Zebrafish Rho Kinase 2 Acts Downstream of Wnt11 to Mediate Cell Polarity and Effective Convergence and Extension Movements
Open accessAbstract
Background During vertebrate gastrulation convergence and extension (CE), movements narrow and lengthen embryonic tissues. In Xenopus and zebrafish, a noncanonical Wnt signaling pathway constitutes the vertebrate counterpart to the Drosophila planar cell polarity pathway and regulates mediolateral cell polarization underlying CE. Despite the identification of several signaling molecules required for normal CE, the downstream transducers regulating individual cell behaviors driving CE are only beginning to be elucidated. Moreover, how defective mediolateral cell polarity impacts CE is not understood.Results Here, we show that overexpression of zebrafish dominant-negative Rho kinase 2 (dnRok2) disrupts CE without altering cell fates, phenocopying noncanonical Wnt signaling mutants. Moreover, Rho kinase 2 (Rok2) overexpression partially suppresses the slb/wnt11 gastrulation phenotype, and ectopic expression of noncanonical Wnts modulates Rok2 intracellular distribution. In addition, time-lapse analyses associate defective dorsal convergence movements with impaired cell elongation, mediolateral orientation, and consequently failure to migrate along straight paths. Transplantation experiments reveal that dnRok2 cells in wild-type hosts neither elongate nor orient their axes. In contrast, wild-type cells are able to elongate their cell bodies in dnRok2 hosts, even though they fail to orient their axes.Conclusions During zebrafish gastrulation, Rok2 acts downstream of noncanonical Wnt11 signaling to mediate mediolateral cell elongation required for dorsal cell movement along straight paths. Furthermore, elongation and orientation of the cell body are independent properties that require both cell-autonomous and nonautonomous Rok2 function.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Activation of Rho GTPase leads to the activation of the Rho-associated kinase (ROCK) and myosin, which leads to modification of the actin cytoskeleton and cytoskeletal rearrangement.
“Activation of Rho GTPase leads to the activation of the Rho-associated kinase (ROCK)82 and myosin,83 which leads to modification of the actin cytoskeleton and cytoskeletal rearrangement.”
From Wnt signal transduction pathways (2008) · cites this paper as [82]
Cites
Stages of embryonic development of the zebrafish
Kimmel, C. B., Ballard, W. W., Kimmel, S. R., Ullmann, B., & Schilling, T. F. (1995) · Developmental Dynamics · doi:10.1002/aja.1002030302 · Cited by 12,037 · see citing works
The zebrafish book : a guide for the laboratory use of zebrafish (Danio rerio)
Westerfield, M. (1995) · Medical Entomology and Zoology · Cited by 6,813 · see citing works
Krauss, S. J. K., Concordet, J., & Ingham, P. W. (1993) · Cell · doi:10.1016/0092-8674(93)90628-4 · Cited by 1,072 · see citing works
Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation
Heisenberg, C.-P., Tada, M., Rauch, G.-J., Saúde, L., Concha, M. L., Geisler, R., Stemple, D. L., Smith, J. C., & Wilson, S. W. (2000) · Nature · doi:10.1038/35011068 · Cited by 1,013 · see citing works
Semenza, G. L. (2001) · Cell · doi:10.1016/s0092-8674(01)00518-9 · Cited by 935 · see citing works
LEUNG, T. K. C., Chen, X., Manser, E. J., & Lim, L. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.10.5313 · Cited by 902 · see citing works
Habas, R., Kato, Y., & He, X. (2001) · Cell · doi:10.1016/s0092-8674(01)00614-6 · Cited by 842 · see citing works
Dishevelled controls cell polarity during Xenopus gastrulation
Wallingford, J. B., Rowning, B. A., Vogeli, K. M., Rothbächer, U., Fraser, S. E., & Harland, R. M. (2000) · Nature · doi:10.1038/35011077 · Cited by 751 · see citing works
Mechanism and function of signal transduction by the Wnt/β-catenin and Wnt/Ca2+ pathways
Miller, J. R., Hocking, A. M., Brown, J. D., & Moon, R. T. (1999) · Oncogene · doi:10.1038/sj.onc.1203245 · Cited by 689 · see citing works
Tada, M., & Smith, J. C. (2000) · Development · doi:10.1242/dev.127.10.2227 · Cited by 675 · see citing works
