Tissue Engineering and Regenerative Medicine: History, Progress, and Challenges
Abstract
The past three decades have seen the emergence of an endeavor called tissue engineering and regenerative medicine in which scientists, engineers, and physicians apply tools from a variety of fields to construct biological substitutes that can mimic tissues for diagnostic and research purposes and can replace (or help regenerate) diseased and injured tissues. A significant portion of this effort has been translated to actual therapies, especially in the areas of skin replacement and, to a lesser extent, cartilage repair. A good amount of thoughtful work has also yielded prototypes of other tissue substitutes such as nerve conduits, blood vessels, liver, and even heart. Forward movement to clinical product, however, has been slow. Another offshoot of these efforts has been the incorporation of some new exciting technologies (e.g., microfabrication, 3D printing) that may enable future breakthroughs. In this review we highlight the modest beginnings of the field and then describe three application examples that are in various stages of development, ranging from relatively mature (skin) to ongoing proof-of-concept (cartilage) to early stage (liver). We then discuss some of the major issues that limit the development of complex tissues, some of which are fundamentals-based, whereas others stem from the needs of the end users.
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Collagen- or fibrin-based products are the most established ECMs used clinically to guide regeneration of skin, heart valves, trachea, muscle, and tendon.
“Collagen- or fibrin-based products are the most established ECMs being used clinically to guide regeneration of different tissues, including skin, heart valves, trachea, muscle, and tendon (71, 139).”
From Wound repair and regeneration: Mechanisms, signaling, and translation (2014) · cites this paper as [71]
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Wound repair and regeneration: Mechanisms, signaling, and translation
Eming, S. A., Martin, P., & Tomic-Canic, M. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009337 · Cited by 3,562 · see citing works
Fiber-based tissue engineering: progress, challenges, and opportunities
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Biomimetic 3D tissue models for advanced high-throughput drug screening
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Ultrasound-assisted tissue engineering
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Advances in guided bone regeneration membranes: a comprehensive review of materials and techniques
Ali, M., Mohd Noor, S. N. F., Mohamad, H., Ullah, F., Javed, F., & Abdul Hamid, Z. A. (2024) · Biomedical Physics & Engineering Express · doi:10.1088/2057-1976/ad1e75 · Cited by 19 · see citing works
- Authors
- Berthiaume, F., Maguire, T. J., & Yarmush, M. L.
- Affiliations
- Department of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854;
- Rutgers, The State University of New Jersey (US)
- Venue
- Annual Review of Chemical and Biomolecular Engineering
- Publisher
- Annual Reviews
- Published
- 2011-07-15
- Volume
- 2
- Issue
- 1
- Pages
- 403-430
- ISSN
- 1947-5438 (ISSN-L)
- 1947-5446
- OpenAlex
- W2136638400
- Cited by
- 734
- References
- 167
- Citations by year
- 2026: 46 · 2025: 58 · 2024: 72 · 2023: 78 · 2022: 84 · 2021: 54 · 2020: 69 · 2019: 39 · 2018: 37 · 2017: 43 · 2016: 45 · 2015: 28 · 2014: 35 · 2013: 28 · 2012: 13
- FWCI
- 4.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Chemical and Biomolecular Engineering (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Keywords
- tissue engineering, regenerative medicine, tissue substitutes, skin substitutes, cartilage repair, nerve conduits, vascular tissue engineering, liver tissue engineering, cardiac tissue engineering, microfabrication, 3D printing, clinical translation, history of tissue engineering
- MeSH terms
- Animals, Biocompatible Materials, Cartilage, History of Medicine, Humans, Liver, Skin, Tissue Engineering, Regenerative Medicine, History, 18th Century, History, 19th Century, History, 20th Century, History, 21st Century, History, Ancient
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