Design of iron chelators with therapeutic application

Free radicals in biology and medicine

Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178

Critical Stability Constants

Martell, A. E., & Smith, R. M. (1982) · Springer eBooks · doi:10.1007/978-1-4615-6761-5 · Cited by 6,025

Free Radicals in Biology and Medicine

Land, E. J. (1990) · International Journal of Radiation Biology · doi:10.1080/09553009014552071 · Cited by 4,871

Disorders of Iron Metabolism

Andrews, N. C. (1999) · New England Journal of Medicine · doi:10.1056/nejm199912233412607 · Cited by 2,130

Hematology: Basic Principles and Practice

(1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-115-3-238_2 · Cited by 1,862

Undetectable Intracellular Free Copper: The Requirement of a Copper Chaperone for Superoxide Dismutase

Rae, T., Schmidt, P. J., Pufahl, R. A., Culotta, V., & O’Halloran, T. V. (1999) · Science · doi:10.1126/science.284.5415.805 · Cited by 1,640

Principles of bioinorganic chemistry

(1995) · Choice Reviews Online · doi:10.5860/choice.32-4515 · Cited by 1,538

Principles of bioinorganic chemistry

Chayen, J. (1995) · Cell Biochemistry and Function · doi:10.1002/cbf.290130214 · Cited by 1,060

Increased nigral iron content in postmortem parkinsonian brain

Dexter, D. T., Wells, F. R., Agid, F., Agid, Y., Lees, A. J., Jenner, P., & Marsden, C. D. (1987) · The Lancet · doi:10.1016/s0140-6736(87)91361-4 · Cited by 963

Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability

Levin, V. A. (1980) · Journal of Medicinal Chemistry · doi:10.1021/jm00180a022 · Cited by 817

Siderophore‐Linked Ruthenium Catalysts for Targeted Allyl Ester Prodrug Activation within Bacterial Cells

Southwell, J. W., Herman, R., Raines, D. J., Clarke, J. E., Böswald, I., Dreher, T., Gutenthaler, S. M., Schubert, N., Seefeldt, J., Metzler‐Nolte, N., et al. (2022) · Chemistry - A European Journal · doi:10.1002/chem.202202536 · Cited by 27

Mathematical calculations of iron complex stoichiometry by direct UV–Vis spectrophotometry

Filipský, T., Říha, M., Hrdina, R., Vávrová, K., & Mladěnka, P. (2013) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2013.06.002 · Cited by 28

Antibacterial and antibiofilm effects of iron chelators against Prevotella intermedia

Moon, J.-H., Kim, C., Lee, H., Kim, S., & Lee, J. Y. (2013) · Journal of Medical Microbiology · doi:10.1099/jmm.0.053553-0 · Cited by 28

Dirhodium (ii) carboxylate complexes as building blocks. cis-Chelating dicarboxylic acids designed to bridge the dinuclear coreElectronic supplementary information (ESI) available: Tables S1 and S2. See http://www.rsc.org/suppdata/nj/b3/b310008a/

Bickley, J. F., Bonar‐Law, R. P., McGrath, T. D., Singh, N., & Steiner, A. (2004) · New Journal of Chemistry · doi:10.1039/b310008a · Cited by 27

Complexes of hydroxy(thio)pyrone and hydroxy(thio)pyridinone with Zn( ii ) and Mo( vi ). Thermodynamic stability and insulin-mimetic activity

Chaves, S., Jelić, R., Mendonça, C., Carrasco, M. P., Yoshikawa, Y., Sakurai, H., & Santos, M. A. (2009) · Metallomics · doi:10.1039/b914169c · Cited by 27

Binding and Release of FeIII Complexes from Glucan Particles for the Delivery of T1 MRI Contrast Agents

Patel, A., Asik, D., Snyder, E. M., Dilillo, A. E., Cullen, P. J., & Morrow, J. R. (2020) · ChemMedChem · doi:10.1002/cmdc.202000003 · Cited by 27

The Iron-chelator, N,N’-bis (2-hydroxybenzyl) Ethylenediamine-N,N’-diacetic acid is an Effective Colistin Adjunct against Clinical Strains of Biofilm-Dwelling Pseudomonas aeruginosa

Mettrick, K. A., Hassan, K. A., Lamont, I. L., & Reid, D. W. (2020) · Antibiotics · doi:10.3390/antibiotics9040144 · Cited by 26

Anti-tumor activities of four chelating agents against human neuroblastoma cells.

