The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Ionic mechanisms of electrical remodeling in human atrial fibrillation
Abstract
OBJECTIVES: Atrial fibrillation (AF) is associated with a decrease in atrial ERP and ERP adaptation to rate as well as changes in atrial conduction velocity. The cellular changes in repolarization and the underlying ionic mechanisms in human AF are only poorly understood. METHODS: Action potentials (AP) and ionic currents were studied with the patch clamp technique in single atrial myocytes from patients in chronic AF and compared to those from patients in stable sinus rhythm (SR). RESULTS: The presence of AF was associated with a marked shortening of the AP duration and a decreased rate response of atrial repolarization. L-type calcium current (ICa,L) and the transient outward current (Ito) were both reduced about 70% in AF, whereas an increased steady-state outward current was detectable at test potentials between -30 and 0 mV. The inward rectifier potassium current (IKI) and the acetylcholine-activated potassium current (IKACh) were increased in AF at hyperpolarizing potentials. Voltage-dependent inactivation of the fast sodium current (INa) was shifted to more positive voltages in AF. CONCLUSIONS: AF in humans leads to important changes in atrial potassium and calcium currents that likely contribute to the decrease in APD and APD rate adaptation. These changes contribute to electrical remodeling in AF and are therefore important factors for the perpetuation of the arrhythmia.
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Cites
Atrial Fibrillation Begets Atrial Fibrillation: A Study in Awake Chronically Instrumented Goats
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Epidemiologic Features of Chronic Atrial Fibrillation: The Framingham Study
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Ionic Remodeling Underlying Action Potential Changes in a Canine Model of Atrial Fibrillation
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Outward K + Current Densities and Kv1.5 Expression Are Reduced in Chronic Human Atrial Fibrillation
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Self-citationEffect of Atrial Fibrillation on Atrial Refractoriness in Humans
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Cited by
New ideas about atrial fibrillation 50 years on
Nattel, S. (2002) · Nature · doi:10.1038/415219a · Cited by 1,481
Pathophysiological mechanisms of atrial fibrillation: a translational appraisal
Schotten, U., Verheule, S., Kirchhof, P., & Goette, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00031.2009 · Cited by 1,273
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Human Atrial Action Potential and Ca 2+ Model: Sinus Rhythm and Chronic Atrial Fibrillation
Grandi, E., Pandit, S. V., Voigt, N., Workman, A. J., Dobrev, D., Jalife, J., & Bers, D. M. (2011) · Circulation Research · doi:10.1161/circresaha.111.253955 · Cited by 365
Cardiac adrenergic control and atrial fibrillation
Workman, A. J. (2010) · Naunyn-Schmiedeberg's Archives of Pharmacology · doi:10.1007/s00210-009-0474-0 · Cited by 143
“…AF in patients was associated with a decreased atrial ERP and RA conduction velocity, increased ERP dispersion (Kojodjojo et al. 2007) and decreased atrial isolated tissue or cellular ERP (Workman et al. 2001) or APD 90 (Bosch et al. 1999; Workman et al. 2001; Wettwer et al. 2004; Pau et al. 2007).”
Metadata
- Authors
- Bosch, R.
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-10
- Volume
- 44
- Issue
- 1
- Pages
- 121-131
- ISSN
- 0008-6363 (ISSN-L)
- OpenAlex
- W2063344460
- Cited by
- 580
- References
- 30
- FWCI
- 13.58
- Type
- journal article
- Language
- en
- Open access
- closed
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