, G. R. Y. D., & Martinet, W. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3087469 · Cited by 39 · see citing works
Self-citationWang, X., Li, D., Chen, H., Wei, X., & Xu, X. (2019) · Medical Science Monitor · doi:10.12659/msm.915681 · Cited by 39 · see citing works
Saha, S., Profumo, E., Togna, A. R., Riganò, R., Saso, L., & Buttari, B. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/1232816 · Cited by 39 · see citing works
The putative role of autophagy in the pathogenesis of abdominal aortic aneurysms
Ramadan, A., Al-Omran, M. A., & Verma, S. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.01.017 · Cited by 38 · see citing works
Profumo, E., Maggi, E., Arese, M., Cristofano, C. D., Salvati, B., Saso, L., Businaro, R., & Buttari, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113009 · Cited by 37 · see citing works
Liu, Q., Wang, Y., & Gu, H. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2020.10.025 · Cited by 37 · see citing works
Programmed Cell Death: Complex Regulatory Networks in Cardiovascular Disease
Zhou, L., Sun, J., Gu, L., Wang, S., Yang, T., Wei, T., Shan, T., Wang, H., & Wang, L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.794879 · Cited by 37 · see citing works
Chronic Stress A Potential Suspect Zero of Atherosclerosis: A Systematic Review
Meng, L., Zhang, Y.-M., Luo, Y., Gong, T., & Liu, D. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.738654 · Cited by 37 · see citing works
Ho‐Tin‐Noé, B., Vo, S., Bayles, R., Ferrière, S., Ladjal, H., Toumi, S., Deschildre, C., Ollivier, V., & Michel, J. (2016) · The Journal of Pathology · doi:10.1002/path.4873 · Cited by 36 · see citing works
Komaravolu, R. K., Waltmann, M. D., Konaniah, E. S., Jaeschke, A., & Hui, D. Y. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.313194 · Cited by 38 · see citing works
Chen, Y., Su, X., Qin, Q., Yu, Y., Jia, M., Zhang, H., Li, H., & Pei, L. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109758 · Cited by 36 · see citing works
Jarad, S., Gill, G. S., Amadi, P. U., Gu, H.-M., & Zhang, D. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107833 · Cited by 40 · see citing works
Perpetual change: autophagy, the endothelium, and response to vascular injury
Sachdev, U., & Lotze, M. T. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.3ru1116-484rr · Cited by 35 · see citing works
Small-Vessel Vasculopathy Due to Aberrant Autophagy in LAMP-2 Deficiency
Nguyen, H. T., Noguchi, S., Sugie, K., Matsuo, Y., Nguyen, C. T. H., Koito, H., Shiojima, I., Nishino, I., & Tsukaguchi, H. (2018) · Scientific Reports · doi:10.1038/s41598-018-21602-8 · Cited by 35 · see citing works
Metabolic Alterations in Cardiopulmonary Vascular Dysfunction
Smolders, V. F. E. D., Zodda, E., Quax, P. H. A., Carini, M., Barberà, J. A., Thomson, T. M., Tura-Ceide, O., & Cascante, M. (2019) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2018.00120 · Cited by 36 · see citing works
Celastrol ameliorates vascular neointimal hyperplasia through Wnt5a-involved autophagy
Shi, Y., Liu, L., Deng, C., Zhao, T., Shi, Z., Yan, J., Gong, Y.-Z., Liao, D., & Li, Q. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.58715 · Cited by 35 · see citing works
Gkaliagkousi, Ε., Lazaridis, A. A., Doğan, S., Fraenkel, E., Tuna, B. G., Mozos, I. M., VUKIĆEVIĆ, M., Yalçın, Ö., & Gopčević, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158672 · Cited by 35 · see citing works
Ma, M., Li, F., Li, W., Zhao, H., Jiang, M., Yu, Y., Dong, Y., Zhang, Y., Li, P., Bu, W., et al. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15949 · Cited by 35 · see citing works
Xu, X.-J., Zhao, W., Feng, S., Sun, C., Chen, Q., Ni, B., & Hu, H. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7533 · Cited by 34 · see citing works
Li, D., Chen, A., Lan, T., Zou, Y., Zhao, L., Yang, P., Qu, H., Li, W., Varghese, Z., Moorhead, J. F., et al. (2018) · The FASEB Journal · doi:10.1096/fj.201800975rrr · Cited by 34 · see citing works
Pharmacological modulation of vascular ageing: A review from VascAgeNet
Roth, L., Doğan, S., Tuna, B. G., Arányi, T., Benı́tez, S., Borrell-Pagés, M., Bozaykut, P., Meyer, G. R. Y. D., Duca, L., Durmuş, N., et al. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102122 · Cited by 36 · see citing works
Self-citationZhang, P., Guan, Y., Chen, J., Li, X., McConnell, B. K., Zhou, W. J., Boini, K. M., & Zhang, Y. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-1197-2 · Cited by 33 · see citing works
Xiao, Q., Che, X., Cai, B., Tao, Z., Zhang, H., Shao, Q., & Pu, J. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14715 · Cited by 33 · see citing works
Ouyang, C., Mu, J., Lu, Q., Li, J., Zhu, H., Wang, Q., Zou, M., & Xie, Z. (2019) · Autophagy · doi:10.1080/15548627.2019.1707488 · Cited by 33 · see citing works
Lin, J., Chen, R., Yang, L., Gong, M., Du, M.-Y., Mu, S.-Q., Jiang, Z.-A., Li, H., Yang, Y., Wang, X., et al. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.07.010 · Cited by 31 · see citing works
Ouyang, C., Li, J., Zheng, X., Mu, J., Torres, G., Wang, Q., Zou, M., & Xie, Z. (2021) · Autophagy · doi:10.1080/15548627.2021.1911018 · Cited by 32 · see citing works
Nakagawa, K., Tanaka, M., Hahm, T., Nguyen, H.-N., Matsui, T., Chen, Y.-X., & Nakashima, Y. (2021) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.121.316154 · Cited by 32 · see citing works
- Authors
- Grootaert, M. O., da Costa Martins, P. A., Bitsch, N., Pintelon, I., De Meyer, G. R., Martinet, W., & Schrijvers, D. M.
- Affiliations
- University of Antwerp (BE)
- Department of Cardiology; Cardiovascular Research Institute Maastricht; Maastricht, The Netherlands
- Maastricht University (NL)
- Laboratory of Physiopharmacology; University of Antwerp; Antwerp, Belgium
- Corresponding author
- Schrijvers, Dorien M
- Venue
- Autophagy
- Publisher
- Informa UK Limited
- Published
- 2015-11-02
- Volume
- 11
- Issue
- 11
- Pages
- 2014-2032
- ISSN
- 1554-8627 (ISSN-L)
- 1554-8635
- PMC
- PMC4824610
- OpenAlex
- W2200751652
- Cited by
- 267
- References
- 73
- Citations by year
- 2026: 8 · 2025: 20 · 2024: 22 · 2023: 28 · 2022: 28 · 2021: 35 · 2020: 30 · 2019: 31 · 2018: 33 · 2017: 19 · 2016: 13
- FWCI
- 17.00
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Autophagy (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Digital Access to Libraries (submittedVersion, other-oa)
- Funders
- Fonds Wetenschappelijk Onderzoek (G044312N)
- Vlaamse regering
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Keywords
- vascular smooth muscle cells, cellular senescence, neointima formation, atherosclerosis, ATG7, p62, stress-induced premature senescence, Nrf2, oxidative stress resistance, GLB1, MMP-9, CXCL12, collagen deposition
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review