Schulte‐Merker, S., Ho, R. K., Herrmann, B. G., & Nüsslein‐Volhard, C. (1992) · Development · doi:10.1242/dev.116.4.1021 · Cited by 644 · see citing works
Akimenko, M., Ekker, M., Wegner, J., Lin, W., & Westerfield, M. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-06-03475.1994 · Cited by 606 · see citing works
Cell movements during epiboly and gastrulation in zebrafish
Warga, R. M., & Kimmel, C. B. (1990) · Development · doi:10.1242/dev.108.4.569 · Cited by 574 · see citing works
Winter, C. G., Wang, B., Ballew, A. C., Royou, A., Karess, R. E., Axelrod, J. D., & Luo, L. (2001) · Cell · doi:10.1016/s0092-8674(01)00298-7 · Cited by 555 · see citing works
Mechanisms of convergence and extension by cell intercalation
Keller, R. E., Davidson, L. A., Edlund, A., Elul, T., Ezin, M., Shook, D. R., & Skoglund, P. (2000) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2000.0626 · Cited by 521 · see citing works
Regulation and Functions of Rho-Associated Kinase
Amano, M., Fukata, Y., & Kaibuchi, K. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.5046 · Cited by 518 · see citing works
Ishizaki, T., Naito, M., Fujisawa, K., Maekawa, M., Watanabe, N., Saito, Y., & Narumiya, S. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00107-5 · Cited by 515 · see citing works
Efficient recovery of ENU-induced mutations from the zebrafish germline.
Solnica‐Krezel, L., Schier, A. F., & Driever, W. (1994) · Genetics · doi:10.1093/genetics/136.4.1401 · Cited by 496 · see citing works
Self-citationTopczewski, J., Sepich, D. S., Myers, D. C., Walker, C., Amores, A., Lele, Z., Hammerschmidt, M., Postlethwait, J. H., & Solnica‐Krezel, L. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00005-3 · Cited by 454 · see citing works
Self-citationAnalysis of Dishevelled signalling pathways during Xenopus development
Sokol, S. Y. (1996) · Current Biology · doi:10.1016/s0960-9822(96)00750-6 · Cited by 406 · see citing works
Canalization in evolutionary genetics: a stabilizing theory?
Gibson, G. C., & Wagner, G. P. (2000) · BioEssays · doi:10.1002/(sici)1521-1878(200004)22:4 · Cited by 345 · see citing works
Moon, R. T., Campbell, R. M., Christian, J. L., McGrew, L. L., Shih, J., & Fraser, S. E. (1993) · Development · doi:10.1242/dev.119.1.97 · Cited by 330 · see citing works
Djiane, A., Riou, J.-F., Umbhauer, M., Boucaut, J.-C., & Shi, D.-L. (2000) · Development · doi:10.1242/dev.127.14.3091 · Cited by 316 · see citing works
The COOH Terminus of Rho-kinase Negatively Regulates Rho-kinase Activity
Amano, M., Chihara, K., Nakamura, N., Kaneko, T., Matsuura, Y., & Kaibuchi, K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.45.32418 · Cited by 272 · see citing works
Concha, M. L., & Adams, R. J. (1998) · Development · doi:10.1242/dev.125.6.983 · Cited by 237 · see citing works
goosecoid Expression in neurectoderm and mesendoderm is disrupted in zebrafish cyclops gastrulas
Thisse, C., Thisse, B., Halpern, M. E., & Postlethwait, J. H. (1994) · Developmental Biology · doi:10.1006/dbio.1994.1212 · Cited by 230 · see citing works
Rho kinases play an obligatory role in vertebrate embryonic organogenesis
Wei, L., Roberts, W. B., Wang, L., Yamada, M., Zhang, S., Zhao, Z., Rivkees, S. A., Schwartz, R. J., & Imanaka‐Yoshida, K. (2001) · Development · doi:10.1242/dev.128.15.2953 · Cited by 224 · see citing works
Yamamoto, A., Amacher, S. L., Kim, S., Geissert, D., Kimmel, C. B., & Robertis, E. M. D. (1998) · Development · doi:10.1242/dev.125.17.3389 · Cited by 219 · see citing works
Hammerschmidt, M., Serbedzija, G. N., & McMahon, A. P. (1996) · Genes & Development · doi:10.1101/gad.10.19.2452 · Cited by 217 · see citing works
Verde, F., Wiley, D. J., & Nurse, P. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7526 · Cited by 217 · see citing works
Conservation of BMP signaling in zebrafish mesoderm patterning
Nikaido, M., Tada, M., Saji, T., & Ueno, N. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(96)00625-9 · Cited by 208 · see citing works
Bmp Activity Gradient Regulates Convergent Extension during Zebrafish Gastrulation
Myers, D. C., Sepich, D. S., & Solnica‐Krezel, L. (2002) · Developmental Biology · doi:10.1006/dbio.2001.0523 · Cited by 193 · see citing works
