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Cited by 193Toxic Organic Pollutants ImpactPharmacogenetics and Drug MetabolismGenomics, phytochemicals, and oxidative stress

Role of the aryl hydrocarbon receptor in cell cycle regulation

Puga, Alvaro, Xia, Ying, Elferink, Cornelis·2002·Chemico-Biological Interactions
DOI 10.1016/s0009-2797(02)00069-8
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Abstract

Traditionally, the aryl hydrocarbon receptor (AHR) is considered to be a ligand-activated receptor and transcription factor responsible for the induction of drug-metabolizing enzymes. Its role in the combinatorial matrix of cell functions was neatly established long before the first report of an AHR cDNA sequence was published. Only recently, other functions of this protein have begun to be recognized. This review addresses novel findings relating to AHR functions that have resulted from experimental approaches markedly outside traditional receptor analyses. Here we examine the aspects of AHR biology relevant to its role in cell cycle regulation, from the activation of mitogen-activated protein kinases to the cross-talk between AHR and the RAS pathway and the functional significance of the interaction between AHR and the retinoblastoma protein. We have attempted to provide the reader with a balanced interpretation of the evidence, highlighting areas of consensus as well as areas still being contested.

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Crossref · 10.1016/s0009-2797(02)00069-8

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81 of 81 references verified0 citation errors · 0 not checkable

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  • Among the 15 fixed protein-coding changes identified here but absent from previous analyses, some might have contributed to complex modifications of pathways in cell division, like AHR or DNHD1, as well as other genes with HHMCs, like CHEK1 or TOP2A.

    “Among the 15 fixed protein-coding changes identified here but absent from previous analyses1,20, some might have also contributed to complex modifications of pathways in cell division, like AHR65 or DNHD166 (Supplementary Information 1), as well as other genes with HHMCs, like CHEK167 or the gene encoding for the protein TOP2A68, which shows the largest number of interactions with other HHMC-carry”

    From A catalog of single nucleotide changes distinguishing modern humans from archaic hominins (2019) · cites this paper as [65]

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Authors
Puga, A., Xia, Y., & Elferink, C.
Affiliations
  • University of Cincinnati Medical Center (US)
  • The University of Texas Medical Branch at Galveston (US)
Corresponding author
Puga, Alvaro
ORCID
Venue
Chemico-Biological Interactions
Publisher
Elsevier BV
Published
2002-09
Volume
141
Issue
1-2
Pages
117-130
ISSN
0009-2797 (ISSN-L)
DOI
10.1016/s0009-2797(02)00069-8
OpenAlex
W2139905874
Cited by
192
References
83
Citations by year
2026: 1 · 2025: 2 · 2024: 6 · 2023: 4 · 2022: 6 · 2021: 6 · 2020: 8 · 2019: 6 · 2018: 3 · 2017: 5 · 2016: 5 · 2015: 8 · 2014: 5 · 2013: 10 · 2012: 11
FWCI
8.96
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Chemico-Biological Interactions (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Environmental Health Sciences (R01ES007800, R01ES010807, ES10807, P30ES006096, R01 ES07800, R01ES006273, P30 ES-06096, R01 ES-06273)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Keywords
aryl hydrocarbon receptor, cell cycle regulation, mitogen-activated protein kinase, Ras signaling, retinoblastoma protein, signal transduction, transcription factors, drug-metabolizing enzymes
MeSH terms
Animals, Cell Cycle, Gene Expression Regulation, Phosphorylation, Xenobiotics, Signal Transduction, Oncogene Proteins, Genes, Tumor Suppressor, Receptors, Aryl Hydrocarbon

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