Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: The fiamingham Study
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Chronic atrial fibrillation (AF) as a precursor of stroke was assessed over 24 years of follow-up of the general population sample at Framingham, Massachusetts. Persons with chronic established AF, with or without rheumatic heart disease (RHD), are at greatly increased risk of stroke, and the stroke is probably due to embolism. Chronic AF in the absence of RHD is associated with more than a fivefold increase in stroke indicence, while AF with RHD has a 17-fold increase. Stroke occurrence increased as duration of AF increased, with no evidence of a particularly vulnerable period. Chronic idiopathic AF is an important precursor of cerebral embolism. Controlled trials of anticoagulants or antiarrhythmic agents in persons with chronic AF may demonstrate if strokes can be prevented in this highly susceptible group.
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Benjamin et al. showed that the population attributable risk for developing atrial fibrillation was highest for hypertension, despite other risk factors having higher relative risks.
“For instance, Benjamin and colleagues showed that the PAR for developing atrial fibrillation was highest for hypertension, despite the fact that other risk factors were associated with higher relative risks.80”
From The Framingham Heart Study and the epidemiology of cardiovascular disease: a historical perspective (2014) · cites this paper as [80]
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- Authors
- Wolf, P. A., Dawber, T. R., Thomas, H. E., & Kannel, W. B.
- Affiliations
- Boston University (US)
- ORCID
- Wolf, Philip A.
- Venue
- Neurology
- Published
- 1978-10
- Volume
- 28
- Issue
- 10
- Pages
- 973-973
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2161283927
- Semantic Scholar
- 36de11b13c1674c0a05e028d89d7b881504127cb
- Cited by
- 1,526
- References
- 12
- Citations by year
- 2026: 15 · 2025: 35 · 2024: 36 · 2023: 49 · 2022: 30 · 2021: 73 · 2020: 53 · 2019: 34 · 2018: 38 · 2017: 44 · 2016: 44 · 2015: 49 · 2014: 43 · 2013: 47 · 2012: 45
- FWCI
- 4.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cardiovascular and Diving-Related Complications
- Keywords
- chronic atrial fibrillation, stroke risk, cerebral embolism, rheumatic heart disease, idiopathic atrial fibrillation, atrial fibrillation duration, stroke incidence, anticoagulation, antiarrhythmic drugs, Framingham Heart Study
- MeSH terms
- Adult, Atrial Fibrillation, Cerebrovascular Disorders, Chronic Disease, Embolism, Female, Follow-Up Studies, Humans, Male, Massachusetts, Middle Aged, Rheumatic Heart Disease
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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