The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization
Open accessAbstract
The function of the transcription regulator ArgRIII in the expression of several genes involved in the metabolism of arginine in yeast has been well studied. It was previously reported that it is also an inositol phosphate multikinase and an important factor of the mRNA export pathway [reviewed by Shears (2000) Bioessays 22, 786–789]. In the present study we report the cloning of a full-length 1248-bp cDNA encoding a human inositol phosphate multikinase (IPMK). This protein has a calculated molecular mass of 47.219kDa. Functionally important motifs [inositol phosphate-binding site, ATP-binding site, catalytically important SSLL (Ser-Ser-Leu-Leu) domain] are conserved between the human IPMK and yeast ArgRIII. Bacterially expressed protein demonstrated an inositol phosphate multikinase activity similar to that of yeast ArgRIII. Ins(1,4,5)P3 is phosphorylated at positions 3 and 6 up to Ins(1,3,4,5,6)P5. The human IPMK fused with a fluorescent protein tag is localized predominantly in the nucleus when transiently expressed in mammalian cells. A basic cluster in the protein's C-terminus is positively involved in nuclear targeting. These findings are consistent with the concept of a nuclear inositol phosphate signalling and phosphorylation pathway in mammalian cells.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Cites
Back in the Water: The Return of the Inositol Phosphates
Irvine, R. F., & Schell, M. J. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35073015 · Cited by 659 · see citing works
Wang, W., & Malcolm, B. A. (1999) · BioTechniques · doi:10.2144/99264st03 · Cited by 605 · see citing works
York, J. D., John, A. R. O., Murphy, R., Ives, E. B., & Wente, S. R. (1999) · Science · doi:10.1126/science.285.5424.96 · Cited by 547 · see citing works
Saiardi, A., Erdjument-Bromage, H., Snowman, A. M., Tempst, P., & Snyder, S. H. (1999) · Current Biology · doi:10.1016/s0960-9822(00)80055-x · Cited by 414 · see citing works
Fontes, M. R. M., Teh, T., & Kobe, B. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.3642 · Cited by 398 · see citing works
A Role for Nuclear Inositol 1,4,5-Trisphosphate Kinase in Transcriptional Control
Odom, A. R., Stahlberg, A., Wente, S. R., & York, J. D. (2000) · Science · doi:10.1126/science.287.5460.2026 · Cited by 394 · see citing works
Identification of the Human c- myc Protein Nuclear Translocation Signal
Dang, C. V., & Lee, W. M. F. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.10.4048-4054.1988 · Cited by 304 · see citing works
Larco, J. E. D., & Todaro, G. J. (1978) · Journal of Cellular Physiology · doi:10.1002/jcp.1040940311 · Cited by 296 · see citing works
Stephens, L., Radenberg, T., Thiel, U., Vogel, G., Khoo, K., Dell, A., Jackson, T., Hawkins, P. T., & Mayr, G. W. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53571-7 · Cited by 208 · see citing works
Self-citationMayr, G. W. (1988) · Biochemical Journal · doi:10.1042/bj2540585 · Cited by 197 · see citing works
Self-citationThe Inositol Hexakisphosphate Kinase Family
Saiardi, A., Caffrey, J. J., Snyder, S. H., & Shears, S. B. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002750200 · Cited by 180 · see citing works
Christophe, D., Christophe-Hobertus, C., & Pichon, B. (2000) · Cellular Signalling · doi:10.1016/s0898-6568(00)00077-2 · Cited by 165 · see citing works
Morrison, B., Bauer, J. A., Kalvakolanu, D. V., & Lindner, D. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101161200 · Cited by 162 · see citing works
Identification and Characterization of a Novel Inositol Hexakisphosphate Kinase