Langtao, S., Zhao, H.-Y., Du, J., & Wang, F. (2005) · PubMed · Cited by 27

19F-MRS/1H-MRI dual-function probe for detection of β-galactosidase activity

Yu, J., Kodibagkar, V. D., Liu, L., Zhang, Z., Liu, L., Magnusson, J., & Liu, Y. (2013) · Chemical Science · doi:10.1039/c3sc21099e · Cited by 26

Mechanism Underlying the Effectiveness of Deferiprone in Alleviating Parkinson’s Disease Symptoms

Sun, Y., Pham, A. N., & Waite, T. D. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00478 · Cited by 28

Inhibitory effect of iron withdrawal by chelation on the growth of human and murine mammary carcinoma and fibrosarcoma cells

Coombs, M. R. P., Grant, T., Greenshields, A. L., Arsenault, D. J., Holbein, B. E., & Hoskin, D. W. (2015) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2015.07.008 · Cited by 25

Synthesis and Characterization of a Novel Macrocyclic Chelator with 3-Hydroxy-4-Pyrone Chelating Arms and Its Complexes with Medicinally Important Metals

Yang, C., Sreerama, S. G., Hsieh, W., & Liu, S. (2008) · Inorganic Chemistry · doi:10.1021/ic7022506 · Cited by 25

Complex Formation of 2, 6‐Bis‐(2′‐hydroxyphenyl)pyridine with AlIII, FeIII and CuII

Steinhauser, S., Heinz, U., Sander, J., & Hegetschweiler, Κ. (2004) · Zeitschrift für anorganische und allgemeine Chemie · doi:10.1002/zaac.200400235 · Cited by 25

Synthesis of novel Iron(III) chelators based on triaza macrocycle backbone and 1-hydroxy-2(H)-pyridin-2-one coordinating groups and their evaluation as antimicrobial agents

Workman, D. G., Hunter, M., Dover, L. G., & Tétard, D. (2016) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2016.04.018 · Cited by 25

Evidence for a Common Non‐Heme Chelatable‐Iron‐Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs

Stocks, P. A., Bray, P. G., Barton, V., Al‐Helal, M., Jones, M., Araújo, N., Gibbons, P. D., Ward, S. A., Hughes, R. H., Biagini, G. A., et al. (2007) · Angewandte Chemie · doi:10.1002/ange.200604697 · Cited by 25

Mn(II) complexes of monoanionic bidentate chelators: X-ray crystal structures of Mn(dha)2(CH3OH)2 (Hdha = dehydroacetic acid) and [Mn(ema)2(H2O)]2· 2H2O (Hema = 2-ethyl-3-hydroxy-4-pyrone)

Hsieh, W., Zaleski, C. M., Pecoraro, V. L., Fanwick, P. E., & Liu, S. (2005) · Inorganica Chimica Acta · doi:10.1016/j.ica.2005.09.025 · Cited by 25

Bis-(hydroxyamino)triazines: highly stable hydroxylamine-based ligands for iron(iii) cations

Gun, J., Ekeltchik, I., Lev, O. E., Shelkov, R., & Melman, A. (2005) · Chemical Communications · doi:10.1039/b508138f · Cited by 25

Biocompatible Infinite‐Coordination‐Polymer Nanoparticle–Nucleic‐Acid Conjugates for Antisense Gene Regulation

Calabrese, C. M., Merkel, T. J., Briley, W. E., Randeria, P. S., Narayan, S. P., Rouge, J. L., Walker, D., Scott, A. W., & Mirkin, C. A. (2014) · Angewandte Chemie · doi:10.1002/ange.201407946 · Cited by 24

A novel fluorescence method for determination of pFe 3 +

Ma, Y., Xie, Y., & Hider, R. C. (2012) · The Analyst · doi:10.1039/c2an36186h · Cited by 24

Amelioration of iron overload-induced liver toxicity by a potent antioxidant and iron chelator, Emblica officinalis Gaertn

Sarkar, R., Hazra, B., & Mandal, N. (2013) · Toxicology and Industrial Health · doi:10.1177/0748233713483195 · Cited by 24

