Cited by 117Nicotinic Acetylcholine Receptors StudyNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Effects of nicotine and mecamylamine on rat dorsal raphe neurons

Mihailescu, Stefan, Palomero-Rivero, Marcela, Meade-Huerta, Patricia, Maza-Flores, Axeneth, Drucker-Colı́n, René·1998·European Journal of Pharmacology

Abstract

This study investigates the hypothesis that serotonin mediates certain nicotine effects, such as mood improvement and the suppression of the ponto-geniculo-occipital spikes of rapid eye movement sleep. The influence of nicotine (10-300 microM) on the firing rate of dorsal raphe neurons and on serotonin release was therefore, studied in rat midbrain slices. Nicotine increased the firing rate, 10-90%, in 67.5% recorded neurons and decreased it, 8-100%, in the remaining 32.5%. Serotonin release increased 2-7 times after nicotine administration, regardless of firing frequency, but the absolute value of serotonin release was 3 times higher during the decreases than during the increases in firing rate. Mecamylamine (1-20 microM) transiently stimulated the dorsal raphe neurons and competitively antagonized the nicotine-induced serotonin release. The results support the working hypothesis and additionally show that mecamylamine also stimulates dorsal raphe neurons.

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Crossref · 10.1016/s0014-2999(98)00658-x

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33 of 33 references verified0 citation errors · 0 not checkable

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  • Nicotine influences the rate of dorsal raphe nucleus (DRN) neuron firing, and can increase serotonin release in rat midbrain slices, an effect largely mediated by presynaptic enhancement of both norepinephrine and glutamate release.

    “Nicotine influences the rate of dorsal raphe nucleus (DRN) neuron firing, and can increase serotonin release in rat midbrain slices (Mihailescu et al., 1998), an effect that appears to be largely mediated by presynaptic enhancement of both norepinephrine (Li et al., 1998) and glutamate release (Garduno et al., 2012).”

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Authors
Mihailescu, S., Palomero-Rivero, M., Meade-Huerta, P., Maza-Flores, A., & Drucker-Colı́n, R.
Affiliations
Universidad Nacional Autónoma de México (MX)
Corresponding author
Drucker-Colı́n, René
Venue
European Journal of Pharmacology
Publisher
Elsevier BV
Published
1998-10
Volume
360
Issue
1
Pages
31-36
ISSN
0014-2999 (ISSN-L)
OpenAlex
W2031305942
Cited by
117
References
33
Citations by year
2024: 3 · 2021: 1 · 2020: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 4 · 2013: 7 · 2012: 6
FWCI
1.74
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
nicotine, mecamylamine, dorsal raphe nucleus, serotonin release, neuronal firing rate, nicotinic acetylcholine receptors, serotonergic neurotransmission, REM sleep suppression, mood improvement
MeSH terms
Action Potentials, Animals, Electrophysiology, Ganglionic Stimulants, Male, Mecamylamine, Neurons, Nicotine, Raphe Nuclei, Serotonin, Rats, Wistar, Nicotinic Antagonists, Rats, In Vitro Techniques

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