The DOI matches its Crossref record; 104 of the 104 references it cites were found in a registry or an index.
Estrogen, natriuretic peptides and the renin-angiotensin system.
Abstract
There are significant gender-specific differences in the incidence of hypertension and the clinical outcome of cardiovascular disease between premenopausal women and age-matched men, suggesting that sex hormones such as estrogen (E) might be responsible for the observed cardioprotective effects. This cardioprotective action of E is thought to involve lipoproteins. However, the effect of E on the lipid profile accounts for about 50% of the reduction in cardiovascular disease, indicating that there might be other mechanisms by which E exerts its cardioprotective effects. At present, the underlying mechanism of E action is poorly understood. In this review, the interplay between E, the natriuretic peptides (NP) and the renin-angiotensin system (RAS) is examined. It is hypothesized that E might, through endocrine and/or paracrine action, modulate cardiac NP in females by affecting the RAS either directly or indirectly.
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“Conversely, others have shown that estradiol administration can activate the RAAS by enhancing angiotensinogen synthesis, inhibiting angiotensin-converting enzyme activity, and augmenting plasma and tissue levels of renin (15).”
From Sex Hormone Effects on Body Fluid Regulation (2008) · cites this paper as [15]
Citations
Cites
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Metadata
- Authors
- Kuroski de Bold, M.
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-03-01
- Volume
- 41
- Issue
- 3
- Pages
- 524-531
- ISSN
- 0008-6363 (ISSN-L)
- OpenAlex
- W2161506816
- Cited by
- 122
- References
- 104
- Citations by year
- 2026: 2 · 2024: 6 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 3
- FWCI
- 1.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cardiovascular Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Keywords
- estrogen, natriuretic peptides, renin-angiotensin system, sex hormones, hypertension in women, cardiovascular disease, cardioprotection, premenopausal women, lipid profile, paracrine signaling
- MeSH terms
- Animals, Cardiovascular Diseases, Estrogens, Female, Homeostasis, Humans, Hypertension, Male, Middle Aged, Myocardium, Atrial Natriuretic Factor, Receptors, Estrogen, Renin-Angiotensin System, Testosterone, Natriuretic Peptide, Brain, Rats
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