Bonati, Laura

Ligand binding and activation of the Ah receptor

Denison, M. S., Pandini, A., Nagy, S. R., Baldwin, E. P., & Bonati, L. (2002) · Chemico-Biological Interactions

Toxic Organic Pollutants ImpactPharmacogenetics and Drug Metabolism

Cited by 485

Structural and Functional Characterization of the Aryl Hydrocarbon Receptor Ligand Binding Domain by Homology Modeling and Mutational Analysis

Pandini, A., Denison, M. S., Song, Y., Soshilov, A. A., & Bonati, L. (2007) · Biochemistry

Toxic Organic Pollutants ImpactProtein Structure and Dynamics

Cited by 160

Detection of the TCDD Binding-Fingerprint within the Ah Receptor Ligand Binding Domain by Structurally Driven Mutagenesis and Functional Analysis

Pandini, A., Soshilov, A. A., Song, Y., Zhao, J., Bonati, L., & Denison, M. S. (2009) · Biochemistry

Toxic Organic Pollutants ImpactProtein Structure and Dynamics

Cited by 124

Predicting the accuracy of protein–ligand docking on homology models

Bordogna, A., Pandini, A., & Bonati, L. (2011) · Journal of Computational Chemistry

Computational Drug Discovery MethodsProtein Structure and Dynamics

Cited by 107

Modeling the binding of diverse ligands within the Ah receptor ligand binding domain

Giani Tagliabue, S., Faber, S. C., Motta, S., Denison, M. S., & Bonati, L. (2019) · Scientific Reports

Computational Drug Discovery MethodsProtein Structure and Dynamics

Cited by 106

New Aryl Hydrocarbon Receptor Homology Model Targeted To Improve Docking Reliability

Motto, I., Bordogna, A., Soshilov, A. A., Denison, M. S., & Bonati, L. (2011) · Journal of Chemical Information and Modeling

Computational Drug Discovery MethodsProtein Structure and Dynamics

Cited by 80

Comparative Analysis of Homology Models of the Ah Receptor Ligand Binding Domain: Verification of Structure–Function Predictions by Site-Directed Mutagenesis of a Nonfunctional Receptor

Fraccalvieri, D., Soshilov, A. A., Karchner, S. I., Franks, D. G., Pandini, A., Bonati, L., Hahn, M. E., & Denison, M. S. (2013) · Biochemistry

Toxic Organic Pollutants ImpactProtein Structure and Dynamics

Cited by 65

A model for recognition of polychlorinated dibenzo‐p‐dioxins by the aryl hydrocarbon receptor

Procopio, M., Lahm, A., Tramontano, A., Bonati, L., & Pitea, D. (2002) · European Journal of Biochemistry

Toxic Organic Pollutants ImpactProtein Structure and Dynamics

Cited by 61

AHR Ligands: Promiscuity in Binding and Diversity in Response

DeGroot, D., He, G., Fraccalvieri, D., Bonati, L., Pandini, A., & Denison, M. S. (2011) · The AH Receptor in Biology and Toxicology

Toxic Organic Pollutants ImpactPharmacogenetics and Drug Metabolism

Cited by 43

Deciphering Dimerization Modes of PAS Domains: Computational and Experimental Analyses of the AhR:ARNT Complex Reveal New Insights Into the Mechanisms of AhR Transformation

Corrada, D., Soshilov, A. A., Denison, M. S., & Bonati, L. (2016) · PLOS Computational Biology

Protein Structure and DynamicsToxic Organic Pollutants Impact

Cited by 43

Evidence that ligand binding is a key determinant of Ah receptor-mediated transcriptional activity

Murray, I. A., Reen, R. K., Leathery, N., Ramadoss, P., Bonati, L., Gonzalez, F. J., Peters, J. M., & Perdew, G. H. (2005) · Archives of Biochemistry and Biophysics

Toxic Organic Pollutants ImpactPharmacogenetics and Drug Metabolism

Cited by 41

Transitional States in Ligand-Dependent Transformation of the Aryl Hydrocarbon Receptor into Its DNA-Binding Form

Soshilov, A. A., Motta, S., Bonati, L., & Denison, M. S. (2020) · International Journal of Molecular Sciences

Toxic Organic Pollutants ImpactHeat shock proteins research

Cited by 36

Comparative In Vitro and In Silico Analysis of the Selectivity of Indirubin as a Human Ah Receptor Agonist

Faber, S. C., Soshilov, A. A., Giani Tagliabue, S., Bonati, L., & Denison, M. S. (2018) · International Journal of Molecular Sciences

Toxic Organic Pollutants ImpactPharmacogenetics and Drug Metabolism

Cited by 36

Molecular modeling of the AhR structure and interactions can shed light on ligand-dependent activation and transformation mechanisms

Bonati, L., Corrada, D., Giani Tagliabue, S., & Motta, S. (2017) · Current Opinion in Toxicology

Computational Drug Discovery MethodsProtein Structure and Dynamics

Cited by 27

Structural modeling of the AhR:ARNT complex in the bHLH–PASA–PASB region elucidates the key determinants of dimerization

Corrada, D., Denison, M. S., & Bonati, L. (2017) · Molecular BioSystems

Protein Structure and DynamicsComputational Drug Discovery Methods

Cited by 24

In vitro toxicity and in silico docking analysis of two novel selective AH-receptor modulators

Mahiout, S., Tagliabue, S. G., Nasri, A., Omoruyi, I. M., Pettersson, L., Bonati, L., & Pohjanvirta, R. (2018) · Toxicology in Vitro

Toxic Organic Pollutants ImpactCarcinogens and Genotoxicity Assessment

Cited by 19