Saiardi, A., Nagata, E., Luo, H. R., Snowman, A. M., & Snyder, S. H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106842200 · Cited by 159 · see citing works
Schell, M. J., Erneux, C., & Irvine, R. F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104101200 · Cited by 142 · see citing works
Saiardi, A., Caffrey, J. J., Snyder, S. H., & Shears, S. B. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01194-7 · Cited by 139 · see citing works
Saiardi, A., Nagata, E., Luo, H. R., Sawa, A., Luo, X., Snowman, A. M., & Snyder, S. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.041614598 · Cited by 110 · see citing works
Biochemical and Functional Characterization of Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinases
Ives, E. B., Nichols, J. D., Wente, S. R., & York, J. D. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007586200 · Cited by 100 · see citing works
Nuclear phospholipase C and signaling
Cocco, L., Martelli, A. M., Gilmour, R. S., Rhee, S. G., & Manzoli, F. A. (2001) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00169-4 · Cited by 93 · see citing works
Dubois, E. L., Dewaste, V., Erneux, C., & Messenguy, F. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)02318-8 · Cited by 62 · see citing works
Bakkoury, M. E., Dubois, E., & Messenguy, F. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.01665.x · Cited by 57 · see citing works
Bercy, J., Dubois, E. L., & Messenguy, F. (1987) · Gene · doi:10.1016/0378-1119(87)90287-3 · Cited by 51 · see citing works
Guse, A. H., Goldwich, A., Weber, K., & Mayr, G. W. (1995) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/0378-4347(95)00219-9 · Cited by 48 · see citing works
Self-citationAmar, N., Messenguy, F., Bakkoury, M. E., & Dubois, E. L. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.6.2087-2097.2000 · Cited by 47 · see citing works
Nuclear Cotransport Mechanism of Cytoplasmic Human MxB Protein
Melén, K., & Julkunen, I. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.51.32353 · Cited by 42 · see citing works
Zhang, T., Caffrey, J. J., & Shears, S. B. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02351-1 · Cited by 37 · see citing works
Soriano, S., Thomas, S., High, S., Griffiths, G., D’Santos, C. S., Cullen, P. J., & Banting, G. S. (1997) · Biochemical Journal · doi:10.1042/bj3240579 · Cited by 35 · see citing works
Bertsch, U., Haefs, M., Möller, M., Deschermeier, C., Fanick, W., Kitzerow, A., Ozaki, S., Meyer, H. E., & Mayr, G. W. (1999) · Gene · doi:10.1016/s0378-1119(99)00018-9 · Cited by 22 · see citing works
Self-citationTwo nuclear localization signals are required for nuclear translocation of nuclear factor 1‐A
Imagawa, M., Sakaue, R., Tanabe, A., Osada, S., & Nishihara, T. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)02119-0 · Cited by 18 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Structure of Hdac3 Bound to Co-Repressor and Inositol Tetraphosphate
Watson, P. J., Fairall, L., Santos, G. M., & Schwabe, J. W. R. (2012) · Nature · doi:10.1038/nature10728 · Cited by 505 · see citing works
A Plasmodium falciparum Histone Deacetylase Regulates Antigenic Variation and Gametocyte Conversion
Coleman, B. I., Skillman, K. M., Jiang, R. H. Y., Childs, L. M., Altenhofen, L. M., Ganter, M., Leung, Y., Goldowitz, I., Kafsack, B. F. C., Marti, M., et al. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.06.014 · Cited by 235 · see citing works
Nuclear localization of enhanced green fluorescent protein homomultimers
Seibel, N. M., Eljouni, J., Nalaskowski, M. M., & Hampe, W. (2007) · Analytical Biochemistry · doi:10.1016/j.ab.2007.05.025 · Cited by 207 · see citing works
Self-citationHow versatile are inositol phosphate kinases?
