Cited by 1,565HER2/EGFR in Cancer ResearchReceptor Mechanisms and SignalingProtein Kinase Regulation and GTPase Signaling

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Epidermal growth factor receptor: mechanisms of activation and signalling

Jorissen, R·2003·Experimental Cell Research

DOI 10.1016/s0014-4827(02)00098-8

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Abstract

The epidermal growth factor (EGF) receptor (EGFR) is one of four homologous transmembrane proteins that mediate the actions of a family of growth factors including EGF, transforming growth factor-alpha, and the neuregulins. We review the structure and function of the EGFR, from ligand binding to the initiation of intracellular signalling pathways that lead to changes in the biochemical state of the cell. The recent crystal structures of different domains from several members of the EGFR family have challenged our concepts of these processes.

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Authors: Jorissen, R.
Affiliations: The Royal Melbourne Hospital (AU)
Corresponding author: Jorissen, R
ORCID: Jorissen, R
Venue: Experimental Cell Research
Publisher: Elsevier BV
Published: 2003-03-10
Volume: 284
Issue: 1
Pages: 31-53
ISSN: 0014-4827 (ISSN-L)
DOI: 10.1016/s0014-4827(02)00098-8
OpenAlex: W2043911313
Cited by: 1,565
References: 291
Citations by year: 2026: 10 · 2025: 28 · 2024: 41 · 2023: 50 · 2022: 36 · 2021: 37 · 2020: 68 · 2019: 42 · 2018: 41 · 2017: 61 · 2016: 67 · 2015: 75 · 2014: 85 · 2013: 84 · 2012: 95
FWCI: 41.66
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Experimental Cell Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › HER2/EGFR in Cancer Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords: epidermal growth factor receptor, EGFR activation, receptor signaling, ligand binding, transforming growth factor-alpha, neuregulin, receptor tyrosine kinase, crystal structure, growth factor receptors
MeSH terms: Animals, Cell Movement, Humans, Models, Molecular, Protein Conformation, Transforming Growth Factors, Signal Transduction, ErbB Receptors

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Epidermal growth factor receptor: mechanisms of activation and signalling

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