The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Kidney produces a novel acylated peptide, ghrelin
Abstract
Ghrelin is a novel growth hormone‐releasing peptide with a unique acylated structure. Here we reveal that prepro‐ghrelin gene is expressed in the mouse kidney and glomerulus. We also show by reverse‐phase high performance liquid chromatography coupled with radioimmunoassay that the mouse kidney does produce ghrelin. The ghrelin immunoreactivity in the mouse kidney is 6.79±0.48 fmol/mg (n=5), which is much more abundant than that in the mouse plasma of 0.339±0.029 fmol/μl (n=6). Furthermore, prepro‐ghrelin gene is expressed in cultured rat mesangial cells, fibroblast‐like NRK‐49F cells and mouse podocytes, but not in rat epithelial cell‐like NRK‐52E cells. Ghrelin receptor gene is also expressed in the rat kidney. These findings demonstrate that the kidney, glomerulus and renal cells express prepro‐ghrelin gene and ghrelin is produced locally in the kidney, and suggest the endocrine and/or paracrine roles of ghrelin in the kidney.
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Cites
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K. (1999) · Nature · doi:10.1038/45230 · Cited by 8,479
Self-citationA Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release
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Regulation of insulin-like growth factor I gene expression by growth hormone.
Mathews, L. S., Norstedt, G., & Palmiter, R. D. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.24.9343 · Cited by 553
Hosoda, H., Kojima, M., Matsuo, H., & Kangawa, K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002784200 · Cited by 362
Self-citationMolecular Analysis of Rat Pituitary and Hypothalamic Growth Hormone Secretagogue Receptors
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Growth Hormone, the Insulin-Like Growth Factor System, and the Kidney*
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Cited by
Ghrelin: Structure and Function
Kojima, M., & Kangawa, K. (2005) · Physiological Reviews · doi:10.1152/physrev.00012.2004 · Cited by 2,810
Self-citationCowley, M. A., Smith, R. G., Diano, S., Tschöp, M., Pronchuk, N., Grove, K. L., Strasburger, C. J., Bidlingmaier, M., Esterman, M., Heiman, M. L., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00063-1 · Cited by 1,679
Biological, Physiological, Pathophysiological, and Pharmacological Aspects of Ghrelin
van der Lely, A. J., Tschöp, M., Heiman, M. L., & Ghigo, E. (2004) · Endocrine Reviews · doi:10.1210/er.2002-0029 · Cited by 1,187
Minireview: Ghrelin and the Regulation of Energy Balance--A Hypothalamic Perspective
Horváth, T. L., Diano, S., Sótonyi, P., Heiman, M. L., & Tschöp, M. H. (2001) · Endocrinology · doi:10.1210/en.142.10.4163 · Cited by 567
The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas
Wierup, N., Svensson, H., Mulder, H., & Sundler, F. (2002) · Regulatory Peptides · doi:10.1016/s0167-0115(02)00067-8 · Cited by 457
Metadata
- Authors
- Mori, K., Yoshimoto, A., Takaya, K., Hosoda, K., Ariyasu, H., Yahata, K., Mukoyama, M., Sugawara, A., Hosoda, H., Kojima, M., Kangawa, K., & Nakao, K.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2000-12-12
- Volume
- 486
- Issue
- 3
- Pages
- 213-216
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2016173062
- Cited by
- 332
- References
- 18
- FWCI
- 7.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mori, K., Yoshimoto, A., Takaya, K., Hosoda, K., Ariyasu, H., Yahata, K., Mukoyama, M., Sugawara, A., Hosoda, H., Kojima, M., Kangawa, K., & Nakao, K. (2000). Kidney produces a novel acylated peptide, ghrelin. FEBS Letters. https://doi.org/10.1016/s0014-5793(00)02308-5
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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