The DOI matches its Crossref record; 291 of the 291 references it cites were found in a registry or an index.
Epidermal growth factor receptor: mechanisms of activation and signalling
Abstract
The epidermal growth factor (EGF) receptor (EGFR) is one of four homologous transmembrane proteins that mediate the actions of a family of growth factors including EGF, transforming growth factor-alpha, and the neuregulins. We review the structure and function of the EGFR, from ligand binding to the initiation of intracellular signalling pathways that lead to changes in the biochemical state of the cell. The recent crystal structures of different domains from several members of the EGFR family have challenged our concepts of these processes.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The EGFR pathway plays a crucial role in regulating the telomerase complex [215].”
From Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy (2024) · cites this paper as [215]
Citations
Cites
MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures
Kraulis, P. J. (1991) · Journal of Applied Crystallography · doi:10.1107/s0021889891004399 · Cited by 14,011
Untangling the ErbB signalling network
Yarden, Y., & Sliwkowski, M. X. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35052073 · Cited by 6,974
Rho GTPases and the Actin Cytoskeleton
Hall, A. (1998) · Science · doi:10.1126/science.279.5350.509 · Cited by 6,138
The phosphoinositide 3-kinase pathway
Cantley, L. C. (2002) · Science · doi:10.1126/science.296.5573.1655 · Cited by 5,621
Darnell, J. E. (1997) · Science · doi:10.1126/science.277.5332.1630 · Cited by 3,979
Cell Migration: A Physically Integrated Molecular Process
Lauffenburger, D. A., & Horwitz, A. F. (1996) · Cell · doi:10.1016/s0092-8674(00)81280-5 · Cited by 3,915
[26] Raster3D: Photorealistic molecular graphics
Merritt, E. A., & Bacon, D. (1997) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(97)77028-9 · Cited by 3,749
Ullrich, A., Coussens, L. M., Hayflick, J. S., Dull, T. J., Gray, A., Tam, A. W., Lee, J., Yarden, Y., Libermann, T. A., Schlessinger, J., et al. (1984) · Nature · doi:10.1038/309418a0 · Cited by 2,751
The ErbB signaling network: receptor heterodimerization in development and cancer
Olayioye, M. A., Neve, R. M., Lane, H. A., & Hynes, N. E. (2000) · The EMBO Journal · doi:10.1093/emboj/19.13.3159 · Cited by 2,489
Cohen, S. (1962) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)83739-0 · Cited by 2,202
The Conformational Plasticity of Protein Kinases
Huse, M., & Kuriyan, J. (2002) · Cell · doi:10.1016/s0092-8674(02)00741-9 · Cited by 1,760
The protein kinase B/Akt signalling pathway in human malignancy
Nicholson, K. M., & Anderson, N. G. (2002) · Cellular Signalling · doi:10.1016/s0898-6568(01)00271-6 · Cited by 1,665
The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling
Lowenstein, E. J., Daly, R. J., Batzer, A., Li, W., Margolis, B. L., Lammers, R., Ullrich, A., Skolnik, E. Y., Bar‐Sagi, D., & Schlessinger, J. (1992) · Cell · doi:10.1016/0092-8674(92)90167-b · Cited by 1,632
Carpenter, G., & Cohen, S. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38983-5 · Cited by 1,626
Graus-Porta, D., Beerli, R. R., Daly, J. M., & Hynes, N. E. (1997) · The EMBO Journal · doi:10.1093/emboj/16.7.1647 · Cited by 1,617
Stamos, J. L., Sliwkowski, M. X., & Eigenbrot, C. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207135200 · Cited by 1,594
Actin-Based Cell Motility and Cell Locomotion
Mitchison, T. J., & Cramer, L. P. (1996) · Cell · doi:10.1016/s0092-8674(00)81281-7 · Cited by 1,538
Rho GTPases Control Polarity, Protrusion, and Adhesion during Cell Movement
Nobes, C. D., & Hall, A. K. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.144.6.1235 · Cited by 1,450
Growth factors from murine sarcoma virus-transformed cells.
