The DOI matches its Crossref record; 291 of the 291 references it cites were found in a registry or an index.
Epidermal growth factor receptor: mechanisms of activation and signalling
Abstract
The epidermal growth factor (EGF) receptor (EGFR) is one of four homologous transmembrane proteins that mediate the actions of a family of growth factors including EGF, transforming growth factor-alpha, and the neuregulins. We review the structure and function of the EGFR, from ligand binding to the initiation of intracellular signalling pathways that lead to changes in the biochemical state of the cell. The recent crystal structures of different domains from several members of the EGFR family have challenged our concepts of these processes.
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“The EGFR pathway plays a crucial role in regulating the telomerase complex [215].”
From Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy (2024) · cites this paper as [215]
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Metadata
- Authors
- Jorissen, R.
- Affiliations
- The Royal Melbourne Hospital (AU)
- Corresponding author
- Jorissen, R
- ORCID
- Jorissen, R
- Venue
- Experimental Cell Research
- Publisher
- Elsevier BV
- Published
- 2003-03-10
- Volume
- 284
- Issue
- 1
- Pages
- 31-53
- ISSN
- 0014-4827 (ISSN-L)
- OpenAlex
- W2043911313
- Cited by
- 1,565
- References
- 291
- Citations by year
- 2026: 10 · 2025: 28 · 2024: 41 · 2023: 50 · 2022: 36 · 2021: 37 · 2020: 68 · 2019: 42 · 2018: 41 · 2017: 61 · 2016: 67 · 2015: 75 · 2014: 85 · 2013: 84 · 2012: 95
- FWCI
- 41.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Cell Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › HER2/EGFR in Cancer Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- epidermal growth factor receptor, EGFR activation, receptor signaling, ligand binding, transforming growth factor-alpha, neuregulin, receptor tyrosine kinase, crystal structure, growth factor receptors
- MeSH terms
- Animals, Cell Movement, Humans, Models, Molecular, Protein Conformation, Transforming Growth Factors, Signal Transduction, ErbB Receptors
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