Two organizational effects of pubertal testosterone in male rats: transient social memory and a shift away from long-term potentiation following a tetanus in hippocampal CA1
Abstract
The organizational role of pubertal androgen receptor (AR) activation in synaptic plasticity in hippocampal CA1 and in social memory was assessed. Earlier data suggest pubertal testosterone reduces adult hippocampal synaptic plasticity. Four groups were created following gonadectomy at the onset of puberty: rats given testosterone; rats given testosterone but with the AR antagonist flutamide, present during puberty; rats given testosterone at the end of puberty; and rats given cholesterol at the end of puberty. A tetanus normally inducing long-term potentiation (LTP) was used to stimulate CA1 in the urethane-anesthetized adults during the dark phase of their cycle. Social memory was assessed prior to electrophysiology. Social memory for a juvenile rat at 120 min was seen only in rats not exposed to AR activation during puberty. Pubertal AR activation may induce the reduced social memory of male rats. Early CA1 LTP occurred following tetanus in rats with no pubertal testosterone. Short-term potentiation occurred in rats exposed to pubertal testosterone. Unexpectedly, rats with pubertal AR activation developed long-term depression (LTD). The same pattern was seen in normal male rats. Lack of LTP during the dark phase is consistent with other data on circadian modulation of CA1 LTP. No correlations were seen among social memory scores and CA1 plasticity measures. These data argue for two organizational effects of pubertal testosterone: (1) CA1 synaptic plasticity shifts away fro…
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Androgens can reduce neuronal excitability in both adult and pubertal rodents.
“Intriguingly, androgens can reduce neuronal excitability in both adult (78) and pubertal rodents (79–81).”
From Sexual differentiation of neural mechanisms of stress sensitivity during puberty (2023) · cites this paper as [80]
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The neural basis of puberty and adolescence
Sisk, C. L., & Foster, D. L. (2004) · Nature Neuroscience · doi:10.1038/nn1326 · Cited by 1,085 · see citing works
Pubertal hormones organize the adolescent brain and behavior
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Sexual differentiation of neural mechanisms of stress sensitivity during puberty
Wright, E. C., Luo, P. X., Zakharenkov, H. C., Serna Godoy, A., Lake, A. A., Prince, Z. D., Sekar, S., Culkin, H. I., Ramirez, A. V., Dwyer, T., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2306475120 · Cited by 34 · see citing works
- Authors
- Hebbard, P. C., King, R. R., Malsbury, C. W., & Harley, C. W.
- Affiliations
- Memorial University of Newfoundland (CA)
- Corresponding author
- Harley, Carolyn W
- Venue
- Experimental Neurology
- Publisher
- Elsevier BV
- Published
- 2003-08
- Volume
- 182
- Issue
- 2
- Pages
- 470-475
- ISSN
- 0014-4886 (ISSN-L)
- OpenAlex
- W1987848336
- Cited by
- 60
- References
- 1
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2022: 3 · 2020: 3 · 2019: 3 · 2018: 6 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 1 · 2013: 3 · 2012: 3
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Keywords
- androgen receptor, social memory, long-term potentiation, long-term depression, short-term potentiation, hippocampal CA1, synaptic plasticity, gonadectomy, flutamide, cholesterol, circadian modulation, limbic circuits, male rats
- MeSH terms
- Androgen Antagonists, Animals, Behavior, Animal, Castration, Cholesterol, Electric Stimulation, Flutamide, Hippocampus, Male, Memory, Sexual Maturation, Social Behavior, Testosterone, Rats, Sprague-Dawley, Long-Term Potentiation, Excitatory Postsynaptic Potentials, Long-Term Synaptic Depression, Rats
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