The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Chaperone‐like activity of synucleins
Abstract
Synucleins are a family of small proteins that are predominantly expressed in neurons. The functions of the synucleins are not entirely understood, but they have been implicated in the pathogenesis of several neurodegenerative diseases. Our data show that α‐, β‐ or γ‐synuclein suppresses the aggregation of thermally denatured alcohol dehydrogenase and chemically denatured insulin. The A53T but not the A30P mutant α‐synuclein was able to inhibit the aggregation of insulin and the chaperone‐like activity of α‐synuclein was lost upon removal of its C‐terminal residues 98–140. These results demonstrate that synucleins with the exception of the A30P mutant possess chaperone‐like activity.
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Self-citationMutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease
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AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease
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Cited by
Initiation and Synergistic Fibrillization of Tau and Alpha-Synuclein
Giasson, B. I., Forman, M. S., Higuchi, M., Golbe, L. I., Graves, C. L., Kotzbauer, P. T., Trojanowski, J. Q., & Lee, V. M.-Y. (2003) · Science · doi:10.1126/science.1082324 · Cited by 879
Self-citationTFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity
Decressac, M., Mattsson, B., Weikop, P., Lundblad, M., Jakobsson, J., & Björklund, A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305623110 · Cited by 753
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A Role for α-Synuclein in the Regulation of Dopamine Biosynthesis
Perez, R. G., Waymire, J. C., Lin, E., Liu, J. J., Guo, F., & Zigmond, M. J. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03090.2002 · Cited by 598
El-Agnaf, O. M. A., Salem, S. A., Paleologou, K. E., Cooper, L. J., Fullwood, N. J., Gibson, M. J., Curran, M. D., Court, J. A., Mann, D. M. A., Ikeda, S.-I., et al. (2003) · The FASEB Journal · doi:10.1096/fj.03-0098fje · Cited by 590
Metadata
- Authors
- Souza, J. M., Giasson, B. I., Lee, V. M.-Y., & Ischiropoulos, H.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2000-05-23
- Volume
- 474
- Issue
- 1
- Pages
- 116-119
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2004315433
- Cited by
- 221
- References
- 5
- FWCI
- 10.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- Souza, J. M., Giasson, B. I., Lee, V. M.-Y., & Ischiropoulos, H. (2000). Chaperone‐like activity of synucleins. FEBS Letters. https://doi.org/10.1016/s0014-5793(00)01563-5
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
