Denison, Michael S.

The 2005 World Health Organization Reevaluation of Human and Mammalian Toxic Equivalency Factors for Dioxins and Dioxin-like Compounds

Van den Berg, M., Birnbaum, L. S., Denison, M., De Vito, M., Farland, W., Feeley, M., Fiedler, H., Hakansson, H., Hanberg, A., Haws, L., et al. (2006) · Toxicological Sciences

Toxic Organic Pollutants ImpactEffects and risks of endocrine disrupting chemicals

Cited by 3,785

Activation of the Aryl Hydrocarbon Receptor by Structurally Diverse Exogenous and Endogenous Chemicals

Denison, M. S., & Nagy, S. R. (2003) · Annual Review of Pharmacology and Toxicology

Toxic Organic Pollutants ImpactPharmacogenetics and Drug Metabolism

Cited by 1,895

Exactly the Same but Different: Promiscuity and Diversity in the Molecular Mechanisms of Action of the Aryl Hydrocarbon (Dioxin) Receptor

Denison, M. S., Soshilov, A. A., He, G., DeGroot, D. E., & Zhao, B. (2011) · Toxicological Sciences

Toxic Organic Pollutants ImpactPharmacogenetics and Drug Metabolism

Cited by 748

Ligand binding and activation of the Ah receptor

Denison, M. S., Pandini, A., Nagy, S. R., Baldwin, E. P., & Bonati, L. (2002) · Chemico-Biological Interactions

Toxic Organic Pollutants ImpactPharmacogenetics and Drug Metabolism

Cited by 485

CH223191 Is a Ligand-Selective Antagonist of the Ah (Dioxin) Receptor

Zhao, B., DeGroot, D. E., Hayashi, A., He, G., & Denison, M. S. (2010) · Toxicological Sciences

Toxic Organic Pollutants ImpactPharmacogenetics and Drug Metabolism

Cited by 312

The Ah Receptor: A Regulator of the Biochemical and Toxicological Actions of Structurally Diverse Chemicals

Denison, M. S., & Heath-Pagliuso, S. (1998) · Bulletin of Environmental Contamination and Toxicology

Toxic Organic Pollutants ImpactEffects and risks of endocrine disrupting chemicals

Cited by 258

Species-specific antagonism of Ah receptor action by 2,2′,5,5′-tetrachloro- and 2,2′,3,3′,4,4′-hexachlorobiphenyl

Aarts, J. M. M. J. G., Denison, M. S., Cox, M. A., Schalk, M. A. C., Garrison, P. M., Tullis, K., de Haan, L. H. J., & Brouwer, A. (1995) · European Journal of Pharmacology: Environmental Toxicology and Pharmacology

Toxic Organic Pollutants ImpactPharmacogenetics and Drug Metabolism

Cited by 181

Structural and Functional Characterization of the Aryl Hydrocarbon Receptor Ligand Binding Domain by Homology Modeling and Mutational Analysis

Pandini, A., Denison, M. S., Song, Y., Soshilov, A. A., & Bonati, L. (2007) · Biochemistry

Toxic Organic Pollutants ImpactProtein Structure and Dynamics

Cited by 160

Ligand Promiscuity of Aryl Hydrocarbon Receptor Agonists and Antagonists Revealed by Site-Directed Mutagenesis

Soshilov, A. A., & Denison, M. S. (2014) · Molecular and Cellular Biology

Toxic Organic Pollutants ImpactPharmacogenetics and Drug Metabolism

Cited by 128

Detection of the TCDD Binding-Fingerprint within the Ah Receptor Ligand Binding Domain by Structurally Driven Mutagenesis and Functional Analysis

Pandini, A., Soshilov, A. A., Song, Y., Zhao, J., Bonati, L., & Denison, M. S. (2009) · Biochemistry

Toxic Organic Pollutants ImpactProtein Structure and Dynamics

Cited by 124

Modeling the binding of diverse ligands within the Ah receptor ligand binding domain

Giani Tagliabue, S., Faber, S. C., Motta, S., Denison, M. S., & Bonati, L. (2019) · Scientific Reports

Computational Drug Discovery MethodsProtein Structure and Dynamics

Cited by 106

Role of the Per/Arnt/Sim Domains in Ligand-dependent Transformation of the Aryl Hydrocarbon Receptor

Soshilov, A., & Denison, M. S. (2008) · Journal of Biological Chemistry

Toxic Organic Pollutants ImpactHeat shock proteins research

Cited by 99

New Aryl Hydrocarbon Receptor Homology Model Targeted To Improve Docking Reliability