Self-citationPlanar polarity in the Drosophila eye: a multifaceted view of signaling specificity and cross‐talk
Mlodzik, M. (1999) · The EMBO Journal · doi:10.1093/emboj/18.24.6873 · Cited by 172 · see citing works
Wissmann, A., Ingles, J., McGhee, J. D., & Mains, P. E. (1997) · Genes & Development · doi:10.1101/gad.11.4.409 · Cited by 170 · see citing works
Yasui, Y., Amano, M., Nagata, K., Inagaki, N., Nakamura, H., Saya, H., Kaibuchi, K., & Inagaki, M. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.5.1249 · Cited by 165 · see citing works
Frizzled-8 is expressed in the Spemann organizer and plays a role in early morphogenesis
Deardorff, M. A., Tan, C. L., Conrad, L. J., & Klein, P. S. (1998) · Development · doi:10.1242/dev.125.14.2687 · Cited by 160 · see citing works
Marlow, F. L., Zwartkruis, F. J. T., Malicki, J. J., Neuhauss, S. C. F., Abbas, L., Weaver, M., Driever, W., & Solnica‐Krezel, L. (1998) · Developmental Biology · doi:10.1006/dbio.1998.9032 · Cited by 138 · see citing works
Self-citationWnt4 affects morphogenesis when misexpressed in the zebrafish embryo
Ungar, A. R., Kelly, G. M., & Moon, R. T. (1995) · Mechanisms of Development · doi:10.1016/0925-4773(95)00386-f · Cited by 132 · see citing works
The Function ofsilberblickin the Positioning of the Eye Anlage in the Zebrafish Embryo
Heisenberg, C., & Nüsslein‐Volhard, C. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8511 · Cited by 126 · see citing works
Zebrafish wnt11: pattern and regulation of the expression by the yolk cell and No tail activity
Makita, R., Mizuno, T., Koshida, S., Kuroiwa, A., & Takeda, H. (1998) · Mechanisms of Development · doi:10.1016/s0925-4773(98)00013-6 · Cited by 88 · see citing works
A role for Wnts in morpho-genesis and tissue polarity
Sokol, S. Y. (2000) · Nature Cell Biology · doi:10.1038/35017136 · Cited by 84 · see citing works
The midblastula transition, the YSL transition and the onset of gastrulation in Fundulus
Trinkaus, J. P. (1992) · Development · doi:10.1242/dev.116.supplement.75 · Cited by 47 · see citing works
Genetic analysis of the exed region in mouse
Kendall, S. K., Strong, S. J., Litman, R. T., Litman, G. W., & Magnuson, T. (2000) · genesis · doi:10.1002/1526-968x(200008)27:4
Flagged first, then by citations
Cited by
Sorted by citations
ROCKs: multifunctional kinases in cell behaviour
Riento, K., & Ridley, A. J. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1128 · Cited by 1,941 · see citing works
Wnt signal transduction pathways
Komiya, Y., & Habas, R. (2008) · Organogenesis · doi:10.4161/org.4.2.5851 · Cited by 1,528 · see citing works
Veeman, M. T., Axelrod, J. D., & Moon, R. T. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00266-1 · Cited by 1,359 · see citing works
Purified Wnt5a Protein Activates or Inhibits β-Catenin–TCF Signaling Depending on Receptor Context
Mikels, A. J., & Nusse, R. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040115 · Cited by 1,244 · see citing works
Towards an integrated view of Wnt signaling in development
van Amerongen, R., & Nusse, R. (2009) · Development · doi:10.1242/dev.033910 · Cited by 1,168 · see citing works
Rho‐kinase/ROCK: A key regulator of the cytoskeleton and cell polarity
Amano, M., Nakayama, M., & Kaibuchi, K. (2010) · Cytoskeleton · doi:10.1002/cm.20472 · Cited by 994 · see citing works
Mechanotransduction in development: a growing role for contractility
Wozniak, M. A., & Chen, C. S. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2592 · Cited by 821 · see citing works
Tensile forces govern germ-layer organization in zebrafish
Krieg, M., Arboleda-Estudillo, Y., Puech, P., Käfer, J., Graner, F., Müller, D. J., & Heisenberg, C. (2008) · Nature Cell Biology · doi:10.1038/ncb1705 · Cited by 804 · see citing works
Shaping the Vertebrate Body Plan by Polarized Embryonic Cell Movements
Keller, R. E. (2002) · Science · doi:10.1126/science.1079478 · Cited by 716 · see citing works
The genetic basis of mammalian neurulation
Copp, A. J., Greene, N. D. E., & Murdoch, J. N. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1181 · Cited by 695 · see citing works