Larco, J. E. D., & Todaro, G. J. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.8.4001 · Cited by 1,446
Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness
Palecek, S. P., Loftus, J. C., Ginsberg, M. H., Lauffenburger, D. A., & Horwitz, A. F. (1997) · Nature · doi:10.1038/385537a0 · Cited by 1,427
Carpenter, G., & Cohen, S. (1976) · The Journal of Cell Biology · doi:10.1083/jcb.71.1.159 · Cited by 1,291
Regulation of Cell Motility by Mitogen-activated Protein Kinase
Klemke, R. L., Cai, S., Giannini, A. L. M., Gallagher, P. J., de Lanerolle, P., & Cheresh, D. A. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.137.2.481 · Cited by 1,239
Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains
Ogiso, H., Ishitani, R., Nureki, O., Fukai, S., Yamanaka, M., Kim, J.-H., Saito, K., Sakamoto, A., Inoue, M., Shirouzu, M., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)00963-7 · Cited by 1,227
Signaling through focal adhesion kinase
Schlaepfer, D. D., Hauck, C. R., & Sieg, D. J. (1999) · Progress in Biophysics and Molecular Biology · doi:10.1016/s0079-6107(98)00052-2 · Cited by 1,181
Targeted Disruption of Mouse EGF receptor: Effect of Genetic Background on Mutant Phenotype
Threadgill, D. W., Dlugosz, A. A., Hansen, L. A., Tennenbaum, T., Lichti, U., Yee, D., LaMantia, C., Mourton, T., Herrup, K., Harris, R. C., et al. (1995) · Science · doi:10.1126/science.7618084 · Cited by 1,179
Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor
Miettinen, P. J., Berger, J. E., Meneses, J. J., Phung, Y. T., Pedersen, R. A., Werb, Z., & Derynck, R. (1995) · Nature · doi:10.1038/376337a0 · Cited by 1,038
Strain-Dependent Epithelial Defects in Mice Lacking the EGF Receptor
Sibilia, M., & Wagner, E. F. (1995) · Science · doi:10.1126/science.7618085 · Cited by 1,002
The Role of Phosphoinositide 3-Kinase Lipid Products in Cell Function
Rameh, L. E., & Cantley, L. C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.13.8347 · Cited by 989
Hubbard, S. R. (1997) · The EMBO Journal · doi:10.1093/emboj/16.18.5572 · Cited by 959
A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity.
Nishikawa, R., Ji, X.-D., Harmon, R. C., Lazar, C. S., Gill, G. N., Cavenee, W. K., & Huang, H. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.16.7727 · Cited by 936
Single-molecule imaging of EGFR signalling on the surface of living cells
Sako, Y., Minoghchi, S., & Yanagida, T. (2000) · Nature Cell Biology · doi:10.1038/35004044 · Cited by 889
Han, J., Luby‐Phelps, K., Das, B., Shu, X., Xia, Y., Mosteller, R. D., Krishna, U. M., Falck, J. R., White, M. A., & Broek, D. (1998) · Science · doi:10.1126/science.279.5350.558 · Cited by 792
Garrett, T., McKern, N. M., Lou, M., ELLEMAN, T. C., Adams, T. E., Lovrecz, G. O., Zhu, H., Walker, F., Frenkel, M. J., Hoyne, P. A., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)00940-6 · Cited by 783
Self-citationA native 170,000 epidermal growth factor receptor-kinase complex from shed plasma membrane vesicles.
Cohen, S., Ushiro, H., Stoscheck, C. M., & Chinkers, M. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)68224-4 · Cited by 776
Bidirectional signaling between the cytoskeleton and integrins
Schoenwaelder, S. M., & Burridge, K. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)80037-4 · Cited by 762
Isolation and structure of urogastrone and its relationship to epidermal growth factor
Gregory, H. (1975) · Nature · doi:10.1038/257325a0 · Cited by 757
Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K
Keely, P. J., Westwick, J. K., Whitehead, I. P., Der, C. J., & Parise, L. V. (1997) · Nature · doi:10.1038/37656 · Cited by 732
Signalling through phosphoinositide 3-kinases: the lipids take centre stage
Leevers, S. J., Vanhaesebroeck, B., & Waterfield, M. D. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)80029-5 · Cited by 690
ErbB‐2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer.
Karunagaran, D., Tzahar, E., Beerli, R. R., Chen, X., Graus-Porta, D., Ratzkin, B. J., Seger, R., Hynes, N. E., & Yarden, Y. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00356.x · Cited by 674
Epidermal growth factor receptor and Ink4a/Arf
Bachoo, R. M., Maher, E. A., Ligon, K. L., Sharpless, N. E., Chan, S., You, M. J., Tang, Y., DeFrances, J., Stover, E. H., Weissleder, R., et al. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00046-6 · Cited by 659
TGFα deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice
Luetteke, N., Qiu, T. H., Peiffer, R. L., Oliver, P. M., Smithies, O., & Lee, D. C. (1993) · Cell · doi:10.1016/0092-8674(93)90228-i · Cited by 658
Biscardi, J. S., Maa, M.-C., Tice, D. A., Cox, M. E., Leu, T.-H., & Parsons, S. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.8335 · Cited by 649
Frequent expression of a mutant epidermal growth factor receptor in multiple human tumors.
