New ideas about atrial fibrillation 50 years on

Nattel, Stanley

doi:10.1038/415219a

Cited by 1,481Atrial Fibrillation Management and OutcomesCardiac electrophysiology and arrhythmiasCardiac Arrhythmias and Treatments

New ideas about atrial fibrillation 50 years on

Nattel, Stanley·2002·Nature

DOI 10.1038/415219a

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Abstract

Atrial fibrillation is a condition in which control of heart rhythm is taken away from the normal sinus node pacemaker by rapid activity in different areas within the upper chambers (atria) of the heart. This results in rapid and irregular atrial activity and, instead of contracting, the atria only quiver. It is the most common cardiac rhythm disturbance and contributes substantially to cardiac morbidity and mortality. For over 50 years, the prevailing model of atrial fibrillation involved multiple simultaneous re-entrant waves, but in light of new discoveries this hypothesis is now undergoing re-evaluation.

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Although the pathophysiology of AF has been investigated extensively, our understanding of the differences between male and female cardiac anatomy and electrical mechanisms is insufficient.
“Although the pathophysiology of AF has been investigated extensively through the years,170 our understanding of the differences between male and female cardiac anatomy and electrical mechanisms, which might contribute to difference in risks and prognosis of AF by sex, is insufficient.”
From Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis (2016) · cites this paper as [170]

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Authors: Nattel, S.
Affiliations: Montreal Heart Institute (CA)
Corresponding author: Nattel, Stanley
ORCID: Nattel, Stanley
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2002-01
Volume: 415
Issue: 6868
Pages: 219-226
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/415219a
OpenAlex: W2062206620
Cited by: 1,481
References: 80
Citations by year: 2026: 29 · 2025: 21 · 2024: 39 · 2023: 41 · 2022: 40 · 2021: 53 · 2020: 42 · 2019: 48 · 2018: 52 · 2017: 57 · 2016: 57 · 2015: 60 · 2014: 100 · 2013: 89 · 2012: 83
FWCI: 8.70
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
Keywords: atrial fibrillation, cardiac arrhythmias, atrial fibrillation mechanisms, atrial electrical activity, cardiac rhythm control
MeSH terms: Animals, Atrial Fibrillation, Electrophysiology, Forecasting, Humans, Models, Biological, Pulmonary Veins, Sinoatrial Node

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