Shears, S. B. (2004) · Biochemical Journal · doi:10.1042/bj20031428 · Cited by 173 · see citing works
Inositol pyrophosphates: metabolism and signaling
Bennett, M., Onnebo, S. M. N., Azevedo, C., & Saiardi, A. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5446-z · Cited by 173 · see citing works
Regulation of nuclear processes by inositol polyphosphates
York, J. D. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.04.014 · Cited by 168 · see citing works
Tsui, M. M. K., & York, J. D. (2009) · Advances in Enzyme Regulation · doi:10.1016/j.advenzreg.2009.12.002 · Cited by 162 · see citing works
Amino Acid Signaling to MTOR Mediated by Inositol Polyphosphate Multikinase
Kim, S., Kim, S. F., Maag, D., Maxwell, M. J., Resnick, A. C., Juluri, K. R., Chakraborty, A., Koldobskiy, M. A., Cha, S. H., Barrow, R., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.007 · Cited by 144 · see citing works
Frederick, J. P., Mattiske, D., Wofford, J. A., Megosh, L. C., Drake, L. Y., Chiou, S.-T., Hogan, B. L. M., & York, J. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503706102 · Cited by 139 · see citing works
Molecular and Biochemical Characterization of Two Plant Inositol Polyphosphate 6-/3-/5-Kinases
Stevenson, J. M., John, A. R. O., & York, J. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209112200 · Cited by 136 · see citing works
Inositol Hexakisphosphate Kinase Products Contain Diphosphate and Triphosphate Groups
Draškovič, P., Saiardi, A., Bhandari, R., Burton, A., Ilc, G., Kovačević, M., Snyder, S. H., & Podobnik, M. (2008) · Chemistry & Biology · doi:10.1016/j.chembiol.2008.01.011 · Cited by 126 · see citing works
Inositol Polyphosphate Multikinase Is a Physiologic PI3-Kinase That Activates Akt/PKB
Maag, D., Maxwell, M. J., Hardesty, D. A., Boucher, K. L., Choudhari, N., Hanno, A. G., Ma, J. F., Snowman, A. S., Pietropaoli, J. W., Xu, R., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1017831108 · Cited by 122 · see citing works
Sei, Y., Zhao, X., Forbes, J., Szymczak, S., Li, Q., Trivedi, A., Voellinger, M., Joy, G., Feng, J., Whatley, M., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.04.008 · Cited by 119 · see citing works
Inositol Polyphosphate Multikinase Is a Nuclear PI3-Kinase with Transcriptional Regulatory Activity
Resnick, A. C., Snowman, A. M., Kang, B. N., Hurt, K. J., Snyder, S. H., & Saiardi, A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506184102 · Cited by 119 · see citing works
Inositol phosphate synthesis and the nuclear processes they affect
Monserrate, J. P., & York, J. D. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.03.006 · Cited by 101 · see citing works
A Molecular Basis for Inositol Polyphosphate Synthesis in Drosophila melanogaster
Seeds, A. M., Sandquist, J. C., Spana, E. P., & York, J. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408295200 · Cited by 89 · see citing works
Inositol 1,4,5-trisphosphate 3-kinases: functions and regulations
Xia, H., & Yang, G. (2005) · Cell Research · doi:10.1038/sj.cr.7290270 · Cited by 83 · see citing works
Regulation of immune cell development through soluble inositol-1,3,4,5-tetrakisphosphate
Sauer, K., & Cooke, M. P. (2010) · Nature reviews. Immunology · doi:10.1038/nri2745 · Cited by 80 · see citing works
The Pathway for the Production of Inositol Hexakisphosphate in Human Cells
Verbsky, J. W., Chang, S., Wilson, M. P., Mochizuki, Y., & Majerus, P. W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411528200 · Cited by 80 · see citing works
Nuclear inositides: facts and perspectives
Martelli, A. M., Manzoli, L., & Cocco, L. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2003.10.003 · Cited by 79 · see citing works
