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Design of iron chelators with therapeutic application
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“By contrast, bidentate or tridentate chelators that bind to only 2 or 3 of the available iron chelation sites, especially when they bind to both Fe(II) and Fe(III), can in fact catalyse redox cycling and thereby promote free radical generation [1437,1665,1670,1671].”
From Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases (2009) · cites this paper as [1670]
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Metadata
- Authors
- Liu, Z. D., & Hider, R. C.
- Affiliations
- King's College London (GB)
- Corresponding author
- Hider, Robert C
- ORCID
- Hider, Robert C
- Venue
- Coordination Chemistry Reviews
- Publisher
- Elsevier BV
- Published
- 2002-10
- Volume
- 232
- Issue
- 1-2
- Pages
- 151-171
- ISSN
- 0010-8545 (ISSN-L)
- OpenAlex
- W1990645562
- Cited by
- 287
- References
- 132
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 9 · 2023: 7 · 2022: 10 · 2021: 6 · 2020: 12 · 2019: 10 · 2018: 10 · 2017: 14 · 2016: 13 · 2015: 21 · 2014: 12 · 2013: 24 · 2012: 13
- FWCI
- 5.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Coordination Chemistry Reviews (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Oncology › Metal complexes synthesis and properties
- Physical Sciences › Chemistry › Inorganic Chemistry › Inorganic and Organometallic Chemistry
- Keywords
- iron chelators, iron overload, desferrioxamine B, oral bioavailability, metal ion selectivity, iron(III) complexes, hydroxamate, hydroxypyridinone, triazoles, ligand design, toxicity, bioavailability
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