Force Generation, Transmission, and Integration during Cell and Tissue Morphogenesis
Lecuit, T., Lenne, P.-F., & Munro, E. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100109-104027 · Cited by 621 · see citing works
Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation
Habas, R., Dawid, I. B., & He, X. (2003) · Genes & Development · doi:10.1101/gad.1022203 · Cited by 603 · see citing works
Principles of planar polarity in animal development
Goodrich, L. V., & Strutt, D. I. (2011) · Development · doi:10.1242/dev.054080 · Cited by 568 · see citing works
Planar Cell Polarity Signaling: From Fly Development to Human Disease
Simons, M., & Mlodzik, M. (2008) · Annual Review of Genetics · doi:10.1146/annurev.genet.42.110807.091432 · Cited by 570 · see citing works
Boland, G. M., Perkins, G., Hall, D. J., & Tuan, R. S. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20284 · Cited by 568 · see citing works
Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility
Seifert, J. R. K., & Mlodzik, M. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2042 · Cited by 513 · see citing works
Tao, Q., Yokota, C., Puck, H., Kofron, M., Birsoy, B., Yan, D., Asashima, M., Wylie, C. C., Lin, X., & Heasman, J. (2005) · Cell · doi:10.1016/j.cell.2005.01.013 · Cited by 510 · see citing works
The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity
Wallingford, J. B., & Habas, R. (2005) · Development · doi:10.1242/dev.02068 · Cited by 509 · see citing works
Zebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movements
Jessen, J. R., Topczewski, J., Bingham, S., Sepich, D. S., Marlow, F., Chandrasekhar, A., & Solnica-Krezel, L. (2002) · Nature Cell Biology · doi:10.1038/ncb828 · Cited by 504 · see citing works
Self-citationHow we are shaped: The biomechanics of gastrulation
Keller, R. E., Davidson, L. A., & Shook, D. R. (2003) · Differentiation · doi:10.1046/j.1432-0436.2003.710301.x · Cited by 495 · see citing works
Molecular Genetics of Axis Formation in Zebrafish
Schier, A. F., & Talbot, W. S. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.37.110801.143752 · Cited by 489 · see citing works
Majumdar, Å., Vainio, S. J., Kispert, A., McMahon, J. A., & McMahon, A. P. (2003) · Development · doi:10.1242/dev.00520 · Cited by 475 · see citing works
Mechanobiology and Developmental Control
Mammoto, T., Mammoto, A., & Ingber, D. E. (2013) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122340 · Cited by 436 · see citing works
Wnt signaling controls the fate of mesenchymal stem cells
Ling, L., Nurcombe, V., & Cool, S. M. (2008) · Gene · doi:10.1016/j.gene.2008.12.008 · Cited by 417 · see citing works
Migration of Zebrafish Primordial Germ Cells: A Role for Myosin Contraction and Cytoplasmic Flow
Blaser, H., Reichman‐Fried, M., Castanon, I., Dumstrei, K., Marlow, F. L., Kawakami, K., Solnica‐Krezel, L., Heisenberg, C., & Raz, E. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.09.023 · Cited by 406 · see citing works
Self-citationAlternative Wnt Signaling Is Initiated by Distinct Receptors
van Amerongen, R., Mikels, A. J., & Nusse, R. (2008) · Science Signaling · doi:10.1126/scisignal.135re9 · Cited by 395 · see citing works
Conserved Patterns of Cell Movements during Vertebrate Gastrulation
Solnica-Krezel, L. (2005) · Current Biology · doi:10.1016/j.cub.2005.03.016 · Cited by 391 · see citing works
Self-citationA Wnt Survival Guide: From Flies to Human Disease
Chien, A. J., Conrad, W. H., & Moon, R. T. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.445 · Cited by 377 · see citing works
Wnt-Frizzled/Planar Cell Polarity Signaling: Cellular Orientation by Facing the Wind (Wnt)
Yang, Y., & Mlodzik, M. (2015) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100814-125315 · Cited by 361 · see citing works
Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis
Karner, C. M., Chirumamilla, R., Aoki, S., Igarashi, P., Wallingford, J. B., & Carroll, T. J. (2009) · Nature Genetics · doi:10.1038/ng.400 · Cited by 370 · see citing works
Wnt signaling pathways meet Rho GTPasesPreprint
Schlessinger, K., Hall, A., & Tolwinski, N. S. (2009) · Genes & Development · doi:10.1101/gad.1760809 · Cited by 366 · see citing works