Moscatello, D. K., Holgado-Madruga, M., Godwin, A. K., Ramirez, G., Gunn, G. R., Zoltick, P. W., Biegel, J. A., Hayes, R. L., & Wong, A. J. (1995) · PubMed · Cited by 637
Yarden, Y., & Schlessinger, J. (1987) · Biochemistry · doi:10.1021/bi00379a035 · Cited by 627
Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase γ
Pacold, M. E., Suire, S., Perišić, O., Lara‐González, S., Davis, C. T., Walker, E. H., Hawkins, P. T., Stephens, L., Eccleston, J. F., & Williams, R. L. (2000) · Cell · doi:10.1016/s0092-8674(00)00196-3 · Cited by 611
Epidermal growth factor receptors: critical mediators of multiple receptor pathways
Hackel, P. O., Zwick, E., Prenzel, N., & Ullrich, A. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)80024-6 · Cited by 604
Ekstrand, A. J., Sugawa, N., James, C. D., & Collins, V. P. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4309 · Cited by 601
Huang, H., Nagane, M., Klingbeil, C. K., Lin, H., Nishikawa, R., Ji, X.-D., Huang, C., Gill, G. N., Wiley, H. S., & Cavenee, W. K. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.5.2927 · Cited by 600
Sugawa, N., Ekstrand, A. J., James, C. D., & Collins, V. P. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.21.8602 · Cited by 594
Mann, G. B., Fowler, K. J., Gabriel, A., Nice, E. C., Williams, R. L., & Dunn, A. R. (1993) · Cell · doi:10.1016/0092-8674(93)90227-h · Cited by 583
Luetteke, N., Qiu, T. H., Fenton, S. E., Troyer, K. L., Riedel, R. F., Chang, A. Y., & Lee, D. C. (1999) · Development · doi:10.1242/dev.126.12.2739 · Cited by 570
Holland, E. C., Hively, W. P., DePinho, R. A., & Varmus, H. E. (1998) · Genes & Development · doi:10.1101/gad.12.23.3675 · Cited by 561
PDGF stimulates an increase in GTP–Rac via activation of phosphoinositide 3-kinase
Hawkins, P. T., Eguinoa, A., Qiu, R., Stokoe, D., Cooke, F. T., Walters, R. J., Wennström, S., Claesson, L., Evans, T., Symons, M. H., et al. (1995) · Current Biology · doi:10.1016/s0960-9822(95)00080-7 · Cited by 536
Jones, P. F., Jakubowicz, T., Pitossi, F. J., Maurer, F., & Hemmings, B. A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.10.4171 · Cited by 532
Yarden, Y., & Schlessinger, J. (1987) · Biochemistry · doi:10.1021/bi00379a034 · Cited by 506
Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation
Yamaguchi, H. Q., & Hendrickson, W. A. (1996) · Nature · doi:10.1038/384484a0 · Cited by 495
Näthke, I. S., Adams, C. L., Polakis, P. G., Sellin, J. H., & Nelson, W. J. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.134.1.165 · Cited by 484
Suppression of Integrin Activation: A Novel Function of a Ras/Raf-Initiated MAP Kinase Pathway
Hughes, P. E., Renshaw, M. W., Pfaff, M., Forsyth, J. S., Keivens, V. M., Schwartz, M. A., & Ginsberg, M. H. (1997) · Cell · doi:10.1016/s0092-8674(00)81892-9 · Cited by 481
Hierarchy of Binding Sites for Grb2 and Shc on the Epidermal Growth Factor Receptor
Batzer, A., Rotin, D., Ureña, J. M., Skolnik, E. Y., & Schlessinger, J. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.8.5192 · Cited by 479
Mechanism of biological synergy between cellular Src and epidermal growth factor receptor
Tice, D. A., Biscardi, J. S., Nickles, A. L., & Parsons, S. J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1415 · Cited by 472
Molecular diversity of cell-matrix adhesions
Zamir, E., Katz, B.-Z., Aota, S., Yamada, K. M., Geiger, B., & Kam, Z. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.11.1655 · Cited by 459
Cell migration: regulation of force on extracellular-matrix-integrin complexes
Sheetz, M. P., Felsenfeld, D. P., & Galbraith, C. G. (1998) · Trends in Cell Biology · doi:10.1016/s0962-8924(98)80005-6 · Cited by 452
Structure of the Extracellular Region of HER3 Reveals an Interdomain Tether
Cho, H., & Leahy, D. J. (2002) · Science · doi:10.1126/science.1074611 · Cited by 447
The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase.Preprint
Luetteke, N. C., Phillips, H. K., Qiu, T. H., Copeland, N. G., Earp, H. S., Jenkins, N. A., & Lee, D. C. (1994) · Genes & Development · doi:10.1101/gad.8.4.399 · Cited by 446
Requirement of Ras-GTP-Raf Complexes for Activation of Raf-1 by Protein Kinase C
Marais, R., Light, Y., Mason, C., Paterson, H., Olson, M. F., & Marshall, C. J. (1998) · Science · doi:10.1126/science.280.5360.109 · Cited by 441
Gadella, T. W. J., & Jovin, T. M. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.129.6.1543 · Cited by 438
Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling
Pouysségur, J., Volmat, V., & Lenormand, P. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01135-8 · Cited by 420
Shc and Fak Differentially Regulate Cell Motility and Directionality Modulated by Pten
Gu, J., Tamura, M., Pankov, R. G., Danen, E. H. J., Takino, T., Matsumoto, K., & Yamada, K. M. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.2.389 · Cited by 417
Lenferink, A. E. G., Pinkas‐Kramarski, R., van de Poll, M. L. M., van Vugt, M. J. H., Klapper, L. N., Tzahar, E., Waterman, H., Sela, M., van Zoelen, E. J. J., & Yarden, Y. (1998) · The EMBO Journal · doi:10.1093/emboj/17.12.3385 · Cited by 413
Vassar, R. J., & Fuchs, E. V. (1991) · Genes & Development · doi:10.1101/gad.5.5.714 · Cited by 411
Nagane, M., Coufal, F. J., Lin, H., Bögler, O., Cavenee, W. K., & Huang, H.-J. S. (1996) · PubMed · Cited by 405
Regulation of cell movement is mediated by stretch-activated calcium channels
Lee, J., Ishihara, A., Oxford, G. S., Johnson, B. D., & Jacobson, K. (1999) · Nature · doi:10.1038/22578 · Cited by 392
Regulation of Cell Migration by the Calcium-dependent Protease Calpain
Huttenlocher, A., Palecek, S. P., Lu, Q., Zhang, W., Mellgren, R. L., Lauffenburger, D. A., Ginsberg, M. H., & Horwitz, A. F. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.52.32719 · Cited by 390 · cited 4×
“, in situations where there is high substrate adhesiveness [249,251].”
