The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
WW and SH3 domains, two different scaffolds to recognize proline‐rich ligands
Abstract
WW domains are small protein modules composed of approximately 40 amino acids. These domains fold as a stable, triple stranded β‐sheet and recognize proline‐containing ligands. WW domains are found in many different signaling and structural proteins, often localized in the cytoplasm as well as in the cell nucleus. Based on analyses of seven structures of WW domains, we discuss their diverse binding preferences and sequence conservation patterns. While modeling WW domains for which structures have not been determined we uncovered a case of potential molecular and functional convergence between WW and SH3 domains. The binding surface of the modeled WW domain of Npw38 protein shows a remarkable similarity to the SH3 domain of Sem5 protein, confirming biochemical data on similar binding predilections of both domains.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Modular binding domains in signal transduction proteins
Cohen, G. B., Ren, R., & Baltimore, D. (1995) · Cell · doi:10.1016/0092-8674(95)90406-9 · Cited by 951
The WW domain: a signalling site in dystrophin?
Bork, P., & Sudol, M. (1994) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(94)90053-1 · Cited by 388
Self-citation
Cited by
Virus budding and the ESCRT pathway
Votteler, J., & Sundquist, W. I. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.08.012 · Cited by 547
High-resolution mapping of protein sequence-function relationships
Fowler, D. M., Araya, C. L., Fleishman, S. J., Kellogg, E. H., Stephany, J. J., Baker, D., & Fields, S. (2010) · Nature Methods · doi:10.1038/nmeth.1492 · Cited by 516
Vitamin A and retinoid signaling: genomic and nongenomic effects
Al Tanoury, Z., Piskunov, A., & Rochette-Egly, C. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r030833 · Cited by 408
Retinoic acid receptors: From molecular mechanisms to cancer therapy
di Masi, A., Leboffe, L., De Marinis, E., Pagano, F., Cicconi, L., Rochette-Egly, C., Lo-Coco, F., Ascenzi, P., & Nervi, C. (2015) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2014.12.003 · Cited by 403
The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation
Weissman, A. M., Shabek, N., & Ciechanover, A. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3173 · Cited by 317
Metadata
- Authors
- Macias, M. J., Wiesner, S., & Sudol, M.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2001-12-20
- Volume
- 513
- Issue
- 1
- Pages
- 30-37
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2043186621
- Cited by
- 478
- References
- 2
- FWCI
- 7.17
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: WW and SH3 domains, two different scaffolds to recognize proline‐rich ligands. https://app.cochat.ai/papers/10.1016/s0014-5793(01)03290-2
- The paper
- Macias, M. J., Wiesner, S., & Sudol, M. (2002). WW and SH3 domains, two different scaffolds to recognize proline‐rich ligands. FEBS Letters. https://doi.org/10.1016/s0014-5793(01)03290-2
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
