Increased nigral iron content in postmortem parkinsonian brain
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Several studies have shown increases of total iron concentration in the substantia nigra of patients with Parkinson's disease.
“Several studies have shown increases of total iron concentration in the substantia nigra of patients with Parkinson’s disease.”
From The role of iron in brain ageing and neurodegenerative disorders (2014) · cites this paper as [100]
Neuropathological studies using accurate spectroscopic methods showed that iron concentrations in the substantia nigra pars compacta and reticulata increase with disease severity.
“Neuropathological studies that used accurate spectroscopic methods to measure total iron concentrations in specific brain regions, such as substantia nigra pars compacta and reticulata showed that iron concentrations in these regions increase with disease severity.100–103”
From The role of iron in brain ageing and neurodegenerative disorders (2014) · cites this paper as [100]
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- Authors
- Dexter, D. T., Wells, F. R., Agid, F., Agid, Y., Lees, A. J., Jenner, P., & Marsden, C. D.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1987-11
- Volume
- 330
- Issue
- 8569
- Pages
- 1219-1220
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2039403847
- Cited by
- 963
- References
- 7
- Citations by year
- 2026: 11 · 2025: 15 · 2024: 17 · 2023: 19 · 2022: 28 · 2021: 28 · 2020: 31 · 2019: 35 · 2018: 22 · 2017: 32 · 2016: 25 · 2015: 44 · 2014: 28 · 2013: 27 · 2012: 18
- FWCI
- 26.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Keywords
- substantia nigra, iron content, Parkinson's disease, postmortem brain, iron accumulation
- MeSH terms
- Aged, Humans, Iron, Parkinson Disease, Substantia Nigra
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