The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Activation of PPARδ alters lipid metabolism in db/db mice
Open accessAbstract
Peroxisome proliferator‐activated receptors (PPARs) are nuclear receptors, which heterodimerize with the retinoid X receptor and bind to peroxisome proliferator response elements in the promoters of regulated genes. Despite the wealth of information available on the function of PPARα and PPARγ, relatively little is known about the most widely expressed PPAR subtype, PPARδ. Here we show that treatment of insulin resistant db/db mice with the PPARδ agonist L‐165 041, at doses that had no effect on either glucose or triglycerides, raised total plasma cholesterol concentrations. The increased cholesterol was primarily associated with high density lipoprotein (HDL) particles, as shown by fast protein liquid chromatography analysis. These data were corroborated by the chemical analysis of the lipoproteins isolated by ultracentrifugation, demonstrating that treatment with L‐165 041 produced an increase in circulating HDL without major changes in very low or low density lipoproteins. White adipose tissue lipoprotein lipase activity was reduced following treatment with the PPARδ ligand, but was increased by a PPARγ agonist. These data suggest both that PPARδ is involved in the regulation of cholesterol metabolism in db/db mice and that PPARδ ligands could potentially have therapeutic value.
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“Since PPAR␥ has been shown to increase LPL activity via a direct transcriptional effect on the LPL promoter (75),”
From Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance (2003) · cites this paper as [75]
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15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ
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Self-citationPPARδ Is an APC-Regulated Target of Nonsteroidal Anti-Inflammatory Drugs
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- 10.1210/en.137.10.4189 · DOI · Paper page
- 10.1210/me.6.10.1634 · DOI
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Cheng, P. T. W., Kick, E. K., & Mukherjee, R. (2021) · Wiley eBooks · doi:10.1002/0471266949.bmc191.pub2
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Downie, M. M. T., & Kealey, T. (2007) · Basic and clinical dermatology · doi:10.3109/9781420018417.005
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El‐Jamal, N. (2012) · theses.fr (ABES) · doi:10.70675/19534eecz98c4z48b2z92f6z0eb4d568fe93
BindingDB Entry 50017904: 3,4,5-Trisubstituted isoxazoles as novel PPARdelta agonists: Part 1.
BindingDB (2009) · UC San Diego · doi:10.7270/q2v987pc
BindingDB Entry 3155: 3,4,5-Trisubstituted isoxazoles as novel PPARdelta agonists. Part 2.
BindingDB (2009) · UC San Diego · doi:10.7270/q23x84z3
BindingDB Entry 50018018: Studies towards the conception of new selective PPARbeta/delta ligands.
BindingDB (2009) · UC San Diego · doi:10.7270/q28915hc
BindingDB Entry 50017618: 1,3,5-Trisubstituted aryls as highly selective PPARdelta agonists.
BindingDB (2009) · UC San Diego · doi:10.7270/q2xw4jdg
Efecte de l'activació de PPARβ/δ sobre l'oxidació d'àcids grassos i el procés inflamatori
Barroso, E. (2011) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Metadata
- Authors
- Leibowitz, M. D., Fiévet, C., Hennuyer, N., Peinado-Onsurbe, J., Duez, H., Berger, J., Cullinan, C. A., Sparrow, C. P., Baffic, J., Berger, G. D., Santini, C., Marquis, R. W., Tolman, R. L., Smith, R. G., Moller, D. E., & Auwerx, J.
- Affiliations
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- Inserm (FR)
- Corresponding author
- Leibowitz, Mark D.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2000-05-12
- Volume
- 473
- Issue
- 3
- Pages
- 333-336
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2024254257
- Cited by
- 308
- References
- 26
- Citations by year
- 2025: 2 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 9 · 2017: 4 · 2016: 6 · 2015: 9 · 2014: 7 · 2013: 13 · 2012: 8
- FWCI
- 7.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
- Keywords
- PPARδ, db/db mice, type 2 diabetes, insulin resistance, HDL cholesterol, serum cholesterol, lipoprotein lipase, white adipose tissue, PPARγ agonists, lipid metabolism, nuclear receptors
- MeSH terms
- Acetates, Adipose Tissue, Animals, Blood Glucose, Cholesterol, Chromatography, Liquid, DNA-Binding Proteins, Ligands, Lipids, Lipoprotein Lipase, Lipoproteins, Male, Mice, Inbred C57BL, Mice, Mutant Strains, Phenols, Phenoxyacetates, Transcription Factors, Triglycerides, Ultracentrifugation, Receptors, Cytoplasmic and Nuclear, Mice
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