Zebrafish Rho Kinase 2 Acts Downstream of Wnt11 to Mediate Cell Polarity and Effective Convergence and Extension Movements
Open accessAbstract
Background During vertebrate gastrulation convergence and extension (CE), movements narrow and lengthen embryonic tissues. In Xenopus and zebrafish, a noncanonical Wnt signaling pathway constitutes the vertebrate counterpart to the Drosophila planar cell polarity pathway and regulates mediolateral cell polarization underlying CE. Despite the identification of several signaling molecules required for normal CE, the downstream transducers regulating individual cell behaviors driving CE are only beginning to be elucidated. Moreover, how defective mediolateral cell polarity impacts CE is not understood.Results Here, we show that overexpression of zebrafish dominant-negative Rho kinase 2 (dnRok2) disrupts CE without altering cell fates, phenocopying noncanonical Wnt signaling mutants. Moreover, Rho kinase 2 (Rok2) overexpression partially suppresses the slb/wnt11 gastrulation phenotype, and ectopic expression of noncanonical Wnts modulates Rok2 intracellular distribution. In addition, time-lapse analyses associate defective dorsal convergence movements with impaired cell elongation, mediolateral orientation, and consequently failure to migrate along straight paths. Transplantation experiments reveal that dnRok2 cells in wild-type hosts neither elongate nor orient their axes. In contrast, wild-type cells are able to elongate their cell bodies in dnRok2 hosts, even though they fail to orient their axes.Conclusions During zebrafish gastrulation, Rok2 acts downstream of noncanonical Wnt11 signaling to mediate mediolateral cell elongation required for dorsal cell movement along straight paths. Furthermore, elongation and orientation of the cell body are independent properties that require both cell-autonomous and nonautonomous Rok2 function.
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Activation of Rho GTPase leads to the activation of the Rho-associated kinase (ROCK) and myosin, which leads to modification of the actin cytoskeleton and cytoskeletal rearrangement.
“Activation of Rho GTPase leads to the activation of the Rho-associated kinase (ROCK)82 and myosin,83 which leads to modification of the actin cytoskeleton and cytoskeletal rearrangement.”
From Wnt signal transduction pathways (2008) · cites this paper as [82]
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- Authors
- Marlow, F., Topczewski, J., Sepich, D., & Solnica-Krezel, L.
- Affiliations
- Vanderbilt University (US)
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2002-06
- Volume
- 12
- Issue
- 11
- Pages
- 876-884
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W1964743891
- Cited by
- 337
- References
- 43
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 1 · 2023: 6 · 2022: 10 · 2021: 14 · 2020: 7 · 2019: 7 · 2018: 6 · 2017: 12 · 2016: 11 · 2015: 15 · 2014: 12 · 2013: 12 · 2012: 14
- FWCI
- 8.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (T32HL007751, T32-HL07751)
- National Institute of General Medical Sciences (GM55101, R01GM055101)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Keywords
- Wnt11, non-canonical Wnt signaling, convergence and extension, gastrulation, cell polarity, cell migration, planar cell polarity, zebrafish embryos
- MeSH terms
- Animals, Base Sequence, Embryo, Nonmammalian, Glycoproteins, Oligonucleotides, Zebrafish, Signal Transduction, Cell Polarity, Protein Serine-Threonine Kinases, Cell Lineage, Xenopus Proteins, Zebrafish Proteins, Embryonic Development, Intracellular Signaling Peptides and Proteins, Wnt Proteins, rho-Associated Kinases
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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