CoChat
Sign Up
Cited by 139Fungal and yeast genetics researchRNA Research and SplicingNuclear Structure and Function

Inositol polyphosphate multikinase (ArgRIII) determines nuclear mRNA export in Saccharomyces cerevisiae

Saiardi, Adolfo, Caffrey, James J, Snyder, Solomon H, Shears, Stephen B·2000·FEBS Letters
DOI 10.1016/s0014-5793(00)01194-7
Open this paper in CoChat — free account

Abstract

The ARGRIII gene of Saccharomyces cerevisiae encodes a transcriptional regulator that also has inositol polyphosphate multikinase (ipmk) activity [Saiardi et al. (1999) Curr. Biol. 9, 1323–1326]. To investigate how inositol phosphates regulate gene expression, we disrupted the ARGRIII gene. This mutation impaired nuclear mRNA export, slowed cell growth, increased cellular [InsP 3] 170‐fold and decreased [InsP 6] 100‐fold, indicating reduced phosphorylation of InsP 3 to InsP 6. Levels of diphosphoinositol polyphosphates were decreased much less dramatically than was InsP 6. Low levels of InsP 6, and considerable quantities of Ins(1,3,4,5)P 4, were synthesized by an ipmk‐independent route. Transcriptional control by ipmk reflects that it is a pivotal regulator of nuclear mRNA export via inositol phosphate metabolism.

Integrity signals

Registry

Crossref · 10.1016/s0014-5793(00)01194-7

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • IPMK has roles in nutrient sensing, growth factor signaling, mRNA transport, and transcription regulation.

    “Initially identified in yeast and later recognized as essential for mammalian embryonic development, IPMK has transitioned from a niche interest to a focal point in studies of nutrient sensing, growth factor signaling, mRNA transport, and transcription regulation.”

    From From Obscurity to Prominence: IPMK’s Expanding Role in Cellular Signaling, Physiology, and Disease (2025) · cites this paper as [18]

  • IPMK functions in mRNA export, chromatin remodeling, transcription, nutrient sensing, and growth factor signaling.

    “Its diverse functions span a wide range of cellular processes, including mRNA export [17,18], chromatin remodeling [19,20], transcription [21,22], nutrient sensing [23], and growth factor signaling [15].”

    From From Obscurity to Prominence: IPMK’s Expanding Role in Cellular Signaling, Physiology, and Disease (2025) · cites this paper as [18]

Cited by

Sorted by citations

Authors
Saiardi, A., Caffrey, J. J., Snyder, S. H., & Shears, S. B.
Affiliations
  • Johns Hopkins University (US)
  • National Institutes of Health (US)
ORCID
Venue
FEBS Letters
Publisher
Wiley
Published
2000-02-14
Volume
468
Issue
1
Pages
28-32
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
DOI
10.1016/s0014-5793(00)01194-7
OpenAlex
W1983536335
Cited by
139
References
0
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 5 · 2014: 3 · 2013: 1 · 2012: 6
FWCI
5.31
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • FEBS Letters (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
  • National Institute of Mental Health (MH-18501)
  • National Institute on Drug Abuse (DA 00074)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Keywords
inositol polyphosphate multikinase, ArgR, mRNA export, inositol phosphate metabolism, phytic acid, inositol trisphosphate, transcriptional regulation, Saccharomyces cerevisiae, gene disruption, cell growth
MeSH terms
Biological Transport, Cell Division, Cell Nucleus, Chromatography, High Pressure Liquid, Fungal Proteins, Inositol Phosphates, Phosphorylation, Phytic Acid, RNA, Messenger, Saccharomyces cerevisiae, Signal Transduction, Inositol 1,4,5-Trisphosphate, Gene Expression Regulation, Fungal, Mutagenesis, Site-Directed, Gene Deletion, Phosphotransferases (Alcohol Group Acceptor), Saccharomyces cerevisiae Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review