Cited by 117Nicotinic Acetylcholine Receptors StudyNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

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Effects of nicotine and mecamylamine on rat dorsal raphe neurons

Mihailescu, Stefan, Palomero-Rivero, Marcela, Meade-Huerta, Patricia, Maza-Flores, Axeneth, Drucker-Colı́n, René·1998·European Journal of Pharmacology

DOI 10.1016/s0014-2999(98)00658-x

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Abstract

This study investigates the hypothesis that serotonin mediates certain nicotine effects, such as mood improvement and the suppression of the ponto-geniculo-occipital spikes of rapid eye movement sleep. The influence of nicotine (10-300 microM) on the firing rate of dorsal raphe neurons and on serotonin release was therefore, studied in rat midbrain slices. Nicotine increased the firing rate, 10-90%, in 67.5% recorded neurons and decreased it, 8-100%, in the remaining 32.5%. Serotonin release increased 2-7 times after nicotine administration, regardless of firing frequency, but the absolute value of serotonin release was 3 times higher during the decreases than during the increases in firing rate. Mecamylamine (1-20 microM) transiently stimulated the dorsal raphe neurons and competitively antagonized the nicotine-induced serotonin release. The results support the working hypothesis and additionally show that mecamylamine also stimulates dorsal raphe neurons.

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Authors: Mihailescu, S., Palomero-Rivero, M., Meade-Huerta, P., Maza-Flores, A., & Drucker-Colı́n, R.
Affiliations: Universidad Nacional Autónoma de México (MX)
Corresponding author: Drucker-Colı́n, René
ORCID: Mihailescu, Stefan
Venue: European Journal of Pharmacology
Publisher: Elsevier BV
Published: 1998-10
Volume: 360
Issue: 1
Pages: 31-36
ISSN: 0014-2999 (ISSN-L)
DOI: 10.1016/s0014-2999(98)00658-x
OpenAlex: W2031305942
Cited by: 117
References: 33
Citations by year: 2024: 3 · 2021: 1 · 2020: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 4 · 2013: 7 · 2012: 6
FWCI: 1.74
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: European Journal of Pharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: nicotine, mecamylamine, dorsal raphe nucleus, serotonin release, neuronal firing rate, nicotinic acetylcholine receptors, serotonergic neurotransmission, REM sleep suppression, mood improvement
MeSH terms: Action Potentials, Animals, Electrophysiology, Ganglionic Stimulants, Male, Mecamylamine, Neurons, Nicotine, Raphe Nuclei, Serotonin, Rats, Wistar, Nicotinic Antagonists, Rats, In Vitro Techniques

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Effects of nicotine and mecamylamine on rat dorsal raphe neurons

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