The DOI matches its Crossref record; 144 of the 153 references it cites were found in a registry or an index.
Ligand binding and activation of the Ah receptor
Abstract
The Ah receptor (AhR) is a ligand-dependent transcription factor that can be activated by structurally diverse synthetic and naturally-occurring chemicals. Although a significant amount of information is available with respect to the planar aromatic hydrocarbon AhR ligands, the actual spectrum of chemicals that can bind to and activate the AhR is only now being elucidated. In addition, the lack of information regarding the actual three-dimensional structure of the AhR ligand binding domain (LBD) has hindered detailed analysis of the molecular mechanisms by which these ligands bind to and active AhR signal transduction. In this review we describe the current state of knowledge with respect to naturally occurring AhR ligands and present and discuss the first theoretical model of the AhR LBD based on crystal structures of homologous PAS family members.
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“While the AhR can bind and be activated by a large number of structurally diverse chemicals (4-6), the highest affinity ligands include halogenated aromatic hydrocarbons (HAHs), such as 2,3,7,8tetrachlorodibenzop -dioxin (TCDD, dioxin), and polycyclic aromatic hydrocarbons (PAHs), both widespread classes of environmental contaminants (4,7).”
From Structural and Functional Characterization of the Aryl Hydrocarbon Receptor Ligand Binding Domain by Homology Modeling and Mutational Analysis (2007) · cites this paper as [6]
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Cites
Berman, H. M. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.1.235 · Cited by 40,196
Poland, A., & Knutson, J. C. (1982) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.22.040182.002505 · Cited by 2,515
Safe, S. (1990) · Critical Reviews in Toxicology · doi:10.3109/10408449009089873 · Cited by 1,871
Safe, S. H. (1994) · Critical Reviews in Toxicology · doi:10.3109/10408449409049308 · Cited by 1,760
The Aryl Hydrocarbon Receptor Complex
Hankinson, O. (1995) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.35.040195.001515 · Cited by 1,649 · cited 2×
“Formation of the AhR:Arnt heterodimer converts the complex into its high affinity DNA binding form [1,19] and binding of the complex to its specific DNA recognition site, the dioxin responsive element (DRE), upstream of the CYP1A1 gene leads to chromatin and nucleosome disruption, increased promoter accessibility and…”
BackgroundPAS Domains: Internal Sensors of Oxygen, Redox Potential, and Light
Taylor, B. L., & Zhulin, I. B. (1999) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.63.2.479-506.1999 · Cited by 1,632
INDUCTION OF CYTOCHROME P4501A1
Whitlock, J. P. (1999) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.39.1.103 · Cited by 1,136
Immune System Impairment and Hepatic Fibrosis in Mice Lacking the Dioxin-Binding Ah Receptor
Fernandez-Salguero, P., Pineau, T., Hilbert, D. M., McPhail, T., Lee, S. S. T., Kimura, S., Nebert, D. W., Rudikoff, S., Ward, J. M., & Gonzalez, F. J. (1995) · Science · doi:10.1126/science.7732381 · Cited by 1,075
The PAS Superfamily: Sensors of Environmental and Developmental Signals
Gu, Y.-Z., Hogenesch, J. B., & Bradfield, C. A. (2000) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.40.1.519 · Cited by 1,044
Schmidt, J. V., Su, G. H., Reddy, J. K., Simon, M. C., & Bradfield, C. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6731 · Cited by 902
Research works printed but not linked: 5
- Bohonowych, 2000, Activation of Ah and estrogen receptor-based cell bioassay systems by extracts of natural dietary herbal supplements, Organohalogen Compd., 45, 240
- Helferich, 1991, Photooxidized products of tryptophan can act as dioxin agonists, Mol. Pharmacol., 40, 674
- Chang, 1998, Constitutive activation of the aromatic hydrocarbon receptor, Mol. Cell. Biol., 18, 525, 10.1128/MCB.18.1.525 · DOI
- Allen, 2001, The use of a high-volume screening procedure to assess the effects of dietary flavonoids on human cyp1a1 expression, Drug Metab. Dispos., 29, 1074
- Nagy, 2002, Development of a green fluorescent protein based cell bioassay for the rapid and inexpensive detection and characterization of AhR agonists, Toxicol. Sci., 65, 200, 10.1093/toxsci/65.2.200 · DOI
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Murakami, A., Ashida, H., & Terao, J. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.03.046 · Cited by 740
Aryl hydrocarbon receptor control of a disease tolerance defence pathway
Bessede, A., Gargaro, M., Pallotta, M. T., Matino, D., Servillo, G., Brunacci, C., Bicciato, S., Mazza, E. M. C., Macchiarulo, A., Vacca, C., et al. (2014) · Nature · doi:10.1038/nature13323 · Cited by 693
Self-citationIshikawa, M., & Hashimoto, Y. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm101356p · Cited by 652
NPAS2: A Gas-Responsive Transcription Factor
Dioum, E. M., Rutter, J. P., Tuckerman, J. R., Gonzalez, G., Gilles‐Gonzalez, M., & McKnight, S. L. (2002) · Science · doi:10.1126/science.1078456 · Cited by 432
Effect-directed analysis supporting monitoring of aquatic environments — An in-depth overview
Brack, W., Aı̈t-Aı̈ssa, S., Burgess, R. M., Busch, W., Creusot, N., Paolo, C. D., Escher, B. I., Hewitt, L. M., Hilscherová, K., Hollender, J., et al. (2016) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2015.11.102 · Cited by 414
Metadata
- Authors
- Denison, M. S., Pandini, A., Nagy, S. R., Baldwin, E. P., & Bonati, L.
- Affiliations
- University of California, Davis (US)
- University of Milano-Bicocca (IT)
- Corresponding author
- Denison, Michael S
- Venue
- Chemico-Biological Interactions
- Publisher
- Elsevier BV
- Published
- 2002-09
- Volume
- 141
- Issue
- 1-2
- Pages
- 3-24
- ISSN
- 0009-2797 (ISSN-L)
- OpenAlex
- W1985754063
- Cited by
- 485
- References
- 153
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 12 · 2023: 16 · 2022: 18 · 2021: 7 · 2020: 18 · 2019: 13 · 2018: 18 · 2017: 18 · 2016: 20 · 2015: 16 · 2014: 30 · 2013: 24 · 2012: 30
- FWCI
- 15.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemico-Biological Interactions (publishedVersion)
- PubMed (publishedVersion)
- BOA (University of Milano-Bicocca) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (5r01es007072-04)
- National Institute of Environmental Health Sciences (ES07059, ES 07685, R01ES007685, ES-07072, ES5707, T32ES007059)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Keywords
- aryl hydrocarbon receptor, ligand binding, receptor activation, ligand-binding domain, aromatic hydrocarbons, crystal structure, signal transduction, transcription factors
- MeSH terms
- Animals, Binding Sites, Humans, Ligands, Protein Binding, Protein Conformation, Signal Transduction, Receptors, Aryl Hydrocarbon
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