Mayr, G. W., Windhorst, S., & Hillemeier, K. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500545200 · Cited by 73 · see citing works
Self-citationChang, S., Miller, A. L., Feng, Y., Wente, S. R., & Majerus, P. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206134200 · Cited by 74 · see citing works
Characterization of an Arabidopsis inositol 1,3,4,5,6-pentakisphosphate 2-kinase (AtIPK1)
Sweetman, D., Johnson, S., Caddick, S. E. K., Hanke, D. E., & Brearley, C. A. (2006) · Biochemical Journal · doi:10.1042/bj20051331 · Cited by 73 · see citing works
Jones, D. R., & Divecha, N. (2004) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2004.02.003 · Cited by 72 · see citing works
Nuclear PI(4,5)P2: A new place for an old signal
Bunce, M. W., Bergendahl, K., & Anderson, R. A. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.03.002 · Cited by 65 · see citing works
Seeds, A. M., Bastidas, R. J., & York, J. D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505089200 · Cited by 56 · see citing works
Otto, J. C., Kelly, P., Chiou, S., & York, J. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705729104 · Cited by 53 · see citing works
Stabilization of protein–protein interactions by small molecules
Giordanetto, F., Schäfer, A., & Ottmann, C. (2014) · Drug Discovery Today · doi:10.1016/j.drudis.2014.08.005 · Cited by 55 · see citing works
Windhorst, S., Lin, H., Blechner, C., Fanick, W., Brandt, L. T. L., Brehm, M. A., & Mayr, G. W. (2012) · Biochemical Journal · doi:10.1042/bj20121524 · Cited by 53 · see citing works
Self-citationMorgan-Lappe, S. E., Woods, K. W., Li, Q., Anderson, M. G., Schurdak, M. E., Luo, Y., Giranda, V. L., Fesik, S. W., & Leverson, J. D. (2005) · Oncogene · doi:10.1038/sj.onc.1209169 · Cited by 53 · see citing works
Fujii, M., & York, J. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m412006200 · Cited by 54 · see citing works
Crystal Structure of Inositol Phosphate Multikinase 2 and Implications for Substrate Specificity
Holmes, W., & Jogl, G. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606883200 · Cited by 51 · see citing works
Direct Activation of Human MLKL by a Select Repertoire of Inositol Phosphate Metabolites
McNamara, D. E., Dovey, C. M., Hale, A. T., Quarato, G., Grace, C. R., Guibao, C. D., Diep, J., Nourse, A., Cai, C., Wu, H., et al. (2019) · Cell chemical biology · doi:10.1016/j.chembiol.2019.03.010 · Cited by 51 · see citing works
Gokhale, N., Zaremba, A., & Shears, S. B. (2011) · Biochemical Journal · doi:10.1042/bj20101437 · Cited by 49 · see citing works
Wundenberg, T., Grabinski, N., Lin, H., & Mayr, G. W. (2014) · Biochemical Journal · doi:10.1042/bj20130992 · Cited by 49 · see citing works
Self-citationFu, P., Ebenezer, D. L., Ha, A. W., Suryadevara, V., Harijith, A. K., & Natarajan, V. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26707 · Cited by 49 · see citing works
Inositol Polyphosphate Multikinase Is a Coactivator of P53-Mediated Transcription and Cell Death
Xu, R., Sen, N., Paul, B. D., Snowman, A. M., Rao, F., Vandiver, M. S., Xu, J., & Snyder, S. H. (2013) · Science Signaling · doi:10.1126/scisignal.2003405 · Cited by 52 · see citing works
Shears, S. B., & Wang, H. (2018) · Advances in Biological Regulation · doi:10.1016/j.jbior.2018.10.006 · Cited by 42 · see citing works
Defining Signal Transduction by Inositol Phosphates
Shears, S. B., Ganapathi, S. B., Gokhale, N., Schenk, T. M. H., Wang, H., Weaver, J. D., Zaremba, A., & Zhou, Y. (2012) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-3015-1_13 · Cited by 46 · see citing works
Intracellular localization of human Ins(1,3,4,5,6)P5 2-kinase
