The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species: Structure–activity relationship of cloned LPA receptors
Open accessAbstract
We examined the structure–activity relationship of cloned lysophosphatidic acid (LPA) receptors (endothelial cell differentiation gene (EDG) 2, EDG4, and EDG7) by measuring [Ca 2+]i in Sf9 insect cells expressing each receptor using LPA with various acyl chains bound at either the sn‐1 or the sn‐2 position of the glycerol backbone. For EDG7 the highest reactivity was observed with LPA with Δ9‐unsaturated fatty acid (oleic (18:1), linoleic (18:2), and linolenic (18:3)) at sn‐2 followed by 2‐palmitoleoyl (16:1) and 2‐arachidonoyl (20:4) LPA. In contrast, EDG2 and EDG4 showed broad ligand specificities, although EDG2 and EDG4 discriminated between 14:0 (myristoyl) and 16:0 (palmitoyl), and 12:0 (lauroyl) and 14:0 LPAs, respectively. EDG7 recognizes the cis double bond at the Δ9 position of octadecanoyl residues, since 2‐elaidoyl (18:1, trans) and 2‐petroselinoyl (18:1, cis‐Δ12) LPA were poor ligands for EDG7. In conclusion, the present study demonstrates that each LPA receptor can be activated differentially by the LPA species.
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Hecht, J. H., Weiner, J. A., Post, S. R., & Chun, J. (1996) · The Journal of cell biology · doi:10.1083/jcb.135.4.1071 · Cited by 720
Lysophosphatidic Acid, a Multifunctional Phospholipid Messenger
Moolenaar, W. H. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.12949 · Cited by 584
Fourcade, O., Simon, M.-F., Viodé, C., Rugani, N., Leballe, F., Ragab, A., Fournié, B., Sarda, L., & Chap, H. (1995) · Cell · doi:10.1016/0092-8674(95)90295-3 · Cited by 536
Characterization of a Novel Subtype of Human G Protein-coupled Receptor for Lysophosphatidic Acid
An, S., Bleu, T., Hallmark, O. G., & Goetzl, E. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.14.7906 · Cited by 528
Bandoh, K., Aoki, J., Hosono, H., Kobayashi, S., Kobayashi, T., Murakami-Murofushi, K., Tsujimoto, M., Arai, H., & Inoue, K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.39.27776 · Cited by 511
Self-citationLysophosphatidic acid: G-protein signalling and cellular responses
Moolenaar, W. H., Kranenburg, O., Postma, F. R., & Zondag, G. C. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80059-2 · Cited by 486
Tigyi, G., & Miledi, R. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36618-9 · Cited by 346
Characterization of an ovarian cancer activating factor in ascites from ovarian cancer patients.
Xu, Y., Gaudette, D. C., Boynton, J., Frankel, A., Fang, X. J., Sharma, A., Hurteau, J. A., Casey, G., Goodbody, A., & Mellors, A. (1995) · PubMed · Cited by 322
van Corven, E. J., van Rijswijk, A., Jalink, K., van der Bend, R. L., BLITTERSWIJK, W. J. V., & Moolenaar, W. H. (1992) · Biochemical Journal · doi:10.1042/bj2810163 · Cited by 262
Lysophosphatidic acids induce proliferation of cultured vascular smooth muscle cells from rat aorta
Tokumura, A., Iimori, M., Nishioka, Y., Kitahara, M., Sakashita, M., & Tanaka, S. (1994) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1994.267.1.c204 · Cited by 192
Cited by
The multifaceted roles of fatty acid synthesis in cancer
Röhrig, F., & Schulze, A. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.89 · Cited by 1,651
Lysophospholipid Receptors: Signaling and Biology
Ishii, I., Fukushima, N., Ye, X., & Chun, J. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073731 · Cited by 771
Noguchi, K., Ishii, S., & Shimizu, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302648200 · Cited by 557
Boucharaba, A., Serre, C.-M., Grès, S., Saulnier-Blache, J. S., Bordet, J.-C., Guglielmi, J., Clézardin, P., & Peyruchaud, O. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422123 · Cited by 462
Two pathways for lysophosphatidic acid production
AOKI, J. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2008.06.005 · Cited by 448
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Metadata
- Authors
- Bandoh, K., Aoki, J., Taira, A., Tsujimoto, M., Arai, H., & Inoue, K.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2000-07-24
- Volume
- 478
- Issue
- 1-2
- Pages
- 159-165
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2057633574
- Cited by
- 261
- References
- 22
- FWCI
- 4.84
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bandoh, K., Aoki, J., Taira, A., Tsujimoto, M., Arai, H., & Inoue, K. (2000). Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species: Structure–activity relationship of cloned LPA receptors. FEBS Letters. https://doi.org/10.1016/s0014-5793(00)01827-5
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