DFT investigation on the selective complexation of Fe3+ and Al3+ with hydroxypyridinones used for treatment of the aluminium and iron overload diseases

Kaviani, S., Izadyar, M., & Housaindokht, M. R. (2018) · Journal of Molecular Graphics and Modelling · doi:10.1016/j.jmgm.2018.01.003 · Cited by 23

Iron chelating active packaging: Influence of competing ions and pH value on effectiveness of soluble and immobilized hydroxamate chelators

Ogiwara, Y., Roman, M. J., Decker, E. A., & Goddard, J. M. (2015) · Food Chemistry · doi:10.1016/j.foodchem.2015.10.029 · Cited by 23

Iron Binding and Iron Removal Efficiency of Desferrioxamine Based Polymeric Iron Chelators: Influence of Molecular Size and Chelator Density

Hamilton, J. L., ul‐haq, M. I., Creagh, A. L., Haynes, C. A., & Kizhakkedathu, J. N. (2016) · Macromolecular Bioscience · doi:10.1002/mabi.201600244 · Cited by 23

A field effect transistor biosensor with a γ-pyrone derivative engineered lipid-sensing layer for ultrasensitive Fe3+ ion detection with low pH interference

Nguyen, T. D. T., Labed, A., Zein, R. E., Lavandier, S., Bedu, F., Ozerov, I., Dallaporta, H., Raimundo, J., & Charrier, A. M. (2013) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2013.11.051 · Cited by 23

High affinity iron(III) scavenging by a novel hexadentate 3-hydroxypyridin-4-one-based dendrimer: Synthesis and characterization

Zhou, T., Liu, Z. D., Neubert, H., Kong, X. L., Ma, Y. M., & Hider, R. C. (2005) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2005.08.008 · Cited by 22

A Powerful Mitochondria-Targeted Iron Chelator Affords High Photoprotection against Solar Ultraviolet A Radiation

Reelfs, O., Abbate, V., Hider, R. C., & Pourzand, C. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.03.041 · Cited by 22

Synthesis, Crystal Structure and Hirshfeld Surfaces of a Cu II complex with an ICL670-related ligand

Luo, Y., Xu, J. F., & Sun, B. (2012) · Journal of Chemical Research · doi:10.3184/174751912x13503977364032 · Cited by 21

Hydroxypyridinone-Based Metal Chelators towards Ecotoxicity: Remediation and Biological Mechanisms

Santos, M. A., Irto, A., Buglyó, P., & Chaves, S. (2022) · Molecules · doi:10.3390/molecules27061966 · Cited by 21

Design of novel fluorescent mitochondria-targeted peptides with iron-selective sensing activity

Abbate, V., Reelfs, O., Hider, R. C., & Pourzand, C. (2015) · Biochemical Journal · doi:10.1042/bj20150149 · Cited by 21

Hydroxy(thio)pyrone and hydroxy(thio)pyridinone iron chelators: Physico-chemical properties and anti-oxidant activity

Chaves, S., Canário, S., Carrasco, M. P., Mira, L., & Santos, M. A. (2012) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2012.04.019 · Cited by 21

A bis(3-hydroxy-4-pyridinone)-EDTA derivative as a strong chelator for M3+ hard metal ions: complexation ability and selectivity

Gama, S., Dron, P. I., Chaves, S., Farkas, E., & Santos, M. A. (2009) · Dalton Transactions · doi:10.1039/b904950a · Cited by 21

Structure-based differences between the metal ion selectivity of two siderophores desferrioxamine B (DFB) and desferricoprogen (DFC): Why DFC is much better Pb(II) sequestering agent than DFB?