BackgroundInfluentialCutting to the chase: calpain proteases in cell motility
Glading, A., Lauffenburger, D. A., & Wells, A. H. (2002) · Trends in Cell Biology · doi:10.1016/s0962-8924(01)02179-1 · Cited by 388
Binding specificities and affinities of egf domains for ErbB receptors
Jones, J. T., Akita, R. W., & Sliwkowski, M. X. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00283-5 · Cited by 387
Carpenter, C. L., Auger, K. R., Chanudhuri, M., Yoakim, M., Schaffhausen, B. S., Shoelson, S. E., & Cantley, L. C. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98375-4 · Cited by 384
Molecular mechanisms of nonmuscle myosin-II regulation
Bresnick, A. R. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)80004-0 · Cited by 377
ErbB Receptor-induced Activation of Stat Transcription Factors Is Mediated by Src Tyrosine Kinases
Olayioye, M. A., Beuvink, I., Horsch, K., Daly, J. M., & Hynes, N. E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.24.17209 · Cited by 373
Two EGF molecules contribute additively to stabilization of the EGFR dimer
Lemmon, M. A., Bu, Z., Ladbury, J. E., Zhou, M., Pinchasi, D., Lax, I., Engelman, D. M., & Schlessinger, J. (1997) · The EMBO Journal · doi:10.1093/emboj/16.2.281 · Cited by 368
Moriki, T., Maruyama, H., & MARUYAMA, I. N. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.4923 · Cited by 350
Multidrug resistance mediated by the ATP-binding cassette transporter protein MRP
Cole, S. P. C., & Deeley, R. G. (1998) · BioEssays · doi:10.1002/(sici)1521-1878(199811)20:11 · Cited by 342
Sequential protein kinase reactions controlling cell growth and differentiation
Johnson, G. L., & Vaillancourt, R. R. (1994) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(94)90141-4 · Cited by 336
Temporal and Spatial Regulation of Chemotaxis
Iijima, M., Huang, Y. E., & Devreotes, P. N. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00292-7 · Cited by 331
Maa, M. C., Leu, T. H., McCarley, D. J., Schatzman, R. C., & Parsons, S. J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.15.6981 · Cited by 330
Tumor Invasion: Role of Growth Factor-Induced Cell Motility
Wells, A. H. (1999) · Advances in cancer research · doi:10.1016/s0065-230x(08)61023-4 · Cited by 329
Aspenström, P. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)80011-8 · Cited by 326
EGF mutant receptor vIII as a molecular target in cancer therapy.
Kuan, C., Wikstrand, C. J., & Bigner, D. D. (2001) · Endocrine Related Cancer · doi:10.1677/erc.0.0080083 · Cited by 325
Chen, P., Xie, H., Sekar, M. C., Gupta, K. B., & Wells, A. H. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.127.3.847 · Cited by 324
Autoregulatory Mechanisms in Protein-tyrosine Kinases
Hubbard, S. R., Mohammadi, M., & Schlessinger, J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.20.11987 · Cited by 323
Tyrosine kinase receptor-activated signal transduction pathways which lead to oncogenesis
Porter, A. C., & Vaillancourt, R. R. (1998) · Oncogene · doi:10.1038/sj.onc.1202171 · Cited by 322
Regulated Migration of Epidermal Growth Factor Receptor from Caveolae
Mineo, C., Gill, G. N., & Anderson, R. G. W. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.43.30636 · Cited by 321
Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase
Harari, D., Tzahar, E., Romano, J., Shelly, M., Pierce, J., Andrews, G. C., & Yarden, Y. (1999) · Oncogene · doi:10.1038/sj.onc.1202631 · Cited by 318
Beerli, R. R., & Hynes, N. E. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.11.6071 · Cited by 308
Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src
Barone, M. V., & Courtneidge, S. A. (1995) · Nature · doi:10.1038/378509a0 · Cited by 308
Genetic alterations in breast cancer
Bièche, I., & Lidereau, R. (1995) · Genes Chromosomes and Cancer · doi:10.1002/gcc.2870140402 · Cited by 303
Beguinot, L., Lyall, R. M., Willingham, M. C., et al. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.8.2384 · Cited by 294
Regulation of MAP kinase activity by peptide receptor signalling pathway: Paradigms of multiplicity
Liebmann, C. (2001) · Cellular Signalling · doi:10.1016/s0898-6568(01)00192-9 · Cited by 291
Signaling by integrin receptors
Kumar, C. C. (1998) · Oncogene · doi:10.1038/sj.onc.1202172 · Cited by 288
Wiley, H. S., Herbst, J. J., Walsh, B. J., Lauffenburger, D. A., Rosenfeld, M. G., & Gill, G. N. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99131-3 · Cited by 287
Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone
Yamauchi, T., Ueki, K., Tobe, K., Tamemoto, H., Sekine, N., Wada, M., Honjo, M., Takahashi, M., Takahashi, T., Hirai, H., et al. (1997) · Nature · doi:10.1038/36369 · Cited by 284
Regulation of substrate adhesion dynamics during cell motility
Kaverina, I., Krylyshkina, O., & Small, J. V. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(01)00171-6 · Cited by 280