Gastrulation: Making and Shaping Germ Layers
Solnica‐Krezel, L., & Sepich, D. S. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154043 · Cited by 366 · see citing works
Self-citationThree Functions of Cadherins in Cell Adhesion
Maître, J., & Heisenberg, C. (2013) · Current Biology · doi:10.1016/j.cub.2013.06.019 · Cited by 345 · see citing works
Mlodzik, M. (2002) · Trends in Genetics · doi:10.1016/s0168-9525(02)02770-1 · Cited by 341 · see citing works
Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure
Ybot‐González, P., Savery, D., Gerrelli, D., Signore, M., Mitchell, C. E., Faux, C. H., Greene, N. D. E., & Copp, A. J. (2007) · Development · doi:10.1242/dev.000380 · Cited by 330 · see citing works
The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation
Kilian, B., Mansukoski, H., Carreira-Barbosa, F., Ulrich, F., Tada, M., & Heisenberg, C. (2003) · Mechanisms of Development · doi:10.1016/s0925-4773(03)00004-2 · Cited by 327 · see citing works
Planar Cell Polarity: Coordinating Morphogenetic Cell Behaviors with Embryonic Polarity
Gray, R. S., Roszko, I., & Solnica‐Krezel, L. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.06.011 · Cited by 314 · see citing works
Self-citationPLANAR CELL POLARIZATION: An Emerging Model Points in the Right Direction
Klein, T. J., & Mlodzik, M. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.012704.132806 · Cited by 311 · see citing works
Nishimura, T., & Takeichi, M. (2008) · Development · doi:10.1242/dev.019646 · Cited by 312 · see citing works
Wallingford, J. B., & Mitchell, B. J. (2011) · Genes & Development · doi:10.1101/gad.2008011 · Cited by 304 · see citing works
Rho-Kinase Directs Bazooka/Par-3 Planar Polarity during Drosophila Axis Elongation
Simões, S. D. M., Blankenship, J. T., Weitz, O., Farrell, D. L., Tamada, M., Fernández‐González, R., & Zallen, J. A. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.08.011 · Cited by 274 · see citing works
Prickle 1 regulates cell movements during gastrulation and neuronal migration in zebrafish
Carreira-Barbosa, F., Concha, M. L., Takeuchi, M., Ueno, N., Wilson, S. W., & Tada, M. (2003) · Development · doi:10.1242/dev.00567 · Cited by 269 · see citing works
Matthews, H. K., Marchant, L., Carmona‐Fontaine, C., Kuriyama, S., Larraı́n, J., Holt, M., Parsons, M., & Mayor, R. (2008) · Development · doi:10.1242/dev.017350 · Cited by 267 · see citing works
Heart Field: From Mesoderm to Heart Tube
Abu‐Issa, R., & Kirby, M. L. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123331 · Cited by 261 · see citing works
Planar Cell Polarity and the Developmental Control of Cell Behavior in Vertebrate Embryos
Wallingford, J. B. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154208 · Cited by 251 · see citing works
The Wnt signaling pathway in cellular proliferation and differentiation: A tale of two coactivators
Teo, J.-L., & Kahn, M. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.09.012 · Cited by 248 · see citing works
Biology and Physics of Cell Shape Changes in Development
Paluch, E. K., & Heisenberg, C. (2009) · Current Biology · doi:10.1016/j.cub.2009.07.029 · Cited by 250 · see citing works
Jenny, A., Darken, R. S., Wilson, P. A., & Mlodzik, M. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg424 · Cited by 245 · see citing works
Frizzled signalling and cell polarisation inDrosophilaand vertebrates
Strutt, D. I. (2003) · Development · doi:10.1242/dev.00695 · Cited by 243 · see citing works
Roszko, I., Sawada, A., & Solnica‐Krezel, L. (2009) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2009.09.004 · Cited by 230 · see citing works
Self-citationInternational Union of Basic and Clinical Pharmacology. LXXX. The Class Frizzled Receptors
Schulte, G. (2010) · Pharmacological Reviews · doi:10.1124/pr.110.002931 · Cited by 227 · see citing works
WNT11 acts as a directional cue to organize the elongation of early muscle fibres
Gros, J., Serralbo, O., & Marcelle, C. (2008) · Nature · doi:10.1038/nature07564 · Cited by 210 · see citing works
Dishevelled and Wnt signaling: is the nucleus the final frontier?