Farkas, E., Bátka, D., Kremper, G., & Pócsi, I. (2008) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2008.03.006 · Cited by 21

Modeling iron-catecholates binding to NGAL protein

Gómez‐Casado, C., Roth‐Walter, F., Jensen‐Jarolim, E., Díaz‐Perales, A., & Pacios, L. F. (2013) · Journal of Molecular Graphics and Modelling · doi:10.1016/j.jmgm.2013.08.013 · Cited by 19

Metal-Induced Isomerization Yields an Intracellular Chelator that Disrupts Bacterial Iron Homeostasis

Falconer, S. B., Wang, W., Gehrke, S. S., Cuneo, J. D., Britten, J. F., Wright, G. D., & Brown, E. D. (2013) · Chemistry & Biology · doi:10.1016/j.chembiol.2013.11.007 · Cited by 22

Computational survey of ligand properties on iron(III)–iron(II) redox potential: exploring natural attenuation of nitroaromatic compounds

Rizvi, M. A., Mane, M. V., Khuroo, M. A., & Peerzada, G. M. (2016) · Monatshefte für Chemie - Chemical Monthly · doi:10.1007/s00706-016-1813-8 · Cited by 20

Pyrophosphate functionalized silver nanoparticles for colorimetric determination of deferiprone via competitive binding to Fe(III)

Chavada, V. D., Bhatt, N. M., Sanyal, M., & Shrivastav, P. S. (2017) · Microchimica Acta · doi:10.1007/s00604-017-2417-7 · Cited by 20

Biochemical Actions of Plant Phenolics Compounds: Thermodynamic and Kinetic Aspects

Fraga, C. G., Celep, G. S., & Galleano, M. (2009) · doi:10.1002/9780470531792.ch3 · Cited by 20

Towards a new attenuating compound: A potentiometric, spectrophotometric and NMR equilibrium study on Fe(III), Al(III) and a new tetradentate mixed bisphosphonate–hydroxypyridinonate ligand

Crisponi, G., Nurchi, V. M., Pivetta, T., Gałęzowska, J., Gumienna‐Kontecka, E., Bailly, T., Burgada, R., & Kozłowski, H. (2008) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2008.01.010 · Cited by 19

Synthesis and characterisation of cis-dioxomolybdenum(vi) complexes of N-substituted 3-hydroxy-2-pyridinonesElectronic supplementary information (ESI) available: ORTEP plot and structural details of [MoO2(Lb)2]. See http://www.rsc.org/suppdata/dt/b4/b407221a/

Brown, E. J., Whitwood, A. C., Walton, P. H., & Duhme‐Klair, A. (2004) · Dalton Transactions · doi:10.1039/b407221a · Cited by 19

Pre-Clinical Evidence for the Anti-Obesity Potential of Quercetin and Curcumin Loaded Chitosan/PEG Blended PLGA Nanoparticles

Ahmed, H. H., Kotob, S. E., Abdrabou, A., Aglan, H. A., & Elmegeed, G. A. (2021) · Biomedical & Pharmacology Journal · doi:10.13005/bpj/2274 · Cited by 18

Synthesis and biological properties of iron chelators based on a bis-2-(2-hydroxy-phenyl)-thiazole-4-carboxamide or -thiocarboxamide (BHPTC) scaffold

Rodríguez‐Lucena, D., Gaboriau, F., Rivault, F., Schalk, I. J., Lescoat, G., & Mislin, G. L. A. (2009) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2009.11.057 · Cited by 18

Antiproliferative effect on HepaRG cell cultures of new calix[4]arenes

Rouge, P., Pires, V. S., Gaboriau, F., Dassonville‐Klimpt, A., Guillon, J., Nascimento, S. D., Léger, J., Lescoat, G., & Sonnet, P. (2009) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.3109/14756360903169949 · Cited by 18

Synthetic strategy of new powerful tris-bisphosphonic ligands for chelation of uranyl, iron, and cobalt cations

Burgada, R., Bailly, T., Prangé, T., & Lecouvey, M. (2007) · Tetrahedron Letters · doi:10.1016/j.tetlet.2007.01.155 · Cited by 18

Potentiometric and spectrophotometric equilibrium study on Fe(III) and new catechol-bisphosphonate conjugates

Crisponi, G., Nurchi, V. M., & Pivetta, T. (2007) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2007.07.038 · Cited by 18

Recent Developments Centered on Orally Active Iron Chelators

Hider, R. C. (2014) · Thalassemia Reports · doi:10.4081/thal.2014.2261 · Cited by 17

Opportunities and Challenges for Metal Chemistry in Molecular Imaging

Southworth, R., de Rosales, R. T. M., Meszaros, L. K., Ma, M., Mullen, G. E. D., Fruhwirth, G. O., Young, J. D., Imberti, C., Torres, J. B., Andreozzi, E. M., et al. (2015) · Advances in inorganic chemistry · doi:10.1016/bs.adioch.2015.09.001 · Cited by 17

