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The Antennapedia peptide penetratin translocates across lipid bilayers – the first direct observation
Open accessAbstract
The potential use of polypeptides and oligonucleotides for therapeutical purposes has been questioned because of their inherently poor cellular uptake. However, the 16‐mer oligopeptide penetratin, derived from the homeodomain of Antennapedia, has been reported to enter cells readily via a non‐endocytotic and receptor‐ and transporter‐independent pathway, even when conjugated to large hydrophilic molecules. We here present the first study where penetratin is shown to traverse a pure lipid bilayer. The results support the idea that the uptake mechanism involves only the interaction of the peptide with the membrane lipids. Furthermore, we conclude that the translocation does not involve pore formation.
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Cited by
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Hervé, F., Ghinea, N., & Scherrmann, J.-M. (2008) · The AAPS Journal · doi:10.1208/s12248-008-9055-2 · Cited by 676
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BROOKS, H., LEBLEU, B., & VIVES, E. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.12.001 · Cited by 667
Nickel, W. (2003) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2003.03577.x · Cited by 586
Studies on the Internalization Mechanism of Cationic Cell-penetrating Peptides
Drin, G., Cottin, S., Blanc, E., Rees, A. R., & Temsamani, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303938200 · Cited by 530
Arginine‐rich cell‐penetrating peptides
Schmidt, N., Mishra, A., Lai, G. H., & Wong, G. C. L. (2010) · FEBS Letters · doi:10.1016/j.febslet.2009.11.046 · Cited by 521
Metadata
- Authors
- Thorén, P. E. G., Persson, D., Karlsson, M., & Nordén, B.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2000-10-05
- Volume
- 482
- Issue
- 3
- Pages
- 265-268
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2171846923
- Cited by
- 241
- References
- 0
- FWCI
- 4.39
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Thorén, P. E. G., Persson, D., Karlsson, M., & Nordén, B. (2000). The Antennapedia peptide penetratin translocates across lipid bilayers – the first direct observation. FEBS Letters. https://doi.org/10.1016/s0014-5793(00)02072-x
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