Habas, R., & Dawid, I. B. (2005) · Journal of Biology · doi:10.1186/jbiol22 · Cited by 211 · see citing works
Gastrulation Movements: the Logic and the Nuts and Bolts
Leptin, M. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.02.007 · Cited by 201 · see citing works
Actin and microtubules drive differential aspects of planar cell polarity in multiciliated cells
Werner, M. E., Hwang, P., Huisman, F. M., Taborek, P., Yu, C. C., & Mitchell, B. J. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201106110 · Cited by 210 · see citing works
Marsden, M., & DeSimone, D. W. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00433-0 · Cited by 205 · see citing works
Planar cell polarity signaling, cilia and polarized ciliary beating
Wallingford, J. B. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.07.011 · Cited by 191 · see citing works
Cell Movements at Hensen’s Node Establish Left/Right Asymmetric Gene Expression in the Chick
Gros, J., Feistel, K., Viebahn, C., Blum, M., & Tabin, C. J. (2009) · Science · doi:10.1126/science.1172478 · Cited by 189 · see citing works
Compartmentalized morphogenesis in epithelia: From cell to tissue shape
Pilot‐Storck, F., & Lecuit, T. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20334 · Cited by 181 · see citing works
Mechanism of activation of the Formin protein Daam1
Liu, W., Sato, A., Khadka, D., Bharti, R., Diaz, H., Runnels, L. W., & Habas, R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707277105 · Cited by 173 · see citing works
Myers, D. C., Sepich, D. S., & Solnica‐Krezel, L. (2002) · Trends in Genetics · doi:10.1016/s0168-9525(02)02725-7 · Cited by 169 · see citing works
Self-citationSlb/Wnt11 controls hypoblast cell migration and morphogenesis at the onset of zebrafish gastrulation
Ulrich, F., Concha, M. L., Heid, P. J., Voss, E. R., Witzel, S., Roehl, H. H., Tada, M., Wilson, S. W., Adams, R. J., Soll, D. R., et al. (2003) · Development · doi:10.1242/dev.00758 · Cited by 165 · see citing works
Planar cell polarity signaling in vertebrates
Jones, C., & Chen, P. (2007) · BioEssays · doi:10.1002/bies.20526 · Cited by 161 · see citing works
The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis
Yates, L. L., Schnatwinkel, C., Murdoch, J. N., Bogani, D., Formstone, C. J., Townsend, S., Greenfield, A., Niswander, L. A., & Dean, C. H. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq104 · Cited by 160 · see citing works
Planar cell polarity in moving cells: think globally, act locally
Davey, C. F., & Moens, C. B. (2017) · Development · doi:10.1242/dev.122804 · Cited by 149 · see citing works
Distinct functions of Rho and Rac are required for convergent extension during Xenopus gastrulation
Tahinci, E., & Symes, K. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00206-9 · Cited by 162 · see citing works
Identification of a novel Wnt5a–CK1ε–Dvl2–Plk1‐mediated primary cilia disassembly pathway
Lee, K. H., Johmura, Y., Yu, L., Park, J., Gao, Y., Bang, J. K., Zhou, M., Veenstra, T. D., Kim, B. Y., & Lee, K. S. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.144 · Cited by 159 · see citing works
Wnt/Fz signaling and the cytoskeleton: potential roles in tumorigenesis
Lai, S.-L., Chien, A. J., & Moon, R. T. (2009) · Cell Research · doi:10.1038/cr.2009.41 · Cited by 158 · see citing works
E-cadherin is required for gastrulation cell movements in zebrafish
Shimizu, T., Yabe, T., Muraoka, O., Yonemura, S., Aramaki, S., Hatta, K., Bae, Y., Nojima, H., & Hibi, M. (2005) · Mechanisms of Development · doi:10.1016/j.mod.2005.03.008 · Cited by 155 · see citing works
Paraxial protocadherin coordinates cell polarity during convergent extension via Rho A and JNK