The interaction of pyridoxal isonicotinoyl hydrazone (PIH) and salicylaldehyde isonicotinoyl hydrazone (SIH) with iron

Chen, Y., Kong, X., Xie, Y., & Hider, R. C. (2017) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2017.12.007 · Cited by 17

Siderophores

Raines, D. J., Sanderson, T. J., Wilde, E. J., & Duhme‐Klair, A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.11040-6 · Cited by 16

Combined chelation of bi-functional bis-hydroxypiridinone and mono-hydroxypiridinone: Synthesis, solution and in vivo evaluation

Gama, S., Gil, M., Gano, L., Farkas, E., & Santos, M. A. (2008) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2008.10.020 · Cited by 17

Novel S-Gal® analogs as 1H MRI reporters for in vivo detection of β-galactosidase

Gulaka, P., Yu, J.-X., Liu, L., Mason, R. P., & Kodibagkar, V. D. (2013) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2013.03.001 · Cited by 16

Synthesis and characterization of glucosyl-curcuminoids as Fe3+ suppliers in the treatment of iron deficiency

Ferrari, É., Arezzini, B., Ferrali, M., Lazzari, S., Pignedoli, F., Spagnolo, F., & Saladini, M. (2009) · BioMetals · doi:10.1007/s10534-009-9213-8 · Cited by 16

Synthesis, characterization and in vitro anticancer evaluations of two novel derivatives of deferasirox iron chelator

Salehi, S., Saljooghi, A. S., & Shiri, A. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.04.026 · Cited by 16

Beyond Biological Chelation: Coordination of f‐Block Elements by Polyhydroxamate Ligands

Sockwell, A. K., & Wetzler, M. (2018) · Chemistry - A European Journal · doi:10.1002/chem.201803176 · Cited by 16

The influence of linkages between 1-hydroxy-2(1H)-pyridinone coordinating groups and a tris(2-aminoethyl)amine core in a novel series of synthetic hexadentate iron(III) chelators on antimicrobial activity

Workman, D. G., Hunter, M., Wang, S., Brandel, J., Hubscher‐Bruder, V., Dover, L. G., & Tétard, D. (2019) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2019.103465 · Cited by 16

Chelation Therapy for Metal Intoxication: Comments from a Thermodynamic Viewpoint

Nurchi, V. M., Crespo-Alonso, M., Toso, L., Lachowicz, J. I., & Crisponi, G. (2013) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/13895575113139990077 · Cited by 17

Synthesis, Characterization, and Structures of Mn(DMHP)3·12H2O and Mn(DMHP)2Cl·0.5H2O

Hsieh, W., & Liu, S. (2005) · Inorganic Chemistry · doi:10.1021/ic0490627 · Cited by 16

Synthesis and characterization of novel β-CD-Xanthate and its application in the treatment of heavy metal containing wastewater and lignin enriched paper industry wastewater

Chaurasiya, A., Pande, P. P., Dey, K. K., Tripathi, N. P., Kumar, R., Singh, B. K., & Kumar, T. S. S. (2024) · International Journal of Environmental & Analytical Chemistry · doi:10.1080/03067319.2024.2338278 · Cited by 15

Synthesis and characterization of a triazine dendrimer that sequesters iron(III) using 12 desferrioxamine B groups

Lim, J., Venditto, V. J., & Simanek, E. E. (2010) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2010.05.039 · Cited by 15

Electronic spectroscopic characterization of the formation of iron(III) metal complexes: The 8-HydroxyQuinoline as ligand case study

Vu, T. H., Serradji, N., Seydou, M., Brémond, É. A. G., & Duong, N.-T. H. (2019) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2019.110864 · Cited by 19

Antiproliferative effect on HepaRG cell cultures of new calix[4]arenes. Part II

Latxague, L., Gaboriau, F., Chassande, O., Léger, J., Pires, V. S., Rouge, P., Dassonville‐Klimpt, A., Fardeau, S., Jarry, C., Lescoat, G., et al. (2010) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.3109/14756366.2010.489898 · Cited by 15

