The DOI matches its Crossref record.
Stimulation of δ1- and δ2-opioid receptors produces amnesia in mice
Abstract
The effects of intracerebroventricular administration of delta1- and delta2-selective opioid receptor agonists on spontaneous alternation performance, elevated plus-maze behavior and passive avoidance learning including step-down and step-through types were examined in mice. Although the delta1-selective opioid receptor agonist, [D-Pen2,L-Pen5]enkephalin (DPLPE) (1-10 microg) or the delta2-selective opioid receptor agonist, [D-Ala2]deltorphin II (deltorphin) (1-10 microg) did not markedly affect spontaneous alternation performance or elevated plus-maze behavior, DPLPE (1, 3 and/or 10 microg) and deltorphin (3 and 10 microg) inhibited passive avoidance learning including step-down and step-through types. The delta1-selective opioid receptor antagonist, 7-benzylidenenaltrexone (3.5 ng), and the delta2-selective opioid receptor antagonist, naltriben (19 ng), significantly antagonized the inhibitory effects of DPLPE (3 microg) and deltorphin (3 microg) on passive avoidance learning, respectively. In contrast, DPLPE (3 microg) or deltorphin (3 microg) did not markedly influence behavioral responses induced by electroshocks during training of passive avoidance learning. Moreover, DPLPE (0.3-3 microg) or deltorphin (0.3-3 microg) failed to significantly affect the radiant heat-induced nociceptive responses. These results suggest that stimulation of delta1- and delta2-opioid receptors produces amnesia, depending on the learning tasks used.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Importantly, opioid receptor antagonists appear to reverse the effects of opioid agonists (Ukai et al., 1997;Zhu et al., 2011), and even facilitate memory performance (Canli et al., 1990;Gallagher et al., 1983).”
From A review of the relation between dissociation, memory, executive functioning and social cognition in military members and civilians with neuropsychiatric conditions (2016) · cites this paper as Ukai et al., 1997
In the citing paper
“Specifically, treatment with opioid agonists have been reported to interfere with acquisition (Spain and Newsom, 1991;Zhu et al., 2011) and retrieval (Zhu et al., 2011) of spatial memories, and to disrupt working memory (Itoh et al., 1994), avoidance learning (Aguilar et al., 1998;Ukai et al., 1997;Zarrindast and Rezayof, 2004), and spatial recognition memory (Ma et al., 2007).”
From A review of the relation between dissociation, memory, executive functioning and social cognition in military members and civilians with neuropsychiatric conditions (2016) · cites this paper as Ukai et al., 1997
In the citing paper
“Opioid receptors are present throughout the cortex and limbic system (Le Merrer et al., 2009) and opioids have been implicated in memory disturbance in the animal literature (Itoh et al., 1994;Ma et al., 2007;Ukai et al., 1997;Zhu et al., 2011).”
From A review of the relation between dissociation, memory, executive functioning and social cognition in military members and civilians with neuropsychiatric conditions (2016) · cites this paper as Ukai et al., 1997
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 37
- Beninger, 1986, Effects of scopolamine and unilateral lesions of the basal forebrain on T-maze spatial discrimination and alternation in rats, Pharmacol. Biochem. Behav., 24, 1353, 10.1016/0091-3057(86)90195-4 · DOI
- Bhargava, 1996, Effects of chronic administration of 7-benzylidene-7-dehydronaltrexone and naltriben on the antinociceptive actions of δ1- and δ2-opioid receptor agonists, Eur. J. Pharmacol., 311, 127, 10.1016/0014-2999(96)00411-6 · DOI
- De Wied, 1978, Behavioral and electrophysiological effects of peptides related to lipotropin (β-LPH), J. Pharmacol. Exp. Ther., 204, 570, 10.1016/S0022-3565(25)31174-2 · DOI
- Dhawan, 1996, International union of pharmacology. XII. Classification of opioid receptors, Pharmacol. Rev., 48, 567, 10.1016/S0031-6997(25)06958-3 · DOI
- Erspamer, 1989, Deltorphins: A family of naturally occurring peptides with high affinity and selectivity for δ opioid binding sites, Proc. Natl. Acad. Sci. USA, 86, 5188, 10.1073/pnas.86.13.5188 · DOI