Brehm, M. A., Schenk, T. M. H., Zhou, X., Fanick, W., Lin, H., Windhorst, S., Nalaskowski, M. M., Kobras, M., Shears, S. B., & Mayr, G. W. (2007) · Biochemical Journal · doi:10.1042/bj20070382 · Cited by 45 · see citing works
Self-citationWang, H., & Shears, S. B. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.801845 · Cited by 41 · see citing works
Inositol Polyphosphate Multikinase: Metabolic Architect of Nuclear Inositides
Resnick, A. C. (2008) · Frontiers in Bioscience · doi:10.2741/2726 · Cited by 39 · see citing works
IPMK: A Versatile Regulator of Nuclear Signaling Events
Kim, E., Beon, J., Lee, S., Park, J., & Kim, S. (2016) · Advances in Biological Regulation · doi:10.1016/j.jbior.2015.11.005 · Cited by 39 · see citing works
Chemical tools for interrogating inositol pyrophosphate structure and function
Brown, N. W., Marmelstein, A. M., & Fiedler, D. (2016) · Chemical Society Reviews · doi:10.1039/c6cs00193a · Cited by 35 · see citing works
Cordeiro, C. D., Saiardi, A., & Docampo, R. (2017) · Molecular Microbiology · doi:10.1111/mmi.13766 · Cited by 36 · see citing works
Nalaskowski, M. M., Bertsch, U., Fanick, W., Stockebrand, M. C., Schmale, H., & Mayr, G. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211059200 · Cited by 35 · see citing works
Self-citationIdentification of the actin-binding domain of Ins(1,4,5)P3 3-kinase isoform B (IP3K-B)
Brehm, M. A., Schreiber, I., Bertsch, U., Wegner, A., & Mayr, G. W. (2004) · Biochemical Journal · doi:10.1042/bj20031751 · Cited by 32 · see citing works
Self-citationLeyman, A., Pouillon, V., Bostan, A., Schurmans, S., Erneux, C., & Pesesse, X. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.01.024 · Cited by 32 · see citing works
Nalaskowski, M. M., Fliegert, R., Olga, E., Brehm, M. A., Fanick, W., Windhorst, S., Lin, H., Giehler, S., Hein, J. B., Lin, Y., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.173062 · Cited by 30 · see citing works
Self-citationArginine Transcriptional Response Does Not Require Inositol Phosphate Synthesis
Bosch, D., & Saiardi, A. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.384255 · Cited by 29 · see citing works
Nuclear phosphoinositides and their roles in cell biology and disease
Martelli, A. M., Ognibene, A., Buontempo, F., Fini, M., Bressanin, D., Goto, K., McCubrey, J. A., Cocco, L., & Evangelisti, C. (2011) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2011.609530 · Cited by 29 · see citing works
Signaling through non-membrane nuclear phosphoinositide binding proteins in human health and disease
Bryant, J. M., & Blind, R. D. (2018) · Journal of Lipid Research · doi:10.1194/jlr.r088518 · Cited by 27 · see citing works
Genetic Control of Lithium Sensitivity and Regulation of Inositol Biosynthetic Genes
King, J., Keim, M., Teo, R., Weening, K., Kapur, M., McQuillan, K., Ryves, J., Rogers, B., Dalton, E. C., Williams, R. S. B., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011151 · Cited by 28 · see citing works
Fu, C., Tyagi, R., Chin, A. C., Rojas, T., Li, R.-J., Guha, P., Bernstein, I. A., Rao, F., Xu, R., Cha, J. Y., et al. (2018) · Circulation Research · doi:10.1161/circresaha.117.311983 · Cited by 28 · see citing works
Damstra‐Oddy, J., Warren, E. C., Perry, C. J., Desfougères, Y., Fitzpatrick, J.-M., Schaf, J., Costelloe, L., Hind, W. H., Downer, E. J., Saiardi, A., et al. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15351 · Cited by 24 · see citing works
Seeds, A. M., Frederick, J. P., Tsui, M. M. K., & York, J. D. (2007) · Advances in Enzyme Regulation · doi:10.1016/j.advenzreg.2006.12.019 · Cited by 24 · see citing works
Signalling Properties of Inositol Polyphosphates