Unterseher, F., Hefele, J. A., Giehl, K., Robertis, E. M. D., Wedlich, D., & Schambony, A. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600332 · Cited by 153 · see citing works
Rasputin, more promiscuous than ever: a review of G3BP
Irvine, K. M., Richards, R. S., Hume, D. A., & Kennedy, D. D. (2004) · The International Journal of Developmental Biology · doi:10.1387/ijdb.041893ki · Cited by 148 · see citing works
Hashimoto, H., Robin, F., Sherrard, K. M., & Munro, E. (2015) · Developmental Cell · doi:10.1016/j.devcel.2014.12.017 · Cited by 144 · see citing works
Bakkers, J., Kramer, C., Pothof, J., Quaedvlieg, N. E. M., Spaink, H. P., & Hammerschmidt, M. (2004) · Development · doi:10.1242/dev.00954 · Cited by 137 · see citing works
Wnt/Frizzled Signaling Controls C. elegans Gastrulation by Activating Actomyosin Contractility
Lee, J.-Y., Marston, D. J., Walston, T., Hardin, J. D., Halberstadt, A. I., & Goldstein, B. (2006) · Current Biology · doi:10.1016/j.cub.2006.08.090 · Cited by 134 · see citing works
Cell movement during chick primitive streak formation
Chuai, M., Zeng, W., Yang, X., Boychenko, V., Glazier, J. A., & Weijer, C. J. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.04.451 · Cited by 131 · see citing works
Wnt-3a and Dvl Induce Neurite Retraction by Activating Rho-Associated Kinase
Kishida, S., Yamamoto, H., & Kikuchi, A. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.10.4487-4501.2004 · Cited by 129 · see citing works
RhoA/ROCK Signaling Suppresses Hypertrophic Chondrocyte Differentiation
Wang, G., Woods, A., Sabari, S., Pagnotta, L., Stanton, L., & Beier, F. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311427200 · Cited by 128 · see citing works
Wnt signaling during development of the gastrointestinal tract
Theodosiou, N. A., & Tabin, C. J. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00185-4 · Cited by 127 · see citing works
Coming to Consensus: A Unifying Model Emerges for Convergent Extension
Huebner, R. J., & Wallingford, J. B. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.08.003 · Cited by 126 · see citing works
Spatial organization of adhesion: force‐dependent regulation and function in tissue morphogenesis
Papusheva, E., & Heisenberg, C. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.182 · Cited by 121 · see citing works
Subcellular Localization and Signaling Properties of Dishevelled in Developing Vertebrate Embryos
Park, T. J., Gray, R. S., Sato, A., Habas, R., & Wallingford, J. B. (2005) · Current Biology · doi:10.1016/j.cub.2005.04.062 · Cited by 119 · see citing works
Mammary Development and Breast Cancer: A Wnt Perspective
Yu, Q. C., Verheyen, E. M., & Zeng, Y. A. (2016) · Cancers · doi:10.3390/cancers8070065 · Cited by 116 · see citing works
Wallingford, J. B. (2005) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.30054 · Cited by 116 · see citing works
Phosphorylation-Dependent Regulation of WNT/Beta-Catenin Signaling
Shah, K., & Kazi, J. U. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.858782 · Cited by 116 · see citing works
Zhu, S., Liu, L., Korzh, V. P., Gong, Z., & Low, B. C. (2005) · Cellular Signalling · doi:10.1016/j.cellsig.2005.05.019 · Cited by 114 · see citing works
Garriock, R. J., D'Agostino, S. L., Pilcher, K. C., & Krieg, P. A. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2004.12.013 · Cited by 114 · see citing works
Richardson, R. J., Metzger, M., Knyphausen, P., Ramezani, T., Slanchev, K., Kraus, C., Schmelzer, E., & Hammerschmidt, M. (2016) · Development · doi:10.1242/dev.130492 · Cited by 112 · see citing works