- Fang, 1994, Characterization of [3H]naltrindole binding to delta opioid receptors in mouse brain and mouse vas deferens: Evidence for delta opioid receptor heterogeneity, J. Pharmacol. Exp. Ther., 268, 836, 10.1016/S0022-3565(25)39017-8 · DOI
- Fowler, 1994, μ-, δ-, κ-Opioid receptors and their subtypes: A critical review with emphasis on radioligand binding experiments, Neurochem. Int., 24, 401, 10.1016/0197-0186(94)90089-2 · DOI
- Haley, 1957, Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse, Br. J. Pharmacol., 12, 12
- Hammond, 1995, Antinociception and δ-1 opioid receptors in the rat spinal cord: Studies with intrathecal 7-benzylidenenaltrexone, J. Pharmacol. Exp. Ther., 274, 1317, 10.1016/S0022-3565(25)10651-4 · DOI
- Hiller, 1987, Selective changes in mu, delta, and kappa opioid receptor binding in certain limbic regions of the brain in Alzheimer's disease patients, Brain Res., 106, 17, 10.1016/0006-8993(87)90764-5 · DOI
- Itoh, 1990, Utility of an elevated plus-maze for the evaluation of memory in mice: Effects of nootropics, scopolamine and electroconvulsive shock, Psychopharmacology, 101, 27, 10.1007/BF02253713 · DOI
- Itoh, 1993, Dynorphin A-(1-13) markedly improves scopolamine-induced impairment of spontaneous alternation performance in mice, Eur. J. Pharmacol., 236, 341, 10.1016/0014-2999(93)90469-X · DOI
- Itoh, 1994, Dynorphin A-(1-13) potently improves the impairment of spontaneous alternation performance induced by the μ-selective opioid receptor agonist DAMGO in mice, J. Pharmacol. Exp. Ther., 269, 15, 10.1016/S0022-3565(25)38666-0 · DOI · Paper page
- Izquierdo, 1980, Effect of β-endorphin and naloxone on acquisition, memory, and retrieval of shuttle avoidance and habituation learning in rats, Psychopharmacology, 69, 111, 10.1007/BF00426531 · DOI
- Jiang, 1991, Differential antagonism of opioid delta-antinociception by [d-Ala2,Leu5,Cys6]enkephalin and naltrindole 5′-isothiocyanate: Evidence for delta-receptor subtypes, J. Pharmacol. Exp. Ther., 257, 1069, 10.1016/S0022-3565(25)24666-3 · DOI
- Kameyama, 1986, Step-down-type passive avoidance- and escape-learning method suitability for experimental amnesia models, J. Pharmacol. Methods, 16, 39, 10.1016/0160-5402(86)90027-6 · DOI
- Martin, 1984, Pharmacology of opioids, Pharmacol. Rev., 35, 283, 10.1016/S0031-6997(25)06637-2 · DOI
- Martinez, 1980, Endorphins after acquisition and consolidation of an inhibitory avoidance response in rats, Neurosci. Lett., 19, 197, 10.1016/0304-3940(80)90194-9 · DOI
- Mosberg, 1983, Bis-penicillamine enkephalins possess highly improved specificity towards delta opioid receptors, Proc. Natl. Acad. Sci. USA, 80, 5871, 10.1073/pnas.80.19.5871 · DOI
- Mulder, 1984, κ- and δ-opioid receptor agonists differentially inhibit striatal dopamine and acetylcholine release, Nature, 308, 278, 10.1038/308278a0 · DOI
- Parada-Turska, 1990, Excitatory amino acid antagonists and memory: Effect of drugs acting at N-methyl-d-aspartate receptors in learning and memory tasks, Neuropharmacology, 29, 1111, 10.1016/0028-3908(90)90034-O · DOI
- Pasternak, 1993, Pharmacological mechanisms of opioid analgesics, Clin. Neuropharmacol., 16, 1, 10.1097/00002826-199302000-00001 · DOI
- Paterson, 1983, Classification of opioid receptors, Br. Med. Bull., 39, 25, 10.1093/oxfordjournals.bmb.a071787 · DOI
- Portoghese, 1992, A highly selective δ1-opioid receptor antagonist: 7-Benzylidenenaltrexone, Eur. J. Pharmacol., 218, 195, 10.1016/0014-2999(92)90167-3 · DOI
- Rady, 1994, Supraspinal delta receptor subtype activity of heroin and 6-monoacetylmorphine in Swiss Webster mice, Life Sci., 55, 603, 10.1016/0024-3205(94)00486-2 · DOI
- Sarter, 1988, Attenuation of scopolamine-induced impairment of spontaneous alternation behavior by antagonist but not inverse agonist and agonist β-carbolines, Psychopharmacology, 94, 491, 10.1007/BF00212843 · DOI
- Schulteis, 1988, Stimulation and antagonism of opioid δ-receptors produce opposite effects on active avoidance conditioning in mice, Behav. Neurosci., 102, 678, 10.1037/0735-7044.102.5.678 · DOI
- Sofuoglu, 1991, Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: Evidence for delta opioid receptor subtypes, J. Pharmacol. Exp. Ther., 257, 676, 10.1016/S0022-3565(25)24699-7 · DOI
- Stahl, S.M., 1996. Essential Psychopharmacology: Neuroscientific Basis and Practical Applications. Cambridge University Press, Cambridge.
