Endogenous nitric oxide synthase inhibitors are responsible for the L‐arginine paradox

Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure

Leone, A., Moncada, S., Vallance, P., Calver, A., & Collier, J. (1992) · The Lancet · doi:10.1016/0140-6736(92)90865-z · Cited by 2,107

Asymmetric Dimethylarginine (ADMA): A Novel Risk Factor for Endothelial Dysfunction: Its Role in Hypercholesterolemia

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Nitric oxide synthase isozymes. Characterization, purification, molecular cloning, and functions.

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L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans.

Creager, M. A., Gallagher, S. J., Girerd, X. J., Coleman, S. M., Dzau, V. J., & Cooke, J. P. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115987 · Cited by 809

Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine

Drexler, H., Zeiher, A. M., Meinzer, K., & Just, H. (1991) · The Lancet · doi:10.1016/0140-6736(91)92372-9 · Cited by 794

Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst.

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Biochemical Evidence for Impaired Nitric Oxide Synthesis in Patients With Peripheral Arterial Occlusive Disease

Böger, R. H., Bode‐Böger, S. M., Thiele, W., Junker, W., Alexander, K., & Frölich, J. C. (1997) · Circulation · doi:10.1161/01.cir.95.8.2068 · Cited by 490

Reduced Urinary Excretion of Nitric Oxide Metabolites and Increased Plasma Levels of Asymmetric Dimethylarginine in Men with Essential Hypertension

Surdacki, A., Nowicki, M. P., Sandmann, J., Tsikas, D., Boeger, R. H., Bode-Boeger, S. M., Kruszelnicka-Kwiatkowska, O., Kokot, F., Dubiel, J. S., & Froelich, J. C. (1999) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199904000-00020 · Cited by 422

Isolation and Identification of N,N- and N,N' -Dimethylarginine, Nε-Mono-, Di-, and Trimethyllysine, and Glucosylgalactosyl- and Galactosyl-δ-hydroxylysine from Human Urine

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Interference ofL-Arginine Analogues withL-Arginine Transport Mediated by the y+Carrier hCAT-2B

Closs, E. I., Basha, F. Z., Habermeier, A., & Förstermann, U. (1997) · Nitric Oxide · doi:10.1006/niox.1996.0106 · Cited by 385

Asymmetric Dimethylarginine Plasma Concentrations Differ in Patients with End-Stage Renal Disease

Kielstein, J. T., Böger, R. H., BODE-BÖGER, S. M., SCHÄFFER, J., BARBEY, M., Koch, K. M., & Frölich, J. C. (1999) · Journal of the American Society of Nephrology · doi:10.1681/asn.v103594 · Cited by 360

Elevatedl-Arginine/Dimethylarginine Ratio Contributes to Enhanced Systemic NO Production by Dietaryl-Arginine in Hypercholesterolemic Rabbits

Bode‐Böger, S. M., Böger, R. H., Kienke, S., Junker, W., & Frölich, J. C. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.0279 · Cited by 303

L-arginine augments endothelium-dependent vasodilation in cholesterol-fed rabbits.

Girerd, X. J., Hirsch, A. T., Cooke, J. P., Dzau, V. J., & Creager, M. A. (1990) · Circulation Research · doi:10.1161/01.res.67.6.1301 · Cited by 267

Protein Methylation

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Restoring vascular nitric oxide formation by l-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease

Böger, R. H., Bode‐Böger, S. M., Thiele, W., Creutzig, A., Alexander, K., & Frölich, J. C. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00375-1 · Cited by 263

L‐arginine‐induced vasodilation in healthy humans:pharmacokinetic–pharmacodynamic relationship

Bode‐Böger, S. M., Böger, R. H., Galland, A., Tsikas, D., & Frölich, J. C. (1998) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.1998.00803.x · Cited by 258

Supplementation of hypercholesterolaemic rabbits with L-arginine reduces the vascular release of superoxide anions and restores NO production