Maffucci, T., & Falasca, M. (2020) · Molecules · doi:10.3390/molecules25225281 · Cited by 21 · see citing works
Regulation of Inositol 1,4,5-Trisphosphate 3-Kinases by Calcium and Localization in Cells
Lloyd-Burton, S. M., Yu, J. C. H., Irvine, R. F., & Schell, M. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610253200 · Cited by 21 · see citing works
Nalaskowski, M. M., Metzner, A., Brehm, M. A., Labiadh, S., Brauer, H., Grabinski, N., Mayr, G. W., & Jücker, M. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.07.012 · Cited by 20 · see citing works
Self-citationErneux, C., Ghosh, S., & Koenig, S. (2015) · Advances in Biological Regulation · doi:10.1016/j.jbior.2015.09.004 · Cited by 18 · see citing works
Inositol polyphosphate multikinase regulates inositol 1,4,5,6-tetrakisphosphate
Chang, S., & Majerus, P. W. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.10.201 · Cited by 16 · see citing works
Gene transcription by p53 requires inositol polyphosphate multikinase as a co-activator
Xu, R., & Snyder, S. H. (2013) · Cell Cycle · doi:10.4161/cc.25119 · Cited by 15 · see citing works
A toolkit for graded expression of green fluorescent protein fusion proteins in mammalian cells
Nalaskowski, M. M., Ehm, P. A. H., Giehler, S., & Mayr, G. W. (2012) · Analytical Biochemistry · doi:10.1016/j.ab.2012.06.001 · Cited by 15 · see citing works
Self-citationNalaskowski, M. M., Ehm, P. A. H., Rehbach, C., Nelson, N., Täger, M., Modest, K., & Jücker, M. (2018) · Cellular Signalling · doi:10.1016/j.cellsig.2018.05.006 · Cited by 13 · see citing works
Self-citationA Class II Histone Deacetylase Acts on Newly Synthesized Histones in Tetrahymena
Smith, J. J., Torigoe, S. E., Maxson, J. E., Fish, L., & Wiley, E. A. (2008) · Eukaryotic Cell · doi:10.1128/ec.00409-07 · Cited by 13 · see citing works
Riley, A. M., Deleu, S., Qian, X., Mitchell, J. L., Chung, S., Adelt, S., Vogel, G., Potter, B. V. L., & Shears, S. B. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.12.016 · Cited by 13 · see citing works
Nalaskowski, M. M., Windhorst, S., Stockebrand, M. C., & Mayr, G. W. (2006) · Biological Chemistry · doi:10.1515/bc.2006.075 · Cited by 12 · see citing works
Self-citationCaddick, S. E. K., Harrison, C. J., Stavridou, I., Johnson, S., & Brearley, C. A. (2007) · Biochemical Journal · doi:10.1042/bj20061772 · Cited by 12 · see citing works
Liu, X., Moody, E. C., Hecht, S. S., & Sturla, S. J. (2007) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2007.10.032 · Cited by 11 · see citing works
Kublun, I., Ehm, P. A. H., Brehm, M. A., & Nalaskowski, M. M. (2014) · Biochimie · doi:10.1016/j.biochi.2014.03.001 · Cited by 10 · see citing works
Self-citationBiochemical Analysis of Inositol Phosphate Kinases
Otto, J. C., Mulugu, S., Fridy, P. C., Chiou, S., Armbruster, B. N., Ribeiro, A. A., & York, J. D. (2007) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(07)34010-x · Cited by 9 · see citing works
Design, Synthesis, and Cellular Characterization of a New Class of IPMK Kinase Inhibitors
Zhou, Y., Chapagain, P., Desmarini, D., Uredi, D., Stashko, M. A., Huluka, H., Rameh, L. E., Djordjevic, J. T., Blind, R. D., & Wang, X. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c00015 · Cited by 7 · see citing works
Desmarini, D., Liu, G., Jessen, H. J., Bowring, B. G., Connolly, A. M., Crossett, B., & Djordjevic, J. T. (2024) · mBio · doi:10.1128/mbio.00608-24 · Cited by 7 · see citing works
Böhm, J., Thavaraja, R., Giehler, S., & Nalaskowski, M. M. (2017) · Analytical Biochemistry · doi:10.1016/j.ab.2017.06.015 · Cited by 7 · see citing works
Self-citationOtto, J. C., & York, J. D. (2010) · Methods in molecular biology · doi:10.1007/978-1-60327-175-2_3 · Cited by 5 · see citing works