Zebrafish Gastrulation: Cell Movements, Signals, and Mechanisms
Rohde, L. A., & Heisenberg, C. (2007) · International review of cytology · doi:10.1016/s0074-7696(07)61004-3 · Cited by 107 · see citing works
Ouko, L., Ziegler, T. R., Gu, L. H., Eisenberg, L. M., & Yang, V. W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402877200 · Cited by 109 · see citing works
Lin, F. H., Sepich, D. S., Chen, S., Topczewski, J., Yin, C., Solnica‐Krezel, L., & Hamm, H. E. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200501104 · Cited by 107 · see citing works
Self-citationOssipova, O., Kim, K., & Sokol, S. Y. (2015) · Biology Open · doi:10.1242/bio.201511676 · Cited by 102 · see citing works
Analysis of tissue flow patterns during primitive streak formation in the chick embryo
Cui, C., Yang, X., Chuai, M., Glazier, J. A., & Weijer, C. J. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.04.021 · Cited by 106 · see citing works
Kim, G., & Han, J. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20262 · Cited by 103 · see citing works
Sato, A., Khadka, D., Liu, W., Bharti, R., Runnels, L. W., Dawid, I. B., & Habas, R. (2006) · Development · doi:10.1242/dev.02590 · Cited by 102 · see citing works
Adhesion remodeling underlying tissue morphogenesis
Lecuit, T. (2004) · Trends in Cell Biology · doi:10.1016/j.tcb.2004.11.007 · Cited by 103 · see citing works
McGreevy, E. M., Vijayraghavan, D. S., Davidson, L. A., & Hildebrand, J. D. (2015) · Biology Open · doi:10.1242/bio.20149589 · Cited by 104 · see citing works
Marikawa, Y., Tamashiro, D. A. A., Fujita, T. C., & Alarcón, V. B. (2008) · genesis · doi:10.1002/dvg.20473 · Cited by 101 · see citing works
Shp2 Knockdown and Noonan/LEOPARD Mutant Shp2–Induced Gastrulation Defects
Jopling, C., van Geemen, D., & den Hertog, J. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030225 · Cited by 99 · see citing works
Initiation of convergence and extension movements of lateral mesoderm during zebrafish gastrulation
Sepich, D. S., Calmelet, C., Kiskowski, M. A., & Solnica‐Krezel, L. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20507 · Cited by 98 · see citing works
Self-citationInterplay of mechanical deformation and patterned gene expression in developing embryos
Brouzes, E. R., & Farge, E. (2004) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2004.06.005 · Cited by 98 · see citing works
- Authors
- Marlow, F., Topczewski, J., Sepich, D., & Solnica-Krezel, L.
- Affiliations
- Vanderbilt University (US)
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2002-06
- Volume
- 12
- Issue
- 11
- Pages
- 876-884
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W1964743891
- Cited by
- 337
- References
- 43
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 1 · 2023: 6 · 2022: 10 · 2021: 14 · 2020: 7 · 2019: 7 · 2018: 6 · 2017: 12 · 2016: 11 · 2015: 15 · 2014: 12 · 2013: 12 · 2012: 14
- FWCI
- 8.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (T32HL007751, T32-HL07751)
- National Institute of General Medical Sciences (GM55101, R01GM055101)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Keywords
- Wnt11, non-canonical Wnt signaling, convergence and extension, gastrulation, cell polarity, cell migration, planar cell polarity, zebrafish embryos
- MeSH terms
- Animals, Base Sequence, Embryo, Nonmammalian, Glycoproteins, Oligonucleotides, Zebrafish, Signal Transduction, Cell Polarity, Protein Serine-Threonine Kinases, Cell Lineage, Xenopus Proteins, Zebrafish Proteins, Embryonic Development, Intracellular Signaling Peptides and Proteins, Wnt Proteins, rho-Associated Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