Epidermal‐Growth‐Factor‐Dependent Activation of the Src‐Family Kinases
Osherov, N., & Levitzki, A. (1994) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1994.1047b.x · Cited by 279
Endocytosis of growth factor receptors
Sorkin, A. D., & Waters, C. M. (1993) · BioEssays · doi:10.1002/bies.950150603 · Cited by 277
The Role of Tyrosine Phosphorylation of Cortactin in the Locomotion of Endothelial Cells
Huang, C., Liu, J., Haudenschild, C. C., & Zhan, X. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.40.25770 · Cited by 267
Wiesen, J. F., Young, P., Werb, Z., & Cunha, G. R. (1999) · Development · doi:10.1242/dev.126.2.335 · Cited by 265
Humphrey, P. A., Wong, A. J., Vogelstein, B., et al. (1988) · PubMed · Cited by 265
Chang, J. H., Gill, S. R., Settleman, J. E., & Parsons, S. J. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.130.2.355 · Cited by 256
Ekstrand, A. J., Longo, N., Hamid, M. L., Olson, J. J., Liu, L., Collins, V. P., & James, C. D. (1994) · PubMed · Cited by 255
Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor
Garrett, T., McKern, N. M., Lou, M., Frenkel, M. J., Bentley, J. D., Lovrecz, G. O., ELLEMAN, T. C., Cosgrove, L. J., & Ward, C. W. (1998) · Nature · doi:10.1038/28668 · Cited by 254
The EGF receptor is an actin-binding protein.
den Hartigh, J. C., Henegouwen, P. M. P. V. B. E., Verkleij, A. J., & Boonstra, J. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.119.2.349 · Cited by 247
Roche, S., Koegl, M., Barone, M. V., Roussel, M. F., & Courtneidge, S. A. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.2.1102 · Cited by 244
Karni, R., Jove, R., & Levitzki, A. (1999) · Oncogene · doi:10.1038/sj.onc.1202835 · Cited by 242
Zhao, M., Pu, J., Forrester, J. V., et al. (2002) · The FASEB Journal · doi:10.1096/fj.01-0811fje · Cited by 241
Murakami, H., Sanderson, N. D., Nagy, P., Marino, P. A., Merlino, G. T., & Thorgeirsson, S. S. (1993) · PubMed · Cited by 239
Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype.
Cook, P. W., Piepkorn, M. W., Clegg, C. H., Plowman, G. D., DeMay, J. M., Brown, J. R., & Pittelkow, M. R. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119766 · Cited by 231
Xie, H., Pallero, M. A., Gupta, K. B., Chang, P., Ware, M. F., Witke, W., Kwiatkowski, D. J., Lauffenburger, D. A., Murphy-Ullrich, J. E., & Wells, A. H. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.5.615 · Cited by 230
Epidermal growth factor receptor signaling
Bogdan, S., & Klämbt, C. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00167-1 · Cited by 227
Leaman, D. W., Pisharody, S., Flickinger, T. W., Commane, M., Schlessinger, J., Kerr, I. M., Levy, D. E., & Stark, G. R. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.1.369 · Cited by 226
Chen, P., Gupta, K. B., & Wells, A. H. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.124.4.547 · Cited by 226
Interaction of Ras and Raf in intact mammalian cells upon extracellular stimulation.
Hallberg, B., Rayter, S., & Downward, J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41718-2 · Cited by 225
Yu, X., Sharma, K. D., Takahashi, T., Iwamoto, R., & Mekada, E. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-08-0411 · Cited by 222
Role of Jak Kinases and STATs in Cytokine Signal Transduction
Leonard, W. J. (2001) · International Journal of Hematology · doi:10.1007/bf02981951 · Cited by 220
Cell–substrate interactions and signaling through ILK
Dedhar, S. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)00083-6 · Cited by 220
Structure-Function relationships for the EGF/TGF-α family of mitogens
Groenen, L. C., Nice, E. C., & Burgess, A. W. (1994) · Growth Factors · doi:10.3109/08977199409010997 · Cited by 218
Stover, D. R., Becker, M., Liebetanz, J., & Lydon, N. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.26.15591 · Cited by 218
Integrins and GTPases in tumour cell growth, motility and invasion
Keely, P. J., Parise, L. V., & Juliano, R. L. (1998) · Trends in Cell Biology · doi:10.1016/s0962-8924(97)01219-1 · Cited by 218
Fowler, K. J., Walker, F., Alexander, W. S., Hibbs, M. L., Nice, E. C., Böhmer, R. ‐., Mann, G. B., Thumwood, C. M., Maglitto, R., & Danks, J. A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.5.1465 · Cited by 217
van Leeuwen, F. N., van Delft, S., Kain, H. E. T., van der Kammen, R. A., & Collard, J. G. (1999) · Nature Cell Biology · doi:10.1038/12068 · Cited by 215
Yamazaki, H., Fukui, Y., Ueyama, Y., Tamaoki, N., Kawamoto, T., Taniguchi, S., & Shibuya, M. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.4.1816 · Cited by 211
Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction
Corvera, S. (1998) · Trends in Cell Biology · doi:10.1016/s0962-8924(98)01366-x · Cited by 206
Mechanism of epidermal growth factor receptor autophosphorylation and high-affinity binding.