Desmarini, D., Truong, D., Wilkinson‐White, L. E., Deshpande, C. N., Torrado, M., Mackay, J. P., Matthews, J. M., Sorrell, T. C., Lev, S., Thompson, P. E., et al. (2022) · Biomolecules · doi:10.3390/biom12101526 · Cited by 5 · see citing works
Inositol Phosphates and Retroviral Assembly: A Cellular Perspective
Ricana, C. L., & Dick, R. A. (2021) · Viruses · doi:10.3390/v13122516 · Cited by 5 · see citing works
A Plasmodium multi-domain protein possesses multiple inositol phosphate kinase activities
Stritzke, C., Nalaskowski, M. M., Fanick, W., Lin, H., & Mayr, G. W. (2012) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2012.10.005 · Cited by 5 · see citing works
Self-citationDivecha, N. (2016) · Biochemical Society Transactions · doi:10.1042/bst20150238 · Cited by 4 · see citing works
Ins(1,3,4,5,6)P5: A Signal Transduction Hub
Shears, S. B. (2003) · Elsevier eBooks · doi:10.1016/b978-012124546-7/50521-0 · Cited by 3 · see citing works
Zweifel, A., Giehler, S., & Nalaskowski, M. M. (2019) · Analytical Biochemistry · doi:10.1016/j.ab.2019.113430 · Cited by 2 · see citing works
Self-citationSagadiev, S., Hudson, R., Wang, Y., Christmon, J., Reedy, A. R., Qadota, H., & Benian, G. M. (2026) · Genetics · doi:10.1093/genetics/iyag048 · Cited by 1 · see citing works
IPMK-1 governs C. elegans physiology through ceTOR but lifespan via a distinct IP3-dependent pathway
He, X.-X., Huang, Q., Yu, X., Shi, L., Ou, L., Wu, G.-S., & Luo, H. (2026) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2026.112179 · Cited by 1 · see citing works
Structural Studies of Arabidopsis Thaliana Inositol Polyphosphate Multi-Kinase
Endo-Streeter, S. (2009) · DukeSpace (Duke University)
Intrazelluläre Zielsteuerung der humanen Inositol-1,4,5-trisphosphat 3-Kinase Isoform B
Mayr, G. W. (2011)
Self-citationReview Inositol pyrophosphates: metabolism and signaling
Bennett, M. C., Onnebo, S. M. N., Azevedo, C., & Saiardi, A. (2006)
A novel 6-pyrophosphorylating IP6 kinase (IP6-6K) discovered in the protozoon Trichomonas vaginalis
Wundenberg, T., Nalaskowski, M. M., Löser, B., Fanick, W., Hackl, T., Fürnkranz, U., Rehbach, C., Lin, H., & Mayr, G. W. (2018) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2018.12.004
Self-citationLiu, X. (2009) · University of Minnesota Digital Conservancy (University of Minnesota)
Ramazzotti, G. (2008) · AMS Dottorato Institutional Doctoral Theses Repository (University of Bologna) · doi:10.6092/unibo/amsdottorato/1074
- Authors
- NALASKOWSKI, M. M., DESCHERMEIER, C., FANICK, W., & MAYR, G. W.
- Affiliations
- University Medical Center Hamburg-Eppendorf (DE)
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 2002-09-01
- Volume
- 366
- Issue
- 2
- Pages
- 549-556
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- PMC
- PMC1222796
- OpenAlex
- W1994071091
- Cited by
- 89
- References
- 29
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 5 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 4 · 2013: 2 · 2012: 6
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biochemical Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- cDNA cloning, inositol trisphosphate, inositol pentakisphosphate, nuclear localization, mRNA export
- MeSH terms
- Amino Acid Sequence, Animals, Arginine, Base Sequence, Binding Sites, Cell Line, Cell Nucleus, Cloning, Molecular, Fungal Proteins, Humans, Inositol Phosphates, Kidney, Molecular Sequence Data, Recombinant Proteins, Transfection, Polymerase Chain Reaction, Mutagenesis, Site-Directed, Phosphotransferases (Alcohol Group Acceptor), DNA Primers, Saccharomyces cerevisiae Proteins, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review