The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Endogenous nitric oxide synthase inhibitors are responsible for the L‐arginine paradox
Abstract
L‐Arginine, the substrate of nitric oxide (NO) synthases (NOSs), is found in the mammalian organism at concentrations by far exceeding K M values of these enzymes. Therefore, additional L‐arginine should not enhance NO formation. In vivo, however, increasing L‐arginine concentration in plasma has been shown repeatedly to increase NO production. This phenomenon has been named the L‐arginine paradox; it has found no satisfactory explanation so far. In the present work, evidence for the hypothesis that the endogenous NOS inhibitors methylarginines, asymmetric dimethylarginine being the most powerful (IC 50 1.5 μM), are responsible for the L‐arginine paradox is presented.
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“Pyruvate dehydrogenase (887), α-ketoglutarate dehydrogenase (130, 887, 952), and monoamine oxygenase A and B (290) have all been demonstrated to serve as ROS sources.”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [952]
Citations
Cites
Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure
Leone, A., Moncada, S., Vallance, P., Calver, A., & Collier, J. (1992) · The Lancet · doi:10.1016/0140-6736(92)90865-z · Cited by 2,107
Böger, R. H., Bode-Böger, S. M., Szuba, A., Tsao, P. S., Chan, J. R., Tangphao, O., Blaschke, T. F., & Cooke, J. P. (1998) · Circulation · doi:10.1161/01.cir.98.18.1842 · Cited by 1,181
Self-citationNitric oxide synthase isozymes. Characterization, purification, molecular cloning, and functions.
Förstermann, U., Closs, E. I., Pollock, J. S., Nakane, M., Schwarz, P., Gath, I., & Kleinert, H. (1994) · Hypertension · doi:10.1161/01.hyp.23.6.1121 · Cited by 1,122
L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans.
Creager, M. A., Gallagher, S. J., Girerd, X. J., Coleman, S. M., Dzau, V. J., & Cooke, J. P. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115987 · Cited by 809
Drexler, H., Zeiher, A. M., Meinzer, K., & Just, H. (1991) · The Lancet · doi:10.1016/0140-6736(91)92372-9 · Cited by 794
Iyengar, R., Stuehr, D. J., & Marletta, M. A. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.18.6369 · Cited by 664
Böger, R. H., Bode‐Böger, S. M., Thiele, W., Junker, W., Alexander, K., & Frölich, J. C. (1997) · Circulation · doi:10.1161/01.cir.95.8.2068 · Cited by 490
Self-citationSurdacki, A., Nowicki, M. P., Sandmann, J., Tsikas, D., Boeger, R. H., Bode-Boeger, S. M., Kruszelnicka-Kwiatkowska, O., Kokot, F., Dubiel, J. S., & Froelich, J. C. (1999) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199904000-00020 · Cited by 422
Self-citationKakimoto, Y., & Akazawa, S. (1970) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62716-4 · Cited by 409
Interference ofL-Arginine Analogues withL-Arginine Transport Mediated by the y+Carrier hCAT-2B
Closs, E. I., Basha, F. Z., Habermeier, A., & Förstermann, U. (1997) · Nitric Oxide · doi:10.1006/niox.1996.0106 · Cited by 385
Research works printed but not linked: 3
- Bode-Böger S.M., 1999, J. Invest. Med., 47, 43
- Sandmann J. (2000) Ph.D. thesis University of Hannover Hannover.
- Böger R.H., 2000, Naunyn-Schmiedeberg's Arch. Pharmacol., 361, R42
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Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation
Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541
The emerging role of asymmetric dimethylarginine as a novel cardiovascular risk factor
Böger, R. H. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(03)00500-5 · Cited by 393
Self-citationKielstein, J. T., Diaeresisger, R. H. B., Bode‐Böger, S. M., Diaeresis]lich, J. D. C. F., Haller, H. G., Ritz, E., & Fliser, D. (2002) · Journal of the American Society of Nephrology · doi:10.1681/asn.v131170 · Cited by 368
Self-citationBöger, R. H. (2004) · The Journal of Nutrition · doi:10.1093/jn/134.10.2842s · Cited by 363
Self-citationLee, J.-H., Ryu, H., Ferrante, R. J., Morris, S. M., & Ratan, R. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0735876100 · Cited by 365
Metadata
- Authors
- Tsikas, D., Böger, R. H., Sandmann, J., Bode-Böger, S. M., & Frölich, J. C.
- Affiliations
- Medizinische Hochschule Hannover (DE)
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2000-07-24
- Volume
- 478
- Issue
- 1-2
- Pages
- 1-3
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2000940740
- Cited by
- 237
- References
- 38
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 6 · 2020: 6 · 2019: 9 · 2018: 4 · 2017: 11 · 2016: 3 · 2015: 16 · 2014: 6 · 2013: 10 · 2012: 11
- FWCI
- 7.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- nitric oxide synthase inhibitors, asymmetric dimethylarginine, methylarginines, nitric oxide production, L-arginine
- MeSH terms
- Animals, Arginine, Binding, Competitive, Enzyme Inhibitors, Humans, Kinetics, Models, Biological, Thermodynamics, Meta-Analysis as Topic, Nitric Oxide Synthase, omega-N-Methylarginine, Inhibitory Concentration 50, Rats
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