Böni‐Schnetzler, M., & Pilch, P. F. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.22.7832 · Cited by 205
In vitro activation of Stat3 by epidermal growth factor receptor kinase
Park, O. K., Schaefer, T. S., & Nathans, D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13704 · Cited by 205
Schlegel, J., Merdes, A., Stumm, G., et al. (1994) · International Journal of Cancer · doi:10.1002/ijc.2910560114 · Cited by 203
Production of an Epidermal Growth Factor Receptor-Related Protein
Weber, W., Gill, G. N., & Spiess, J. (1984) · Science · doi:10.1126/science.6324343 · Cited by 202
Mao, W., Irby, R., Coppola, D., Fu, L., Wloch, M., Turner, J., Yu, H., Garcia, R., Jove, R., & Yeatman, T. J. (1997) · Oncogene · doi:10.1038/sj.onc.1201496 · Cited by 200 · cited 2×
“In A431 cells and in colon carcinoma cell lines, endogenous c-Src has constitutively elevated kinase activity, which is reduced to basal levels by the EGFR-specific kinase inhibitor AG1478 [146,147].”
BackgroundKim, H., Sierke, S. L., & Koland, J. G. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31455-2 · Cited by 197
Socs1 binds to multiple signalling proteins and suppresses Steel factor‐dependent proliferation
Sepulveda, P. D., Okkenhaug, K., Rose, J. L., Hawley, R. G., Dubreuil, P. C., & Rottapel, R. K. (1999) · The EMBO Journal · doi:10.1093/emboj/18.4.904 · Cited by 194
Walton, G. M., Chen, W. S., Rosenfeld, M. G., & Gill, G. N. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)40080-x · Cited by 192
Honegger, A., Kris, R., Ullrich, A., & Schlessinger, J. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.3.925 · Cited by 189
Langlois, W. J., Sasaoka, T., Saltiel, A. R., & Olefsky, J. M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.43.25320 · Cited by 187
Saito, Y., Haendeler, J., Hojo, Y., Yamamoto, K., & Berk, B. C. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.19.6387-6394.2001 · Cited by 180
Zhao, M., Dick, A. D., Forrester, J. V., & McCaig, C. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.4.1259 · Cited by 176
STAT Activation by Epidermal Growth Factor (EGF) and Amphiregulin
David, M., Wong, L., Flavell, R. A., Thompson, S. A., Wells, A. H., Larner, A. C., & Johnson, G. R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.16.9185 · Cited by 173
Cloning and Biological Activity of Epigen, a Novel Member of the Epidermal Growth Factor Superfamily
Strachan, L., Murison, J. G., Prestidge, R. L., Sleeman, M. A., Watson, J. D., & Kumble, K. D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006935200 · Cited by 171
Shoelson, S. E., Sivaraja, M., Williams, K. P., Hu, P. J., Schlessinger, J., & Weiss, M. A. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05714.x · Cited by 169
STAT5b, a Mediator of Synergism between c-Src and the Epidermal Growth Factor Receptor
Kloth, M. T., Laughlin, K. K., Biscardi, J. S., Boerner, J. L., Parsons, S. J., & Silva, C. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207289200 · Cited by 166
Mutations in the cytoplasmic domain of EGF receptor affect EGF binding and receptor internalization.
Prywes, R., Livneh, E., Ullrich, A., et al. (1986) · The EMBO Journal · doi:10.1002/j.1460-2075.1986.tb04482.x · Cited by 166
Tumor invasion as dysregulated cell motility
Kassis, J. N., Lauffenburger, D. A., Turner, T., & Wells, A. H. (2001) · Seminars in Cancer Biology · doi:10.1006/scbi.2000.0362 · Cited by 165
Fang, K. S., Ionides, E. L., OSTER, G. F., Nuccitelli, R., & Isseroff, R. R. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.12.1967 · Cited by 164
Keilhack, H., Tenev, T., Nyakatura, E., Godovac‐Zimmermann, J., Nielsen, L., Seedorf, K., & Böhmer, F. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.38.24839 · Cited by 160
Malden, L. T., Novak, U., Kaye, A. H., et al. (1988) · PubMed · Cited by 158
Malliri, A., Symons, M. H., Hennigan, R. F., Hurlstone, A. F. L., Lamb, R. F., Wheeler, T., & Ozanne, B. W. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.4.1087 · Cited by 155
Sandgren, E. P., Schroeder, J. A., Qui, T. H., Palmiter, R. D., Brinster, R. L., & Lee, D. C. (1995) · PubMed · Cited by 155
A role for gelsolin in actuating epidermal growth factor receptor-mediated cell motility.