Motto, I., Bordogna, A., Soshilov, A. A., Denison, M. S., & Bonati, L. (2011) · Journal of Chemical Information and Modeling

Computational Drug Discovery MethodsProtein Structure and Dynamics

Cited by 80

Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin: Comparative studies in mammalian and nonmammalian species

Denison, M. S., Wilkinson, C. F., & Okey, A. B. (1986) · Chemosphere

Toxic Organic Pollutants ImpactPharmacogenetics and Drug Metabolism

Cited by 70

Comparative Analysis of Homology Models of the Ah Receptor Ligand Binding Domain: Verification of Structure–Function Predictions by Site-Directed Mutagenesis of a Nonfunctional Receptor

Fraccalvieri, D., Soshilov, A. A., Karchner, S. I., Franks, D. G., Pandini, A., Bonati, L., Hahn, M. E., & Denison, M. S. (2013) · Biochemistry

Toxic Organic Pollutants ImpactProtein Structure and Dynamics

Cited by 65

Analysis of the Aryl Hydrocarbon Receptor (AhR) Signal Transduction Pathway

Denison, M. S., Rogers, J. M., Rushing, S. R., Jones, C. L., Tetangco, S. C., & Heath‐Pagliuso, S. (2002) · Current Protocols in Toxicology

Toxic Organic Pollutants ImpactPharmacogenetics and Drug Metabolism

Cited by 55

Ligand Displaces Heat Shock Protein 90 from Overlapping Binding Sites within the Aryl Hydrocarbon Receptor Ligand-binding Domain

Soshilov, A., & Denison, M. S. (2011) · Journal of Biological Chemistry

Heat shock proteins researchProtein Structure and Dynamics

Cited by 49

Editor’s Highlight: Microbial-Derived 1,4-Dihydroxy-2-naphthoic Acid and Related Compounds as Aryl Hydrocarbon Receptor Agonists/Antagonists: Structure–Activity Relationships and Receptor Modeling

Cheng, Y., Jin, U.-H., Davidson, L. A., Chapkin, R. S., Jayaraman, A., Tamamis, P., Orr, A., Allred, C., Denison, M. S., Soshilov, A., et al. (2017) · Toxicological Sciences

Toxic Organic Pollutants ImpactPharmacogenetics and Drug Metabolism

Cited by 48

AHR Ligands: Promiscuity in Binding and Diversity in Response

DeGroot, D., He, G., Fraccalvieri, D., Bonati, L., Pandini, A., & Denison, M. S. (2011) · The AH Receptor in Biology and Toxicology

Toxic Organic Pollutants ImpactPharmacogenetics and Drug Metabolism

Cited by 43

Deciphering Dimerization Modes of PAS Domains: Computational and Experimental Analyses of the AhR:ARNT Complex Reveal New Insights Into the Mechanisms of AhR Transformation

Corrada, D., Soshilov, A. A., Denison, M. S., & Bonati, L. (2016) · PLOS Computational Biology

Protein Structure and DynamicsToxic Organic Pollutants Impact

Cited by 43

Transitional States in Ligand-Dependent Transformation of the Aryl Hydrocarbon Receptor into Its DNA-Binding Form

Soshilov, A. A., Motta, S., Bonati, L., & Denison, M. S. (2020) · International Journal of Molecular Sciences

Toxic Organic Pollutants ImpactHeat shock proteins research

Cited by 36

Comparative In Vitro and In Silico Analysis of the Selectivity of Indirubin as a Human Ah Receptor Agonist

Faber, S. C., Soshilov, A. A., Giani Tagliabue, S., Bonati, L., & Denison, M. S. (2018) · International Journal of Molecular Sciences

Toxic Organic Pollutants ImpactPharmacogenetics and Drug Metabolism

Cited by 36

Comparative studies of aryl hydrocarbon hydroxylase and the Ah receptor in nonmammalian species

Denison, M. S., Hamilton, J. W., & Wilkinson, C. F. (1985) · Comparative Biochemistry and Physiology Part C: Comparative Pharmacology

Toxic Organic Pollutants ImpactPharmacogenetics and Drug Metabolism

Cited by 35

Structural modeling of the AhR:ARNT complex in the bHLH–PASA–PASB region elucidates the key determinants of dimerization

Corrada, D., Denison, M. S., & Bonati, L. (2017) · Molecular BioSystems

Protein Structure and DynamicsComputational Drug Discovery Methods

Cited by 24