A new bis-(3-hydroxy-4-pyridinone)-DTPA-derivative: Synthesis, complexation of di-/tri-valent metal cations and in vivo M3+ sequestering ability

Irto, A., Cardiano, P., Chand, K., Cigala, R. M., Crea, F., Stefano, C. D., Gano, L., Gattuso, G., Sammartano, S., & Santos, M. A. (2019) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2019.02.042 · Cited by 15

Iron (III) chelation and antioxidant properties of myo-inositol phosphorylated polymeric microspheres

Iemma, F., Cirillo, G., Puoci, F., Trombino, S., Castiglione, M., & Picci, N. (2007) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.59.4.0016 · Cited by 15

Physicochemical and functional properties of beany flavour‐free bambara groundnut protein isolate

Kudre, T. G., & Benjakul, S. (2013) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.6404 · Cited by 15

Combined chelation based on glycosyl-mono- and bis-hydroxypyridinones for aluminium mobilization: Solution and biodistribution studies

Chaves, S., Dron, P. I., Danalache, F. A., Sacoto, D., Gano, L., & Santos, M. A. (2009) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2009.07.026 · Cited by 14

Synthesis and Antioxidant Efficiency of a New Copolymer Containing Phosphorylated Myo‐Inositol

Iemma, F., Trombino, S., Puoci, F., Cirillo, G., Spizzirri, U. G., Muzzalupo, R., & Picci, N. (2005) · Macromolecular Bioscience · doi:10.1002/mabi.200500136 · Cited by 14

Iron Chelating Agents for Iron Overload Diseases

Crisponi, G., Nurchi, V. M., & Zoroddu, M. A. (2014) · Thalassemia Reports · doi:10.4081/thal.2014.2046 · Cited by 14

Effectiveness of deferiprone-loaded nanocarrier in experimentally induced rhabdomyolysis: A dose-comparison study

Rashed, R. R., Deghiedy, N. M., El‐Hazek, R. M., El‐Sabbagh, W. A., Rashed, E. R., & El‐Ghazaly, M. A. (2020) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2020.103913 · Cited by 14

Schiff base pyrazolone complexes of iron (III): synthesis, characterization, antimicrobial and antioxidant activity

Surati, K. R., & Sathe, P. A. (2016) · Medicinal Chemistry Research · doi:10.1007/s00044-016-1649-0 · Cited by 14

Tuning the redox potentials of ternary cobalt(III) complexes containing various hydroxamates

Buglyó, P., Kacsir, I., Kozsup, M., Nagy, I., Nagy, S., Bényei, A. C., Kováts, É., & Farkas, E. (2017) · Inorganica Chimica Acta · doi:10.1016/j.ica.2017.07.026 · Cited by 15

Antibiotic Activity of Iron-Sequestering Polymers

El-Gendy, N. A., Qian, J., Eshelman, K., Rivera, M., & Berkland, C. J. (2015) · Biomacromolecules · doi:10.1021/bm5016392 · Cited by 14

Iron(III)-selective dendritic chelators

Zhou, T., Hider, R. C., Liu, Z. D., & Neubert, H. (2004) · Tetrahedron Letters · doi:10.1016/j.tetlet.2004.10.110 · Cited by 14

Desferrioxamine release from gelatin‐based systems

Ulubayram, K., Kızıltay, A., Yılmaz, E., & Hasırcı, N. (2005) · Biotechnology and Applied Biochemistry · doi:10.1042/ba20050084 · Cited by 14

Polyglycerol-Based Macromolecular Iron Chelator Adjuvants for Antibiotics To Treat Drug-Resistant Bacteria

Abbina, S., Gill, A., Mathew, S., Abbasi, U., & Kizhakkedathu, J. N. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c06501 · Cited by 14

Practical Management of Iron Overload Disorder (IOD) in Black Rhinoceros (BR; Diceros bicornis)

Sullivan, K. E., Mylniczenko, N. D., Nelson, S. E., Coffin, B., & Lavin, S. R. (2020) · Animals · doi:10.3390/ani10111991 · Cited by 13

New hydrophilic 3-hydroxy-4-pyridinone chelators with ether-derived substituents: Synthesis and evaluation of analytical performance in the determination of iron in waters