Chen, P., Murphy-Ullrich, J. E., & Wells, A. H. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.134.3.689 · Cited by 155
Extracellular domains drive homo‐ but not hetero‐dimerization of erbB receptors
Ferguson, K. M., Darling, P. J., Mohan, M. J., Macatee, T. L., & Lemmon, M. A. (2000) · The EMBO Journal · doi:10.1093/emboj/19.17.4632 · Cited by 153
Am, D., Wang, X., King, L. E., Nanney, L., Ta, G., Sellheyer, K., Bundman, D. S., Longley, M., Rothnagel, J. A., & Da, G. (1993) · PubMed · Cited by 153
Chattopadhyay, A., Vecchi, M., Ji, Q.-S., Mernaugh, R. L., & Carpenter, G. F. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.37.26091 · Cited by 150
Verbeek, B. S., Adriaansen-slot, S. S., Feltkamp‐Vroom, T. M., Beckers, T. L., & Rijksen, G. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00224-5 · Cited by 150
Luttrell, D. K., Luttrell, L. M., & Parsons, S. J. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.1.497-501.1988 · Cited by 149
Ware, M. F., Wells, A. H., & Lauffenburger, D. A. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.16.2423 · Cited by 148
Slieker, L. J., Martensen, T. M., & Lane, M. D. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)66858-9 · Cited by 145
Lamaze, C., & Schmid, S. L. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.129.1.47 · Cited by 145
ErbB3 (HER3) interaction with the p85 regulatory subunit of phosphoinositide 3-kinase
Hellyer, N. J., Cheng, K., & Koland, J. G. (1998) · Biochemical Journal · doi:10.1042/bj3330757 · Cited by 144
Arteaga, C. L., Ramsey, T. T., Shawver, L. K., & Guyer, C. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.37.23247 · Cited by 143
Glycosylation-induced Conformational Modification Positively Regulates Receptor-Receptor Association
Fernandes, H., Cohen, S., & Bishayee, S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m005599200 · Cited by 142
Shiraha, H., Glading, A., Gupta, K. B., & Wells, A. H. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.1.243 · Cited by 142
Roof, R. W., Haskell, M. D., Dukes, B. D., Sherman, N. E., Kinter, M. T., & Parsons, S. J. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.12.7052 · Cited by 142
c-SRC Phosphorylates Epidermal Growth Factor Receptor on Tyrosine 845
Sato, K., Sato, A., Aoto, M., & Fukami, Y. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2574 · Cited by 139
Damelin, M. I., & Silver, P. A. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80409-8 · Cited by 139
Kendall, R. L., Rutledge, R. Z., Mao, X., Tebben, A. J., Hungate, R. W., & Thomas, K. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.10.6453 · Cited by 136
Sun, L., & Carpenter, G. F. (1998) · Oncogene · doi:10.1038/sj.onc.1201731 · Cited by 133
Honegger, A., Schmidt, A., Ullrich, A., & Schlessinger, J. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.8.4035 · Cited by 132
Wahl, M. I., Nishibe, S., Kim, J. W., Kim, H., Rhee, S. G., & Carpenter, G. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39685-1 · Cited by 132
Johns, T. G., Stockert, E., Ritter, G., et al. (2002) · International Journal of Cancer · doi:10.1002/ijc.10189 · Cited by 131
Restructuring of Focal Adhesion Plaques by Pi 3-Kinase
Greenwood, J. A., Theibert, A. B., Prestwich, G. D., et al. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.3.627 · Cited by 131
Constitutive phosphorylation of Shc proteins in human tumors.
Pelicci, P. G., Lanfrancone, L., Salcini, A. E., et al. (1995) · PubMed · Cited by 129
Xie, W., Paterson, A. J., Chin, E., Nabell, L. M., & Kudlow, J. E. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.12.0019 · Cited by 127
Xia, L., Wang, L., Chung, A. S., Ivanov, S. S., Ling, M. Y., Dragoi, A. M., Platt, A., Gilmer, T. M., Fu, X.-Y., & Chin, Y. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202823200 · Cited by 126
Gotoh, N., Tojo, A., Hino, M., Yazaki, Y., & Shibuya, M. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)90812-y · Cited by 126
Fukazawa, T., Miyake, S., Band, V., & Band, H. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.24.14554 · Cited by 125
The signaling pathway coupling epidermal growth factor receptors to activation of p21ras.