Böger, R. H., Bode-Böger, S. M., Mügge, A., Kienke, S., Brandes, R., Dwenger, A., & Frölich, J. C. (1995) · Atherosclerosis · doi:10.1016/0021-9150(95)05582-h · Cited by 252

l -Arginine Induces Nitric Oxide–Dependent Vasodilation in Patients With Critical Limb Ischemia

Bode‐Böger, S. M., Böger, R. H., Alfke, H., Heinzel, D., Tsikas, D., Creutzig, A., Alexander, K., & Frölich, J. C. (1996) · Circulation · doi:10.1161/01.cir.93.1.85 · Cited by 196

N-Nitro-L-arginine and N-Monomethyl-L-arginine Exhibit a Different Pattern of Inactivation Toward the Three Nitric Oxide Synthases

Reif, D. W., & Mccreedy, S. A. (1995) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1995.1356 · Cited by 185

Endothelial cells metabolize NG -monomethyl-L-arginine to L-citrulline and subsequently to L-arginine

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The l-arginine—nitric oxide pathway: role in atherosclerosis and therapeutic implications

Böger, R. H., Bode‐Böger, S. M., & Frölich, J. C. (1996) · Atherosclerosis · doi:10.1016/s0021-9150(96)05953-9 · Cited by 168

L-arginine normalizes endothelial function in cerebral vessels from hypercholesterolemic rabbits.

Rossitch, E., Alexander, E., Black, P. M., & Cooke, J. P. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115132 · Cited by 161

Response of cerebral blood vessels to an endogenous inhibitor of nitric oxide synthase

Faraci, F. M., Brian, J. E., & Heistad, D. D. (1995) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1995.269.5.h1522 · Cited by 159

Inhibitors of brain nitric oxide synthase. Binding kinetics, metabolism, and enzyme inactivation.

Klatt, P., Schmidt, K., Brünner, F., & Mayer, B. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42080-1 · Cited by 158

l -Arginine Infusion Decreases Peripheral Arterial Resistance and Inhibits Platelet Aggregation in Healthy Subjects

Bode‐Böger, S. M., Böger, R. H., Creutzig, A., Tsikas, D., Gutzki, F. M., Alexander, K. G., & Frölich, J. C. (1994) · Clinical Science · doi:10.1042/cs0870303 · Cited by 148

Irreversible inactivation of macrophage and brain nitric oxide synthase by L-NG-methylarginine requires NADPH-dependent hydroxylation

Feldman, P. L., Griffith, O. W., Hong, H., & Stuehr, D. J. (1993) · Journal of Medicinal Chemistry · doi:10.1021/jm00056a009 · Cited by 127

l ‐ARGININE INFUSION INDUCES HYPOTENSION AND DIURESIS/NATRIURESIS WITH CONCOMITANT INCREASED URINARY EXCRETION OF NITRITE/NITRATE AND CYCLIC GMP IN HUMANS

Kanno, K., Hirata, Y., Emori, T., Ohta, K., Eguchi, S., Imai, T., & Marumo, F. (1992) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1992.tb00514.x · Cited by 125

Inactivation of macrophage nitric oxide synthase activity by NG-Methyl-L-arginine

Olken, N. M., Rusche, K. M., Richards, M. K., & Marletta, M. A. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)91864-9 · Cited by 105

Accelerated intimal hyperplasia and increased endogenous inhibitors for NO synthesis in rabbits with alloxan‐induced hyperglycaemia

Masuda, H., Goto, M., Tamaoki, S., & Azuma, H. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702298 · Cited by 99

Role of L-arginine-nitric oxide pathway in hypertension

Hishikawa, K., Nakaki, T., Suzuki, H., Katot, R., & Saruta, T. (1993) · Journal of Hypertension · doi:10.1097/00004872-199306000-00008 · Cited by 90

Assessment of nitric oxide synthase activity in vitro and in vivo by gas chromatography–mass spectrometry

Tsikas, D., Sandmann, J., Savva, A., Lueßen, P., Böger, R. H., Gutzki, F., Mayer, B., & Frölich, J. C. (2000) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(00)00142-0 · Cited by 85

