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Hepatic maturation in differentiating embryonic stem cells in vitro
Abstract
We investigated the potential of mouse embryonic stem (ES) cells to differentiate into hepatocytes in vitro. Differentiating ES cells expressed endodermal‐specific genes, such as α‐fetoprotein, transthyretin, α 1‐anti‐trypsin and albumin, when cultured without additional growth factors and late differential markers of hepatic development, such as tyrosine aminotransferase (TAT) and glucose‐6‐phosphatase (G6P), when cultured in the presence of growth factors critical for late embryonic liver development. Further, induction of TAT and G6P expression was induced regardless of expression of the functional SEK1 gene, which is thought to provide a survival signal for hepatocytes during an early stage of liver morphogenesis. The data indicate that the in vitro ES differentiation system has a potential to generate mature hepatocytes. The system has also been found useful in analyzing the role of growth factors and intracellular signaling molecules in hepatic development.
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Cited by
In vitro Hepatic Differentiation of Human Mesenchymal Stem Cells
Lee, K., Kuo, T. K., Whang–Peng, J., Chung, Y., Lin, C., Chou, S., Chen, J., Chen, Y., & Lee, O. K. (2004) · Hepatology · doi:10.1002/hep.20469 · Cited by 865
An extracellular matrix microarray for probing cellular differentiation
Flaim, C. J., Chien, S., & Bhatia, S. N. (2005) · Nature Methods · doi:10.1038/nmeth736 · Cited by 803
Embryonic Stem Cells: Prospects for Developmental Biology and Cell Therapy
Wobus, A. M., & Boheler, K. R. (2005) · Physiological Reviews · doi:10.1152/physrev.00054.2003 · Cited by 782
Tissue Engineering and Regenerative Medicine: History, Progress, and Challenges
Berthiaume, F., Maguire, T. J., & Yarmush, M. L. (2011) · Annual Review of Chemical and Biomolecular Engineering · doi:10.1146/annurev-chembioeng-061010-114257 · Cited by 734
Nestin expression ? a property of multi-lineage progenitor cells?
Wiese, C., Rolletschek, A., Kania, G., Blyszczuk, P., Tarasov, K. V., Tarasova, Y., Wersto, R. P., Boheler, K. R., & Wobus, A. M. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4144-6 · Cited by 620
Metadata
- Authors
- Hamazaki, T., Iiboshi, Y., Oka, M., Papst, P. J., Meacham, A. M., Zon, L. I., & Terada, N.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2001-05-18
- Volume
- 497
- Issue
- 1
- Pages
- 15-19
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2009359841
- Cited by
- 432
- References
- 0
- FWCI
- 9.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hamazaki, T., Iiboshi, Y., Oka, M., Papst, P. J., Meacham, A. M., Zon, L. I., & Terada, N. (2001). Hepatic maturation in differentiating embryonic stem cells in vitro. FEBS Letters. https://doi.org/10.1016/s0014-5793(01)02423-1
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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