Sasaoka, T., Langlois, W. J., Leitner, J. W., Draznin, B., & Olefsky, J. M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31679-x · Cited by 123
Gotoh, N., Tojo, A., Muroya, K., Hashimoto, Y., Hattori, S., Nakamura, S., Takenawa, T., Yazaki, Y., & Shibuya, M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.1.167 · Cited by 123
Santoni‐Rugiu, E., Jensen, M. R., & Thorgeirsson, S. S. (1998) · PubMed · Cited by 123
Lichtner, R. B., Menrad, A., Sommer, A., Klar, U., & Schneider, M. R. (2001) · PubMed · Cited by 121
Binding of Zinc Finger Protein ZPR1 to the Epidermal Growth Factor Receptor
Galcheva-Gargova, Z., Konstantinov, K. N., Wu, I., Klier, F. G., Barrett, T., & Davis, R. J. (1996) · Science · doi:10.1126/science.272.5269.1797 · Cited by 119
Walker, F., Kato, A., Góñez, L. J., Hibbs, M. L., Pouliot, N., Levitzki, A., & Burgess, A. W. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.12.7192 · Cited by 118
Role of c-Src tyrosine kinase in EGF-induced mitogenesis
Parsons, S. J. (1997) · Frontiers in bioscience · doi:10.2741/a208 · Cited by 117
Slaaby, R., Jensen, T., Hansen, H. S., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.50.33722 · Cited by 117
Yamabhai, M., & Anderson, R. G. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200277200 · Cited by 116
Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2
Xu, X., Yi, T., Tang, B., & Lambeth, J. D. (1998) · Oncogene · doi:10.1038/sj.onc.1201678 · Cited by 116
Martin-Fernandez, M. L., Clarke, D. T., Tobin, M. J., Jones, S. V., & Jones, G. R. (2002) · Biophysical Journal · doi:10.1016/s0006-3495(02)75585-9 · Cited by 115
Jaks and stats in cytokine signaling
Ihle, J. N., Nosaka, T., Thierfelder, W. E., Quelle, F. W., & Shimoda, K. (1997) · Stem Cells · doi:10.1002/stem.5530150814 · Cited by 113
The human epidermal growth factor receptor contains a juxtamembrane calmodulin-binding site.
Kulaev, I. S., Konoshenko, G. I., & Umnov, A. M. (1972) · PubMed · doi:10.1021/bi971765v · Cited by 109
The mechanism involved in the regulation of phospholipase Cγ1 activity in cell migration
Piccolo, E., Innominato, P. F., Mariggiò, M. A., Maffucci, T., Iacobelli, S., & Falasca, M. (2002) · Oncogene · doi:10.1038/sj.onc.1205821 · Cited by 107
Sorokin, A., Lemmon, M. A., Ullrich, A., & Schlessinger, J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36947-8 · Cited by 103
Hurwitz, D. R., Emanuel, S. L., Nathan, M. H., Sarver, N., Ullrich, A., Felder, S., Lax, I., & Schlessinger, J. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54741-4 · Cited by 101
Okutani, T., Okabayashi, Y., Kido, Y., Sugimoto, Y., Sakaguchi, K., Matuoka, K., Takenawa, T., & Kasuga, M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47424-8 · Cited by 101
Blum, M. (1998) · Nature Neuroscience · doi:10.1038/1584 · Cited by 101
Milarski, K. L., Zhu, G., Pearl, C. G., et al. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49509-4 · Cited by 100
Cited by
Sorted by citations
Lynch, T. J., Bell, D. W., Sordella, R., Gurubhagavatula, S., Okimoto, R. A., Brannigan, B. W., Harris, P. L., Haserlat, S. M., Supko, J. G., Haluska, F. G., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040938 · Cited by 11,486
ErbB receptors and signaling pathways in cancer
Hynes, N. E., & MacDonald, G. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.12.010 · Cited by 956
The Epidermal Growth Factor Receptor Pathway: A Model for Targeted Therapy
Scaltriti, M., & Baselga, J. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1554 · Cited by 913
Linardou, H., Dahabreh, I. J., Kanaloupiti, D., Siannis, F., Bafaloukos, D., Kosmidis, P., Papadimitriou, C. A., & Murray, S. (2008) · The Lancet Oncology · doi:10.1016/s1470-2045(08)70206-7 · Cited by 739
Oncogenic Transformation by Inhibitor-Sensitive and -Resistant EGFR Mutants
Greulich, H., Chen, T.-H., Feng, W., Jänne, P. A., Alvarez, J. V., Zappaterra, M., Bulmer, S. E., Frank, D. A., Hahn, W. C., Sellers, W. R., et al. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0020313 · Cited by 677
Metadata
- Authors
- Jorissen, R.
- Affiliations
- The Royal Melbourne Hospital (AU)
- Corresponding author
- Jorissen, R
- ORCID
- Jorissen, R
- Venue
- Experimental Cell Research
- Publisher
- Elsevier BV
- Published
- 2003-03-10
- Volume
- 284
- Issue
- 1
- Pages
- 31-53
- ISSN
- 0014-4827 (ISSN-L)
- OpenAlex
- W2043911313
- Cited by
- 1,565
- References
- 291
- Citations by year
- 2026: 10 · 2025: 28 · 2024: 41 · 2023: 50 · 2022: 36 · 2021: 37 · 2020: 68 · 2019: 42 · 2018: 41 · 2017: 61 · 2016: 67 · 2015: 75 · 2014: 85 · 2013: 84 · 2012: 95
- FWCI
- 41.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Cell Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › HER2/EGFR in Cancer Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- epidermal growth factor receptor, EGFR activation, receptor signaling, ligand binding, transforming growth factor-alpha, neuregulin, receptor tyrosine kinase, crystal structure, growth factor receptors
- MeSH terms
- Animals, Cell Movement, Humans, Models, Molecular, Protein Conformation, Transforming Growth Factors, Signal Transduction, ErbB Receptors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review