Mechanistic probes of N-hydroxylation of L-arginine by the inducible nitric oxide synthase from murine macrophages

Pufahl, R. A., Nanjappan, P., Woodard, R. W., & Marletta, M. A. (1992) · Biochemistry · doi:10.1021/bi00144a024 · Cited by 79

Long term administration of L-arginine, L-NAME, and the exogenous NO donor molsidomine modulates urinary nitrate and cGMP excretion in rats

Böger, R. H., Bode‐Böger, S. M., Gerecke, U., & Frölich, J. C. (1994) · Cardiovascular Research · doi:10.1093/cvr/28.4.494 · Cited by 76

METHYLATED AMINO ACID RESIDUES OF PROTEINS OF BRAIN AND OTHER ORGANS

Kakimoto, Y., Matsuoka, Y., Miyake, M., & Konishi, H. (1975) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1975.tb03653.x · Cited by 58

URINARY NO3− EXCRETION AS AN INDICATOR OF NITRIC OXIDE FORMATION IN VIVO DURING ORAL ADMINISTRATION OF l ‐ARGININE OR l ‐NAME IN RATS

Böger, R. H., Bode‐Böger, S. M., Gerecke, U., Gutzki, F. M., Tsikas, D., & Frölich, J. C. (1996) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1996.tb03055.x · Cited by 57

L-arginine Stimulates NO-Dependent Vasodilation in Healthy Humans—Effect of Somatostatin Pretreatment

Bode‐Böger, S. M., Böger, R. H., Löffler, M., Tsikas, D., Brabant, G. E., & Frölich, J. C. (1999) · Journal of Investigative Medicine · doi:10.1177/108155899904700107 · Cited by 43

Isolation and Identification of Methylarginines from Bovine Brain

Kotani, K., Ueno, S., Sano, A., & Kakimoto, Y. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09371.x · Cited by 28

Correspondence

(1998) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(97)00482-9 · Cited by 16

Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation

Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541

The emerging role of asymmetric dimethylarginine as a novel cardiovascular risk factor

Böger, R. H. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(03)00500-5 · Cited by 393

Marked Increase of Asymmetric Dimethylarginine in Patients with Incipient Primary Chronic Renal Disease

Kielstein, J. T., Diaeresisger, R. H. B., Bode‐Böger, S. M., Diaeresis]lich, J. D. C. F., Haller, H. G., Ritz, E., & Fliser, D. (2002) · Journal of the American Society of Nephrology · doi:10.1681/asn.v131170 · Cited by 368

Asymmetric Dimethylarginine, an Endogenous Inhibitor of Nitric Oxide Synthase, Explains the “L-Arginine Paradox” and Acts as a Novel Cardiovascular Risk Factor

Böger, R. H. (2004) · The Journal of Nutrition · doi:10.1093/jn/134.10.2842s · Cited by 363

Translational control of inducible nitric oxide synthase expression by arginine can explain the arginine paradox

Lee, J.-H., Ryu, H., Ferrante, R. J., Morris, S. M., & Ratan, R. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0735876100 · Cited by 365

The arginine paradox.

Nakaki, T., & Hishikawa, K. (2002) · Folia Pharmacologica Japonica · doi:10.1254/fpj.119.7 · Cited by 15

Biological significance of endogenous methylarginines that inhibit nitric oxide synthases

Leiper, J. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00162-5 · Cited by 458

Effects of Arginase I and II on the local production of NO

Elms, S. C., Morris, S. M., Caldwell, W., & Fulton, D. (2009) · The FASEB Journal · doi:10.1096/fasebj.23.1_supplement.628.5

Inhibition of nitric oxide synthase by l -arginine metabolites

Das, I., & Khan, N. (1995) · Biochemical Society Transactions · doi:10.1042/bst023324s · Cited by 4

To Give or Not to Give? Lessons from the Arginine Paradox

Dioguardi, F. S. (2011) · Lifestyle Genomics · doi:10.1159/000327777 · Cited by 95