Skin absorption and human risk assessment
Abstract
A common practice is to assume that percutaneous absorption does not significantly contribute to total bioavailability and therefore, absorption through other routes is more important to human risk assessment. The skin can represent a significant barrier to absorption, but some substances are absorbed to a significant extent. Since there is a potential for percutaneous penetration that is not consistent between species or substances, the assessment of the potential contribution of total body burden from dermal exposures should be considered. This review briefly discusses some theories, practices, and factors that affect percutaneous absorption with an emphasis on how percutaneous absorption evaluations apply to human risk assessment.
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Absorption of toxicants in the skin depends on several factors, including the integrity and hydration state of the stratum corneum, temperature, solubility in the carrier, and molecular weight.
“Absorption of toxicants in the skin depends on several factors, including the integrity and hydration state of the stratum corneum, temperature, solubility in the carrier, and molecular weight49.”
From Morphological characteristics and notes of the skin in preclinical toxicity assessment (2023) · cites this paper as [49]
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- Authors
- Poet, T. S., & McDougal, J. N.
- Affiliations
- Pacific Northwest National Laboratory (US)
- Wright State University (US)
- Corresponding author
- Poet, Torka S.
- Venue
- Chemico-Biological Interactions
- Publisher
- Elsevier BV
- Published
- 2002-04
- Volume
- 140
- Issue
- 1
- Pages
- 19-34
- ISSN
- 0009-2797 (ISSN-L)
- OpenAlex
- W2105764153
- Cited by
- 104
- References
- 0
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 6 · 2023: 3 · 2022: 5 · 2021: 1 · 2020: 9 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 4 · 2014: 7 · 2013: 6 · 2012: 8
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemico-Biological Interactions (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Pesticide Exposure and Toxicity
- Keywords
- percutaneous absorption, dermal exposure, human risk assessment, skin permeability, bioavailability, interspecies variability, body burden
- MeSH terms
- Animals, Biological Availability, Humans, Skin, Skin Absorption, Xenobiotics, Risk Assessment, Models, Animal, Mice, In Vitro Techniques
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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