Moniz, T., Cunha-Silva, L., Mesquita, R. B. R., Miranda, J. L. A., Silva, A. M. N., Silva, A. M. G., Rangel, A. O. S. S., de Castro, B., & Rangel, M. (2018) · Polyhedron · doi:10.1016/j.poly.2018.12.005 · Cited by 13

Synthesis and Characterization of Cr(III) Complexes with 3‐Hydroxy‐4‐Pyrones and 1,2‐Dimethyl‐3‐Hydroxy‐4‐Pyridinone (DMHP): X‐Ray Crystal Structures of Cr(DMHP)3 · 12H2O and Cr(ma)3

Hsieh, W., & Liu, S. (2005) · Synthesis and Reactivity in Inorganic Metal-Organic and Nano-Metal Chemistry · doi:10.1081/sim-200047549 · Cited by 13

Glycosyl‐Curcuminoids as Potential New Chelating Agents in Iron Overload Chelation Therapy

Arezzini, B., Ferrali, M., Ferrari, É., Grandi, R., Monti, S., & Saladini, M. (2004) · European Journal of Inorganic Chemistry · doi:10.1002/ejic.200300463 · Cited by 13

A Macrophage Cell Model for Selective Metalloproteinase Inhibitor Design

Jacobsen, F. E., Buczynski, M. W., Dennis, E. A., & Cohen, S. M. (2008) · ChemBioChem · doi:10.1002/cbic.200800148 · Cited by 12

Design, synthesis and redox properties of two ferrocene-containing iron chelators

Moggia, F., Brisset, H., Fagès, F., Chaix, C., Mandrand, B., Dias, M., & Levillain, E. (2006) · Tetrahedron Letters · doi:10.1016/j.tetlet.2006.03.088 · Cited by 12

A theoretical study on the electronic structures and equilibrium constants evaluation of Deferasirox iron complexes

Salehi, S., Saljooghi, A. S., & Izadyar, M. (2016) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2016.05.010 · Cited by 10

Therapeutic Macromolecular Iron Chelators

Bulbake, U., Singh, A., Domb, A. J., & Khan, W. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180904104318 · Cited by 11

Iron(III) Tris(pyridinehydroxamate)s and Related Nickel(II) and Zinc(II) Complexes: Potential Platforms for the Design of Novel Heterodimetallic Supramolecular Assemblies

Mulcahy, C., Krot, K. A., Griffith, D. M., Suponitsky, K. Y., Starikova, Z. A., & Marmion, C. J. (2007) · European Journal of Inorganic Chemistry · doi:10.1002/ejic.200600758 · Cited by 11

Preparation, physicochemical characterization and biological evaluation of cefodizime metal ion complexes

Auda, S. H., Mrestani, Y., Nies, D. H., Gro�e, C., & Neubert, R. H. H. (2009) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.61.06.0007 · Cited by 11

Design and synthesis of conjugated azo-hydrazone analogues using nano BF3·SiO2 targeting ROS homeostasis in oncogenic and vascular progression

Zabiulla, Z., Vigneshwaran, V., Bushra, A. B., Pavankumar, G. S., Prabhakar, B. T., & Khanum, S. A. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.08.076 · Cited by 10

High Antiproliferative Activity of Hydroxythiopyridones over Hydroxypyridones and Their Organoruthenium Complexes

Shakil, M. S., Parveen, S., Rana, Z., Walsh, F. P., Movassaghi, S., Söhnel, T., Azam, M., Shaheen, M. A., Jamieson, S. M. F., Hanif, M., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9020123 · Cited by 10

Design of Tetrazolium Cations for the Release of Antiproliferative Formazan Chelators in Mammalian Cells

Xu, Z., Sung, Y., & Tomat, E. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.3c02033 · Cited by 10

Repurposing iron chelators for accurate positron emission tomography imaging tracking of radiometal‐labeled cell transplants

Xu, Q., Wang, X., Mu, Z., Zhou, Y., Ding, X., Ji, X., Yan, J., Pan, D., Chen, C., Xu, Y., et al. (2024) · MedComm · doi:10.1002/mco2.473 · Cited by 10

Discovering Novel and Diverse Iron-Chelators in Silico

Basu, A., Sohn, Y., Alyan, M., Nechushtai, R., Domb, A. J., & Goldblum, A. (2016) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.6b00450 · Cited by 10

