The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Effects of nicotine and mecamylamine on rat dorsal raphe neurons
Abstract
This study investigates the hypothesis that serotonin mediates certain nicotine effects, such as mood improvement and the suppression of the ponto-geniculo-occipital spikes of rapid eye movement sleep. The influence of nicotine (10-300 microM) on the firing rate of dorsal raphe neurons and on serotonin release was therefore, studied in rat midbrain slices. Nicotine increased the firing rate, 10-90%, in 67.5% recorded neurons and decreased it, 8-100%, in the remaining 32.5%. Serotonin release increased 2-7 times after nicotine administration, regardless of firing frequency, but the absolute value of serotonin release was 3 times higher during the decreases than during the increases in firing rate. Mecamylamine (1-20 microM) transiently stimulated the dorsal raphe neurons and competitively antagonized the nicotine-induced serotonin release. The results support the working hypothesis and additionally show that mecamylamine also stimulates dorsal raphe neurons.
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“Nicotine influences the rate of dorsal raphe nucleus (DRN) neuron firing, and can increase serotonin release in rat midbrain slices (Mihailescu et al., 1998), an effect that appears to be largely mediated by presynaptic enhancement of both norepinephrine (Li et al., 1998) and glutamate release (Garduno et al., 2012).”
From Mood and anxiety regulation by nicotinic acetylcholine receptors: A potential pathway to modulate aggression and related behavioral states (2015) · cites this paper as Mihailescu et al., 1998
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Metadata
- Authors
- Mihailescu, S., Palomero-Rivero, M., Meade-Huerta, P., Maza-Flores, A., & Drucker-Colı́n, R.
- Affiliations
- Universidad Nacional Autónoma de México (MX)
- Corresponding author
- Drucker-Colı́n, René
- ORCID
- Mihailescu, Stefan
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 1998-10
- Volume
- 360
- Issue
- 1
- Pages
- 31-36
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W2031305942
- Cited by
- 117
- References
- 33
- Citations by year
- 2024: 3 · 2021: 1 · 2020: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 4 · 2013: 7 · 2012: 6
- FWCI
- 1.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- nicotine, mecamylamine, dorsal raphe nucleus, serotonin release, neuronal firing rate, nicotinic acetylcholine receptors, serotonergic neurotransmission, REM sleep suppression, mood improvement
- MeSH terms
- Action Potentials, Animals, Electrophysiology, Ganglionic Stimulants, Male, Mecamylamine, Neurons, Nicotine, Raphe Nuclei, Serotonin, Rats, Wistar, Nicotinic Antagonists, Rats, In Vitro Techniques
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