- Takemori, 1993, The mixed antinociceptive agonist-antagonist activity of β-endorphin (1–27) in mice, Life Sci., 53, 1049, 10.1016/0024-3205(93)90257-4 · DOI
- Tjon, 1995, Intermittent and chronic treatment induces long-lasting changes in δ-opioid receptor-regulated acetylcholine release in rat striatum and nucleus accumbens, Eur. J. Pharmacol., 283, 169, 10.1016/0014-2999(95)00319-G · DOI
- Ukai, 1993, Dynorphin A-(1–13) attenuates basal forebrain-lesion-induced amnesia in rats, Brain Res., 625, 355, 10.1016/0006-8993(93)91082-4 · DOI
- Ukai, 1995, Dynorphin A-(1–13) potently improves scopolamine-induced impairment of passive avoidance response in mice, Eur. J. Pharmacol., 274, 89, 10.1016/0014-2999(94)00710-O · DOI
- Ukai, 1995, κ-Opioid receptor agonists improve pirenzepine-induced disturbance of spontaneous alternation performance in the mouse, Eur. J. Pharmacol., 281, 173, 10.1016/0014-2999(95)00239-H · DOI
- Ukai, 1995, Attenuation of memory with Tyr-d-Arg–Phe-β-Ala–NH2, a novel dermorphin analog, with high affinity for μ-opioid receptors, Eur. J. Pharmacol., 287, 245, 10.1016/0014-2999(95)00492-0 · DOI
- Walker, 1991, Naloxone modulates the behavioral effects of cholinergic agonists and antagonists, Psychopharmacology, 105, 57, 10.1007/BF02316864 · DOI
- Wüster, 1981, Multiple opiate receptors in peripheral tissue preparations, Biochem. Pharmacol., 30, 1883, 10.1016/0006-2952(81)90194-5 · DOI
Cited by
Sorted by citations
McKinnon, M. C., Boyd, J. E., Frewen, P. A., Lanius, U. F., Jetly, R., Richardson, J. D., & Lanius, R. A. (2016) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2016.07.017 · Cited by 94
“Importantly, opioid receptor antagonists appear to reverse the effects of opioid agonists (Ukai et al., 1997; Zhu et al., 2011), and even facilitate memory performance (Canli et al., 1990; Gallagher et al., 1983).”
Hirata, H., Sonoda, S., Agui, S., Yoshida, M., Ohinata, K., & Yoshikawa, M. (2007) · Peptides · doi:10.1016/j.peptides.2007.07.024 · Cited by 89
Metadata
- Authors
- Ukai, M., Takada, A., Sasaki, Y., & Kameyama, T.
- Affiliations
- Meijo University (JP)
- Corresponding author
- Ukai, Makoto
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 1997-10
- Volume
- 338
- Issue
- 1
- Pages
- 1-6
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W2084977336
- Cited by
- 33
- References
- 0
- Citations by year
- 2023: 1 · 2020: 1 · 2019: 2 · 2016: 2 · 2015: 2 · 2013: 3
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- opioid agonists, amnesia, passive avoidance learning, spontaneous alternation, elevated plus maze, deltorphin, 7-benzylidenenaltrexone, naltriben, nociception
- MeSH terms
- Amnesia, Analgesia, Animals, Avoidance Learning, Behavior, Animal, Electroshock, Enkephalins, Male, Oligopeptides, Receptors, Opioid, delta, Enkephalin, D-Penicillamine (2,5)-, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Stimulation of δ1- and δ2-opioid receptors produces amnesia in mice. https://app.cochat.ai/papers/10.1016/s0014-2999(97)01310-1
- The paper
- Ukai, M., Takada, A., Sasaki, Y., & Kameyama, T. (1997). Stimulation of δ1- and δ2-opioid receptors produces amnesia in mice. European Journal of Pharmacology. https://doi.org/10.1016/s0014-2999(97)01310-1