Chelation of Thallium (III) in Rats Using Combined Deferasirox and Deferiprone Therapy

Salehi, S., Saljooghi, A. S., Badiee, S., & Moqadam, M. M. (2017) · Toxicological Research · doi:10.5487/tr.2017.33.4.299 · Cited by 10

Synthesis, characterization and electrochemistry studies of iron(III) complex with curcumin ligand

Özbolat, G., Yegani, A. A., & Tuli, A. (2018) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12964 · Cited by 10

Hydroxypyrone derivatives in drug discovery: from chelation therapy to rational design of metalloenzyme inhibitors

Arshad, J. Z., & Hanif, M. (2022) · RSC Medicinal Chemistry · doi:10.1039/d2md00175f · Cited by 10

The Design of Multifunctional Antioxidants Against the Damaging Ingredients of Oxidative Stress

Mecklenburg, S., Collins, C. A., Döring, M., Burkholz, T., Abbas, M., Fry, F. H., Pourzand, C., & Jacob, C. (2008) · Phosphorus, sulfur, and silicon and the related elements · doi:10.1080/10426500801898200 · Cited by 10

New asymmetric heptaaza Schiff base macrocyclic complex of Mn(II): Crystal structure, biological and DFT studies

Khanmohammadi, H., Amani, S., Abnosi, M. H., & Khavasi, H. R. (2010) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2010.02.001 · Cited by 10

Synthesis of Modular Desferrioxamine Analogues and Evaluation of Zwitterionic Derivatives for Zirconium Complexation

Outzen, L., Münzmay, M., Frangioni, J. V., & Maison, W. (2023) · ChemMedChem · doi:10.1002/cmdc.202300112 · Cited by 9

Interaction of Imidazole Containing Hydroxamic Acids with Fe(III): Hydroxamate Versus Imidazole Coordination of the Ligands

Farkas, E., Bátka, D., Csóka, H., & May, N. V. (2007) · Bioinorganic Chemistry and Applications · doi:10.1155/2007/96536 · Cited by 10

New hexadentate tris(dopamine) as iron chelating agent: Synthesis, solution thermodynamic stability and antioxidant activity studies

Zhang, Q., Jin, B., Feng, S., Zheng, T., Wang, X., Guo, Z., & Peng, R. (2019) · Polyhedron · doi:10.1016/j.poly.2018.12.053 · Cited by 9

Multicellular aggregation of maltol-modified cells triggered by Fe3+ ions

Ciupa, A., Bank, P. D., & Caggiano, L. (2013) · Chemical Communications · doi:10.1039/c3cc43727b · Cited by 9

Synthèse de ligands bisphosphoniques pour la complexation de l’ion uranyle du cobalt et du fer

Burgada, R., Bailly, T., & Lecouvey, M. (2004) · Comptes Rendus Chimie · doi:10.1016/j.crci.2003.09.007 · Cited by 9

Synthesis, characterization and molecular docking studies of phenoxyimine based ligands: Cytotoxicity, hemolytic activity and antioxidant assessment

Sajjan, V. P., Anigol, L. B., Gurubasavaraj, P. M., Kotresha, D., Pradhan, S. S., Venkatesh, S., & Patil, D. (2022) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2022.133457 · Cited by 8

Forms of Iron Binding in the Cells and the Chemical Features of Chelation Therapy

Puntarulo, S., & Galleano, M. (2009) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955709788922674 · Cited by 8

Design of clinically useful iron(III)‐selective chelators

Liu, Z. D., & Hider, R. C. (2002) · Medicinal Research Reviews · doi:10.1002/med.1027 · Cited by 266

Iron Chelator Chemistry

Liu, Z. D., Liu, D. Y., & Hider, R. C. (2002) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-0593-8_8 · Cited by 15

The Design of Orally Active Iron Chelators

HIDER, R. C., & ZHOU, T. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1345.017 · Cited by 64

Iron Chelator Design

Hider, R. C., Epemolu, O., Singh, S., & Porter, J. B. (1994) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-2554-7_36 · Cited by 19

Coordination Chemistry of Novel Drug Candidates for the Treatment of Iron Overload

Norin, A. (2007) · KTH Publication Database DiVA (KTH Royal Institute of Technology)