Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate

Saiardi, Adolfo; Nagata, Eiichiro; Luo, Hongbo R.; Sawa, Akira; Luo, Xiaojiang; Snowman, Adele M.; Snyder, Solomon H.

doi:10.1073/pnas.041614598

Cited by 110Protein Kinase Regulation and GTPase SignalingCalcium signaling and nucleotide metabolismPI3K/AKT/mTOR signaling in cancer

Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate

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Saiardi, Adolfo, Nagata, Eiichiro, Luo, Hongbo R., Sawa, Akira, Luo, Xiaojiang, Snowman, Adele M., Snyder, Solomon H.·2001·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.041614598PMC PMC30134

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Abstract

Using a consensus sequence in inositol phosphate kinase, we have identified and cloned a 44-kDa mammalian inositol phosphate kinase with broader catalytic capacities than any other member of the family and which we designate mammalian inositol phosphate multikinase (mIPMK). By phosphorylating inositol 4,5-bisphosphate, mIPMK provides an alternative biosynthesis for inositol 1,4,5-trisphosphate [Ins(1,4,5) P 3 ]. mIPMK also can form the pyrophosphate disphosphoinositol tetrakisphosphate (PP-Ins P 4 ) from Ins P 5 . Additionally, mIPMK forms Ins P 4 from Ins(1,4,5) P 3 and Ins P 5 from Ins(1,3,4,5) P 4 .

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IPMK, the mammalian homologue of Arg82, has been reported to phosphorylate Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P4 and then Ins(1,3,4,5,6)P5.
“IPMK, the mammalian homologue of Arg82, has been reported to phosphorylate Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P4 and then Ins(1,3,4,5,6)P540,41.”
From Structure of Hdac3 Bound to Co-Repressor and Inositol Tetraphosphate (2012) · cites this paper as [40]
The Results (page unavailable) show that mammalian IPMK converts Ins(1,4,5)P3 to Ins(1,3,4,5)P4 and then to Ins(1,3,4,5,6)P5. The cited sentence gives the intermediate as Ins(1,3,4,5,6)P4, which is not the intermediate reported in the paper. (LLM, conf=0.90)
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Authors: Saiardi, A., Nagata, E., Luo, H. R., Sawa, A., Luo, X., Snowman, A. M., & Snyder, S. H.
Affiliations: Johns Hopkins University (US)
Corresponding author: Snyder, Solomon H.
ORCID: Saiardi, Adolfo
Nagata, Eiichiro
Luo, Hongbo R.
Sawa, Akira
Snyder, Solomon H.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2001-02-13
Volume: 98
Issue: 5
Pages: 2306-2311
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.041614598
PMC: PMC30134
OpenAlex: W1997739014
Cited by: 110
References: 35
Citations by year: 2026: 3 · 2025: 2 · 2024: 2 · 2022: 4 · 2021: 1 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 4 · 2014: 3 · 2013: 5 · 2012: 3
FWCI: 2.56
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: U.S. Public Health Service (MH‐18501, DA-00074)
National Institute of Mental Health (R01MH018501, R37MH018501, MH-18501)
National Institute on Drug Abuse (DA 00074, K05DA000074)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords: inositol polyphosphate multikinase, inositol 1,4,5-trisphosphate, inositol pyrophosphates, inositol 1,3,4,5-tetrakisphosphate, enzyme cloning, mammalian enzymes
MeSH terms: Amino Acid Sequence, Animals, Base Sequence, Cloning, Molecular, Male, Molecular Sequence Data, Inositol 1,4,5-Trisphosphate, Rats, Sprague-Dawley, Sequence Homology, Amino Acid, In Situ Hybridization, Phosphotransferases (Alcohol Group Acceptor), DNA Primers, Rats

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Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate

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